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European Archives of Oto-Rhino-Laryngology

, Volume 257, Issue 5, pp 260–262 | Cite as

Malignant fibrous histiocytoma of the larynx after radiotherapy for squamous cell carcinoma

  • L. Resta
  • A. Pennella
  • M. G. Fiore
  • M. A. Botticella
Laryngology

Abstract

A few cases of malignant fibrous histiocytoma (MFH) of the larynx have been reported to date. All ages may be affected, but the tumor is more prevalent in the sixth and seventh decade of life. We describe a case of MFH in a 71-year-old Italian man who 8 years before underwent a right cordectomy and radiotherapy for squamous cell carcinoma. Recurrent tumor was found to be MFH. The clinico-pathological features of this tumor are presented and the possible relationship between radiotherapy and MFH discussed. The neoplasm was characterized by spindle-shaped atypical cells arranged in a diffuse storiform pattern. Mitoses were prominent, numerous, and often atypical. Immunohistochemically, neoplastic cells were strongly positive for vimentin and α1-antichymotrypsin but were negative for cytokeratins and S-100 protein. These findings confirmed the diagnosis and excluded possible sarcomatoid carcinoma, inflammatory pseudotumor, and a new carcinosarcoma. The risk of sarcoma after radiotherapy for squamous cell carcinoma in the larynx is very low when considering the frequent use of radiotherapy, but long follow-ups are required.

Key words Laryngeal neoplasms Malignant ¶histiocytoma Radiotherapy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • L. Resta
    • 1
  • A. Pennella
    • 1
  • M. G. Fiore
    • 1
  • M. A. Botticella
    • 1
  1. 1.Istituto di Anatomia e Istologia Patologica, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy e-mail: lresta@anatopat.uniba.itIT

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