Oral cancer of Sigmund Freud
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We read with great interest the theory of Trimarchi et al.  about the possible cocain-induced disease of Sigmund Freud. The authors disregard the fact that the oral disease of Sigmund Freud was a repeatedly histologically proven squamous cell carcinoma of the oral cavity in a heavy smoker patient.
The protracted course and long survival from his incompletely resected oral cancer correspond to a highly differentiated variant of squamous cell carcinoma with slow-growing invasive pattern of a verrucous carcinoma we published in this journal before .
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The authors declare that they have no conflict of interest.
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This article does not contain any studies with human participants or animals performed by any of the authors.