Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters
SHORT COMMUNICATION
Received:
Accepted:
- 178 Downloads
- 16 Citations
Abstract
This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder.Two-dimensional (2D) gel electrophoresis revealed that suicide attempters differed from non-attempters in one protein with an approximate molecular weight of 33 kD and an isoelectric point of 5.2. Proteomic analysis of the CSF is a promising non hypothesis-driven screening method for the detection of new candidate genes in neurobiological suicide research.
Key words
major depressive disorder suicide attempt proteomic analysis cerebrospinal fluidPreview
Unable to display preview. Download preview PDF.
References
- 1.Brunner J, Bronisch T (1999) Neurobiological correlates of suicidal behaviour. Fortschr Neurol Psychiat 67:391–412PubMedCrossRefGoogle Scholar
- 2.Hanash S (2003) Disease proteomics. Nature 422:226–232PubMedCrossRefGoogle Scholar
- 3.Koller G, Preuß UW, Bottlender M, Wenzel K, Soyka M (2002) Impulsivity and aggression as predictors of suicide attempts in alcoholics. Eur Arch Psychiatry Clin Neurosci 252:155–160PubMedGoogle Scholar
- 4.Mann JJ (1998) The neurobiology of suicide. Nature Medicine 4:25–30PubMedCrossRefGoogle Scholar
- 5.Roggenbach J, Müller-Oerlinghausen B, Franke L (2002) Suicidality, impulsivity and aggression—is there a link to 5HIAA concentration in the cerebrospinal fluid? Psychiatry Res 113:193–206PubMedCrossRefGoogle Scholar
- 6.Stefulj J, Büttner A, Kubat M, Zill P, Balija M, Eisenmenger W, Bondy B, Jernej B (2004) 5HT-2C receptor polymorphism in suicide victims. Association studies in German and Slavic populations. Eur Arch Psychiatry Clin Neurosci 254:224–227PubMedGoogle Scholar
- 7.Turecki G (2001) Suicidal behavior: is there a genetic predisposition? Bipolar Disord 3:335–349PubMedCrossRefGoogle Scholar
- 8.Zobel AW, Nickel T, Sonntag A, Uhr M, Holsboer F, Ising M (2001) Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression: a prospective study. J Psychiatr Res 35:83–94PubMedCrossRefGoogle Scholar
Copyright information
© Steinkopff-Verlag 2005