Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency
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The main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.
A total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.
The mean 25(HO)Vitamin-D levels were 14.32 ± 4.23 ng/mL (7–24.6) and 29.38 ± 7.05 ng/mL (25–53.8) in study and control groups, respectively (p < 0.001). The mean NMC time was 11.15 ± 3.05 (6.3–17.6) and 8.40 ± 2.33 (6–13.2) in study and control groups, respectively (p < 0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 ± 10.03 and the mean NMC time was 9.56 ± 2.54 (p < 0.001).
The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.
KeywordsVitamin-D Nasal mucociliary clearance Upper respiratory tract infection Ear infection
All authors would like to thank Dr. Uche Nwagu for her English revisions.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Compliance with ethical standards
Conflict of interest
The authors declare that there is no conflict of interest regarding publication of this paper.
This article contains studies with human participants and local ethics committee approval was obtained before the study.
Informed consent was obtained from all individual participants included in the study.
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