Risk factors for recurrence of laryngeal amyloidosis treated by microforceps and CO2 laser

  • Xiufa Wu
  • Jing Zhang
  • Chunsheng WeiEmail author



Laryngeal amyloidosis is a benign, slowly progressive disease. The factors affecting the recurrence of LA have not been studied before for the rarity and incomplete understanding of this disease. To investigate the risk factors for the laryngeal amyloidosis treated by microforceps or carbon dioxide laser under microlaryngoscope, a retrospective review was conducted.

Materials and methods

One hundred and four patients (42 male and 72 female, with an average age of 51.3 years) with laryngeal amyloidosis were identified. The cases were collected from January 1989 to May 2014 at the Eye, Ear, Nose, and Throat Hospital of Fudan University.


Seventy-five patients complained of hoarseness, 36 patients complained of hoarseness and dyspnea, and 3 patients complained of foreign body sensation. All patients underwent surgical removal of the amyloid deposits (via microforceps, CO2 laser and tracheotomy). Thirty patients developed recurrences requiring further treatments. The duration from onset to the treatment and age affected the recurrence of laryngeal amyloidosis, the surgery method, stenotic degree and stenotic area of subglottic area and trachea did not affect the recurrence of the disease.


Early diagnosis and treatment of laryngeal amyloidosis may reduce the recurrence of the disease. Regular follow-up is necessary to find any recurrence.


Laryngeal amyloidosis Recurrence Hoarseness Treatment Selection and timing of operation Duration from onset to the treatment 



This study was supported by Science and Technology Commission of Shanghai Municipality.


Science and Technology Commission of Shanghai Municipality (CN) (Grant number: 18411965600).

Compliance with ethical standards

Conflict of interest

None of the authors has potential conflicts of interest. None of the authors has or has had any affiliation with any organization with a financial interest, direct or indirect, in the subject matter or materials discussed in the manuscript that may affect the conduct of reporting of the work submitted.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otolaryngology-Head and Neck SurgeryEye, Ear, Nose, and Throat Hospital of Fudan UniversityShanghaiPeople’s Republic of China
  2. 2.Department of Facial Plastic and Reconstructive SurgeryEye, Ear, Nose, and Throat Hospital of Fudan UniversityShanghaiPeople’s Republic of China

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