Advertisement

European Archives of Oto-Rhino-Laryngology

, Volume 276, Issue 1, pp 139–142 | Cite as

Olfactory function and olfactory bulb volume in Wilson’s disease

  • Nazan DegirmenciEmail author
  • Bayram Veyseller
  • Hasmet Hanagasi
  • Basar Bilgic
  • Defne Gurbuz
  • Ali Toprak
  • Orhan Ozturan
Rhinology
  • 65 Downloads

Abstract

Purpose

To evaluate the olfactory function and the olfactory bulb (OB) volume changes in Wilson’s Disease (WD) patients.

Methods

A prospective, controlled, single-blinded study was planned. 12 patients with WD (Group 1) and 12 healthy subjects (Group 2) were included in the study. Connecticut Chemosensory Clinical Research Center (CCCRC) test was applied to evaluate olfactory functions. OB volumes were measured with a 1.5 T General Electric Signa Excite MRI scanner.

Results

There was a significant difference between the CCCRC scores of the two groups (p < 0.05). The difference of the OB volumes of the two groups was insignificant (p > 0.05).

Conclusions

WD patients are likely to experience olfactory dysfunction, so its assessment may be a useful tool to the follow-up care of these patients, although further studies are needed to evaluate correlations in WD evolution.

Keywords

Wilson’s disease Olfactory dysfunction Olfactory bulb Olfaction 

Notes

Funding

This research received no specific grant from any funding agency, commercial or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional guidelines on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Salari M, Fayyazi E, Mirmosayyeb O (2018) Magnetic resonance imaging findings in diagnosis and prognosis of Wilson disease. J Res Med Sci 23:23.  https://doi.org/10.4103/jrms.JRMS_362_16 CrossRefGoogle Scholar
  2. 2.
    Mueller A, Reuner U, Landis B, Kitzler H, Reichmann H, Hummel T (2006) Extrapyramidal symptoms in Wilson’s disease are associated with olfactory dysfunction. Mov Disord 21(9):1311–1316.  https://doi.org/10.1002/mds.20989 CrossRefGoogle Scholar
  3. 3.
    Passali GC, Bove F, Vargiu L, Bentivoglio AR, Anzivino R, De Corso E, Galli J, Rigante M, Pandolfini M, Sergi B, Giuliani M, Cianfrone F, Paludetti G, Fasano A (2017) New olfactometric findings in Parkinson’s disease. Clin Otolaryngol 42(4):837–843.  https://doi.org/10.1111/coa.12816 CrossRefGoogle Scholar
  4. 4.
    Cain WS, Gent JF, Goodspeed RB, Leonard G (1988) Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 98(1):83–88.  https://doi.org/10.1288/00005537-198801000-00017 CrossRefGoogle Scholar
  5. 5.
    Veyseller B, Ozucer B, Karaaltin AB, Yildirim Y, Degirmenci N, Aksoy F, Ozturan O (2014) Connecticut (CCCRC) olfactory test: normative values in 426 healthy volunteers. Indian J Otolaryngol Head Neck Surg 66(1):31–34.  https://doi.org/10.1007/s12070-013-0632-z CrossRefGoogle Scholar
  6. 6.
    Veyseller B, Ozucer B, Degirmenci N, Gurbuz D, Tambas M, Altun M, Aksoy F, Ozturan O (2014) Olfactory bulb volume and olfactory function after radiotherapy in patients with nasopharyngeal cancer. Auris Nasus Larynx 41 (5):436–440.  https://doi.org/10.1016/j.anl.2014.02.004 CrossRefGoogle Scholar
  7. 7.
    Veyseller B, Ozucer B, Aksoy F, Yildirim YS, Gurbuz D, Balikci HH, Ozturan O (2012) Reduced olfactory bulb volume and diminished olfactory function in total laryngectomy patients: a prospective longitudinal study. Am J Rhinol Allergy 26(3):191–193.  https://doi.org/10.2500/ajra.2012.26.3768 CrossRefGoogle Scholar
  8. 8.
    Hummel T, Haehner A, Hummel C, Croy I, Iannilli E (2013) Lateralized differences in olfactory bulb volume relate to lateralized differences in olfactory function. Neuroscience 237:51–55.  https://doi.org/10.1016/j.neuroscience.2013.01.044 CrossRefGoogle Scholar
  9. 9.
    Wilson RS, Arnold SE, Schneider JA, Tang Y, Bennett DA (2007) The relationship between cerebral Alzheimer’s disease pathology and odour identification in old age. J Neurol Neurosurg Psychiatry 78(1):30–35.  https://doi.org/10.1136/jnnp.2006.099721 CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology and Head and Neck SurgeryBezmialem Vakif UniversityIstanbulTurkey
  2. 2.Department of Otorhinolaryngology and Head and Neck Surgery, Medical FacultyAcibadem UniversityIstanbulTurkey
  3. 3.Department of Neurology, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  4. 4.Department of RadiologyOkmeydani Training and Research HospitalIstanbulTurkey
  5. 5.Department of Biostatistics and Medical InformaticsBezmialem Vakif UniversityIstanbulTurkey

Personalised recommendations