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Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency

  • Fatih Alper AkcanEmail author
  • Yusuf Dündar
  • Hümeyra Bayram Akcan
  • Ahmet Uluat
  • Derya Cebeci
  • İlhan Ünlü
Rhinology
  • 36 Downloads

Abstract

Objectives

The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.

Methods

A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.

Results

The mean 25(HO)Vitamin-D levels were 14.32 ± 4.23 ng/mL (7–24.6) and 29.38 ± 7.05 ng/mL (25–53.8) in study and control groups, respectively (p < 0.001). The mean NMC time was 11.15 ± 3.05 (6.3–17.6) and 8.40 ± 2.33 (6–13.2) in study and control groups, respectively (p < 0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 ± 10.03 and the mean NMC time was 9.56 ± 2.54 (p < 0.001).

Conclusion

The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.

Keywords

Vitamin-D Nasal mucociliary clearance Upper respiratory tract infection Ear infection 

Notes

Acknowledgements

All authors would like to thank Dr. Uche Nwagu for her English revisions.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that there is no conflict of interest regarding publication of this paper.

Ethical approval

This article contains studies with human participants and local ethics committee approval was obtained before the study.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of OtorhinolaryngologyDüzce University School of MedicineDüzceTurkey
  2. 2.Department of Otolaryngology–Head and Neck SurgeryWayne State UniversityDetroitUSA
  3. 3.Department of Internal Medicine, Ministry of HealthAtatürk HospitalDüzceTurkey
  4. 4.Department of Otolaryngology, Ministry of HealthBalıkesir HospitalBalıkesirTurkey

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