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European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 12, pp 3519–3519 | Cite as

Regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility

  • Sora YasriEmail author
  • Viroj Wiwanitkit
Letter to the Editor
  • 150 Downloads

Dear, we read the publication on “Association of regenerating gene (*REG) 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma (NPC) susceptibility in southern Chinese population” with a great interest and would like to share some ideas on this report. Xing et al. noted that “the REG1A 2922C/T polymorphism is associated with an increased risk of developing NPC” [1]. Indeed, any genetic polymorphism results in molecular change that can further affect the biological process and phenotype expression. The presented finding by Xing et al. shows the clinical interrelation for only one variant, the 2022 C/T. The interesting question is whether there is any effect of other genetic polymorphisms that are not studied in the present report. The examples of other genetic polymorphisms that relate to risk of developing NPC are COX-2 gene polymorphism [2] and 5′-UTR Polymorphism of MYC [3]. For a final conclusion, there should be further assessment on other possible effects from other confounding genetic factors.

Notes

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

References

  1. 1.
    Xing H, Chen X, Sun H, Han Y, Ding L, Chen X (2019) Association of regenerating gene 1A single-nucleotide polymorphisms and nasopharyngeal carcinoma susceptibility in southern Chinese population. Eur Arch Otorhinolaryngol.  https://doi.org/10.1007/s00405-019-05645-9(Epub ahead of print) CrossRefPubMedGoogle Scholar
  2. 2.
    Sun N, Wang XQ (2019) Correlation between COX-2 gene polymorphism and susceptibility to nasopharyngeal carcinoma. Eur Rev Med Pharmacol Sci 23(13):5770–5778PubMedGoogle Scholar
  3. 3.
    Guo Z, Wang Y, Zhao Y, Jin Y, An L, Xu H, Liu Z, Chen X, Zhou H, Wang H, Zhang W (2019) A Functional 5'-UTR polymorphism of MYC contributes to nasopharyngeal carcinoma susceptibility and chemoradiotherapy induced toxicities. J Cancer 10(1):147–155CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.KMT Primary Care CenterBangkokThailand
  2. 2.Dr. DY Patil UniversityPuneIndia

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