European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 7, pp 2015–2022 | Cite as

Two-handed tying technique in vocal fold mucosa microsuture for the treatment of Reinke’s edema

  • Faya Liang
  • Renhui Chen
  • Peiliang Lin
  • Pin Han
  • Qian Cai
  • Xiaoming HuangEmail author



Removal of Reinke’s edema may result in moderate to large-sized mucosal defect on the vocal fold, which heals by secondary intention. Microsuturing this defect may lead to primary wound healing with fastened recovery and less scar, but costs extra time and effort. Exploring methods that can shorten microsuture time is helpful for the wider application of this technology.

Study design



57 patients with Reinke’s edema, who were admitted from November 2010 to June 2018, were enrolled as research subjects for the retrospective analysis. 27 patients were the knot pusher group (from November 2010 to March 2015), and 30 patients were the two-handed tying group (from April 2015 to June 2018). Evaluation indicators include the number of knots, the average time for suturing and tying the knot for each patient, and the occurrence of complications, subjective and objective voice assessments.


All patients underwent successful operation. The average time for making knots in the knot pusher group and two-handed tying group was 668.40 ± 173.73 s and 328.73 ± 121.0 s, respectively, and there was a statistically significant difference between the two groups (p < 0.001). No significant difference was noted in the mucosal avulsion, overall incidence of complications between the groups, and no significant difference was found between the two groups in terms of the preoperative and 3-month postoperative subjective and objective indicators.


Microsuturing of Reinke’s edema microflaps using the two-handed tying technique can achieve the similar effect with the knot pusher method, and save operation time while the surgeon is well trained.

Level of evidence



Microsuture Reinke’s edema Tying technique 



This study was supported by Natural Science Foundation of Guangdong Province, China (2018A030313691).

Compliance with ethical standards

Conflict of interest

The authors declared that they have no conflicts of interest to this work.

Supplementary material

405_2019_5480_MOESM1_ESM.pdf (138 kb)
Supplementary file1 (PDF 137 kb)
405_2019_5480_MOESM2_ESM.pdf (12.9 mb)
Supplementary file2 (PDF 13200 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019
corrected publication 2019

Authors and Affiliations

  1. 1.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationSun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangzhouChina
  2. 2.Department of Otorhinolaryngology-Head & Neck SurgerySun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangzhouChina
  3. 3.Institute of Hearing and Speech-Language ScienceSun Yat-Sen UniversityGuangzhouChina

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