European Archives of Oto-Rhino-Laryngology

, Volume 275, Issue 6, pp 1513–1524 | Cite as

Gender differences in the presentation of dysphonia related to laryngopharyngeal reflux disease: a case-control study

  • Jérôme R. LechienEmail author
  • Kathy Huet
  • Mohamad Khalife
  • Anne-Françoise Fourneau
  • Camille Finck
  • Véronique Delvaux
  • Myriam Piccaluga
  • Bernard Harmegnies
  • Sven Saussez



To investigate the voice quality impairments in patients with laryngopharyngeal reflux (LPR) according to the gender.


Controlled multi-center study.

Materials and methods

80 LPR patients (40 males and 40 females) with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were included and clinically compared according to gender. To be considered as LPR patients, subjects responded to an empiric therapeutic trial based on pantoprazole intake and diet recommendations for 3 months or had positive pH/Impedance metry. Voice Handicap Index (VHI); Short Form Healthy Survey 36 (SF36), blinded Grade, Roughness, Breathiness, Asthenia, Strain and Instability (GRBASI); aerodynamic and acoustic measurements were assessed in all patients and compared with 80 healthy controls (40 males and 40 females) according to gender.


The most common reasons for the consultation were, respectively, globus sensation in males (22.5%) and dysphonia (27.5%) in female who complained more of breathing difficulties and choking episodes related to LPR than males (p = 0.024). From a quality of life standpoint, female had increased significant impact of LPR disease on vitality and mental health than male. Compared to healthy subjects, both LPR male and female patients had stronger values of G, R, B, S, I, VHI, percent jitter, percent shimmer, and soft palate index than controls. In addition, LPR female had stronger values of lowest fundamental frequency and all aerodynamic measurements than controls.


As showed in many other laryngeal conditions, voice quality of female could be more impaired by LPR than male. Some anatomical, histological and functional factors can be suspected and need additional future researches.


Laryngopharyngeal Reflux Laryngitis Voice 



American Journal Expert for the proofreading of the manuscript. This research has been subsidized by the ARC No. AUWB-2012-12/17-UMONS convention from Communauté Française de Belgique.


This research has been subsidized by the ARC No. AUWB-2012-12/17-UMONS convention from Communauté Française de Belgique.

Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jérôme R. Lechien
    • 1
    • 2
    • 3
    • 4
    Email author
  • Kathy Huet
    • 2
  • Mohamad Khalife
    • 3
  • Anne-Françoise Fourneau
    • 3
  • Camille Finck
    • 5
  • Véronique Delvaux
    • 2
  • Myriam Piccaluga
    • 2
  • Bernard Harmegnies
    • 2
  • Sven Saussez
    • 1
    • 3
    • 4
  1. 1.Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and TechnologyUniversity of Mons (UMons)MonsBelgium
  2. 2.Laboratory of Phonetics, Faculty of Psychology, Research Institute for Language sciences and TechnologyUniversity of Mons (UMons)MonsBelgium
  3. 3.Department of Otorhinolaryngology and Head and Neck Surgery, EpiCURA HospitalUMONS-EpiCURA Research plateformBaudourBelgium
  4. 4.Department of Otorhinolaryngology and Head and Neck SurgeryCHU de Bruxelles, CHU Saint-PierreBruxellesBelgium
  5. 5.Department of Otorhinolaryngology and Head and Neck SurgeryCHU de LiègeLiegeBelgium

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