European Archives of Oto-Rhino-Laryngology

, Volume 256, Issue 10, pp 514–519

Expression of intermediate filament proteins in benign lesions of the oral mucosa

  • L.-A. van der Velden
  • J. J. Manni
  • F. C. S. Ramaekers
  • W. Kuijpers
Basic science

Abstract

Immunohistochemistry with monospecific antibodies was used to study the expression patterns of cytokeratins (Cks) and vimentin in non-dysplastic lesions of the oral cavity, including lichen planus and fibromas. In hyperplastic lesions, Ck expression did not deviate significantly from the normal non-keratinizing squamous epithelium of the oral cavity. Hyperkeratotic lesions showed pronounced aberrations in their Ck profile. These lesions were characterized by extended expression of the keratinization marker Ck 10, the basal cell Ck 14 and the hyperproliferation-associated Ck 16 in the suprabasal compartment. The stratification markers Cks 4 and 13 showed a decreased expression. Coexpression of Cks and vimentin was found in lesions having accumulations of inflammatory cells in the subepithelial cell layer. These changes are felt to characterize benign mucosal lesions without dysplasia and might be helpful for distinguishing these lesions from potentially malignant ones.

Key words Cytokeratin Vimentin Mucosa Benign oral cavity Lesions 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • L.-A. van der Velden
    • 1
  • J. J. Manni
    • 2
  • F. C. S. Ramaekers
    • 3
  • W. Kuijpers
    • 4
  1. 1.Department of Otorhinolaryngology, Erasmus University Medical Centre Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsNL
  2. 2.Department of Otorhinolaryngology, University Hospital Maastricht, Maastricht, The NetherlandsNL
  3. 3.Department of Molecular Cell Biology and Genetics, University of Maastricht, Maastricht, The NetherlandsNL
  4. 4.Department of Otorhinolaryngology, University Hospital Nijmegen, Nijmegen, The NetherlandsNL

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