European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 12, pp 3461–3466 | Cite as

Clinical characteristics of acinic cell carcinoma and secretory carcinoma of the parotid gland

  • Tetsuya TeradaEmail author
  • Ryo Kawata
  • Keiki Noro
  • Masaaki Higashino
  • Shuji Nishikawa
  • Shin-ichi Haginomori
  • Yoshitaka Kurisu
  • Hiroko Kuwabara
  • Yoshinobu Hirose
Head and Neck



Mammary analogue secretory carcinoma (SC) of the parotid gland is a relatively uncommon cancer associated with the ETV6–NTRK3 fusion product similar to breast cancer. The clinical characteristics and outcome of treatment were reviewed for patients with this tumor at our hospital.


In this retrospective case series, 24 patients with a diagnosis of acinic cell carcinoma (AcCC) of the parotid gland were classified as having either SC or AcCC based on analysis of the ETV6–NTRK3 fusion gene. These two groups were compared with respect to their clinical and imaging characteristics (MRI/US), cytologic findings, accuracy of fine-needle aspiration cytology and frozen section, treatment outcomes, and immunohistochemical findings.


Based on re-classification by ETV6–NTRK3 fusion gene analysis, the diagnosis was SC in 14 patients and AcCC in 10 patients. The SC group had a significantly higher proportion of male patients and was also significantly younger than the AcCC group. Imaging studies revealed that SC was significantly more likely to show internal heterogeneity. Correct grading of both tumors was comparable by fine needle aspiration, with the rate being 60% for AcCC and 50% for SC. Diagnosis by frozen section biopsy diagnosis obtained the correct grade in 90% of the AcCC group and 93% of the SC group.


In 24 patients previously diagnosed with AcCC, re-analysis of the ETV6–NTRK3 fusion product indicated that 14 patients actually had SC. Although AcCC and SC show similarities of their biological aggressiveness and prognosis, patients with SC were significantly more likely to be male and younger.


Parotid carcinoma Acinic cell carcinoma Secretory carcinoma ETV6 



The authors have no funding, financial relationships, or conflicts of interest to disclose.

Compliance with ethical standards

Conflict of interest

The authors have no funding, financial relationships, or conflicts of interest to disclose.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology-Head and Neck SurgeryOsaka Medical CollegeTakatsukiJapan
  2. 2.Department of PathologyOsaka Medical CollegeTakatsukiJapan

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