Clinical utility of dynamic-enhanced MRI in salivary gland tumors: retrospective study and literature review

  • Takenori Ogawa
  • Ikuho Kojima
  • Ryo Ishii
  • Maya Sakamoto
  • Takaki Murata
  • Takahiro Suzuki
  • Kengo Kato
  • Ayako Nakanome
  • Akira Ohkoshi
  • Eiichi Ishida
  • Seiji Kakehata
  • Kiyoto Shiga
  • Yukio Katori
Head and Neck
  • 31 Downloads

Abstract

Purpose

To improve the diagnoses of the salivary gland tumors, a dynamic-enhanced MRI (dMRI) was investigated.

Methods

We conducted a retrospective chart review of 93 cases of salivary gland tumors. The histological diagnoses were obtained from all patients using a surgical specimen and/or an open biopsy specimen. The dMRI as well as fine-needle aspiration cytology (FNAC) and intraoperative frozen section (IFS) were analyzed. This study focused on the time-intensity curve (TIC) after injection, peak time (Tpeak), washout ratio (WR) as well as the gradient of enhancement and washout profile.

Results

The histological diagnoses included pleomorphic adenoma (PMA) in 53 cases, the Warthin tumors (WT) in 14 cases and malignant tumors (MT) in 26 cases. Incorrect diagnosis rate of FNAC and IFS were 5.2 and 8.3%, respectively. The TIC revealed differences among the three types of tumors. Tpeak as well as WR also revealed significant differences (p < 0.001). Tpeak were lower in order of WT, MT, PMA, respectively. WR of TICs at 30, 45 and 105 s after Tpeak were higher in order of WT, MT, PMA, respectively (p < 0.001). The gradient of increment and washout in the TIC curve was also an important parameter to distinguish the three types of tumors. In MT, the rapid enhancement pattern was found in high or intermediate histological grade tumors, whereas the slow enhancement pattern was exhibited in low grade tumors.

Conclusions

Our findings indicate that using Tpeak and WR, it is possible to distinguish between WT, PMA and MT. Additionally, a rapid enhancement pattern may be a potential marker for these tumors.

Keywords

MRI Dynamic-enhanced MRI Salivary gland tumor Diagnosis Fine-needle aspiration cytology 

Notes

Acknowledgements

We are grateful to Miles Kuperus for editorial work in the preparation of this manuscript.

Compliance with ethical standards

Conflict of interest

We declare no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study. The Institutional Review Board has approved this study [Approved no. 2016-1-754 (Tohoku University Graduate School of Medicine)].

Supplementary material

405_2018_4965_MOESM1_ESM.pptx (120 kb)
Supplementary material 1 Supplementary fig. 1: The box and whisker plot of TICs. a: 15 sec, b: 45 sec, c: 75 sec, d:105 sec. Maximum number, 25% percentile, median, 75% percentile and minimum number were shown in box and whisker plot. *: p&#x003C;0.01, * *: p&#x003C;0.05. Supplementary fig. 2: WR of TICs. a: 30 sec, b: 45 sec, c: 105 sec after Tpeak. *: p&#x003C;0.001 (PPTX 119 KB)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Takenori Ogawa
    • 1
  • Ikuho Kojima
    • 2
  • Ryo Ishii
    • 1
  • Maya Sakamoto
    • 2
  • Takaki Murata
    • 3
  • Takahiro Suzuki
    • 4
  • Kengo Kato
    • 1
  • Ayako Nakanome
    • 1
  • Akira Ohkoshi
    • 1
  • Eiichi Ishida
    • 1
  • Seiji Kakehata
    • 5
  • Kiyoto Shiga
    • 6
  • Yukio Katori
    • 1
  1. 1.Department of Otolaryngology-Head and Neck SurgeryTohoku University HospitalSendaiJapan
  2. 2.Department of Oral DiagnosisTohoku University HospitalSendaiJapan
  3. 3.Department of Diagnostic RadiologyTohoku University HospitalSendaiJapan
  4. 4.Department of OtorhinolaryngologyTohoku Medical and Pharmaceutical UniversitySendaiJapan
  5. 5.Department of Otolaryngology, Head and Neck SurgeryYamagata University School of MedicineYamagataJapan
  6. 6.Department of Head and Neck SurgeryIwate Medical UniversityMoriokaJapan

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