Therapeutic effect of vitamin D supplementation on allergic rhinitis
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In this study, we aimed to determine whether short-term (2 months) vitamin D supplementation could improve the allergic symptoms in AR patients.
A randomized double-blind placebo-controlled clinical trial was performed on allergic rhinitis patients with vitamin D deficiency from Nov. 2017–2018. 80 cases with allergic rhinitis and vitamin D deficiency were divided into two groups and vitamin D plus routine antihistamine medication (cetirizine) was prescribed for the study group, whereas the control group received cetirizine plus placebo. The clinical symptoms questionnaire was completed at baseline and after 4 and 8 weeks of treatment initiation. Vitamin D levels were re-measured at the end of the 8-week treatment course.
In total, 80 patients with allergic rhinitis and vitamin D deficiency were enrolled. Among them, 35 cases and 33 controls visited the clinic after 8 weeks; the mean age in the aforementioned groups was 29.68 years and 29.13 years demonstrating no meaningful difference (P > 0.05). At study initiation, the mean vitamin D level was 14 ng/ml and 14.67 ng/ml in the study and control groups, respectively, indicating no significant difference (P = 0.189). The mean serum vitamin D level at 8 weeks of treatment in the study group (24.08 ng/ml) indicated a statistically meaningful difference with the mean vitamin D level at baseline (P < 0.001). Comparison of the mean scores of symptoms severity showed no significant difference between the two groups at study initiation and 4 weeks later (P = 0.073), whereas a significant difference was obtained between baseline and 8 weeks of treatment initiation (P = 0.007).
Based on the findings of the present study, it can be concluded that vitamin D supplementation along with antihistamines can result in relative symptoms improvement in AR patients with vitamin D deficiency.
KeywordsVitamin D Allergic rhinitis Serum level of vitamin D
This project was supported by a grant from the Research Deputy of Mashhad University of Medical Sciences, Mashhad, Iran, with approval code of 30659.
Compliance with ethical standards
Conflict of interest
None of the authors have a conflict of interest to declare.
- 4.Kulthanan K, Chusakul S, Recto MT, Gabriel M, Aw DC, Prepageran N, Wong A, Leong JL, Foong H, Quang VT, Zuberbier T (2018) Economic burden of the inadequate management of allergic rhinitis and urticaria in asian countries based on the GA2LEN model. Allergy Asthma Immunol Res 10(4):370–378CrossRefPubMedPubMedCentralGoogle Scholar
- 5.Bunyavanich S, Rifas-Shiman SL, Platts-Mills TA, Workman L, Sordillo JE, Camargo CA Jr, Gillman MW, Gold DR, Litonjua AA (2016) Prenatal, perinatal, and childhood vitamin D exposure and their association with childhood allergic rhinitis and allergic sensitization. J Allergy Clin Immunol 137(4):1063–1070CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O’connor GT, Sandel M, Iverson RE, Lee-Paritz A, Strunk RC, Bacharier LB (2016) Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial. JAMA 315(4):362–370CrossRefPubMedGoogle Scholar