Perimarginal lymph nodes: an undervalued entity in oral cancer
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In a previous study, we gave a surgical description of a group of lymph nodes in the submandibular area at risk of remaining undissected during neck dissection (ND) for which we have proposed the term “perimarginal nodes” (PMNs) due to their proximity to marginal mandibular nerve (MMN). The aim of this study is to evaluate prevalence of PMNs involvement in oral cavity squamous cell cancer (OCSCC) and to verify if metastases are related to primary tumor characteristics or to the state of the neck.
We recruited a total of 39 consecutive patients diagnosed with OCSCC candidate to ND. Histological characteristics of PMNs were analyzed and the incidence of metastases in relation to the primary tumor characteristics were noted.
PMNs were found to be involved with metastases in 8 patients (20.5%). No characteristic of the primary tumor seems to influence the metastatic involvement of the PMNs.
PMNs represent a frequent site of micro-metastases in patients diagnosed with OCSCC regardless of other characteristics of the primary tumor.
KeywordsPerimarginal nodes Perifacial nodes Submandibular nodes Neck dissection Oral cavity cancer
Compliance with ethical standards
Conflict of interest
The authors declare that there is no conflict of interest and this research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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