European Archives of Oto-Rhino-Laryngology

, Volume 274, Issue 10, pp 3803–3810 | Cite as

Pattern of care and impact of prognostic factors in the outcome of ameloblastic carcinoma: a systematic review and individual patient data analysis of 199 cases

  • Prashanth Giridhar
  • Supriya MallickEmail author
  • Ashish Datt Upadhyay
  • Goura K. Rath


Ameloblastic carcinoma is a rare locally aggressive odontogenic neoplasm. These tumors are most commonly found to arise from mandible. Because of rarity, there is limited information about the clinical behaviour of such patients. We intended to perform this review of published literature to assess the demographic profile, pattern of care and assess survival outcomes. Two authors independently searched PubMed, Google search, and Cochrane library for eligible studies from 1950 until July 1 2016 published in English language. Data of 199 patients were retrieved from 94 publications for statistical analysis. Median age of the entire cohort was 49 years (range 7–91 years). The analysis revealed that a clear twofold higher incidence in male with male-to-female ratio was 2.4:1 (140:57). Mandible was found to be the commonest tumor location in 66.7% (n = 132) cases followed by maxilla (31.8%) (n = 64). The present analysis revealed that median PFS of 57 months (95% CI 39–120 months) with 5- and 10-year PFS was found to be 47.88 and 29.48%, respectively. Median OS for the entire cohort which was 122 months (95% CI 96–153 months) with 2- and 5-year OS for the entire cohort was 87.16 and 69.08%, respectively. In univariate analysis, patients with an R0 resection were found to have a favourable survival. In addition, patients with localized disease and younger age were found to have a better survival. Adjuvant radiation did not confer any survival advantage. The present analysis revealed excellent outcome for patients treated with an R0 resection. Older patients with high-risk factor may benefit from adjuvant radiation. Role of chemotherapy needs to be evaluated.


Ameloblastic carcinoma Surgery Pattern of care Radiotherapy Adjuvant 


Compliance with ethical standards

Financial support

No financial support received.

Conflict of interest

The authors have no conflict of interest

Supplementary material

405_2017_4631_MOESM1_ESM.docx (63 kb)
Supplementary material 1 (DOCX 62 kb)


  1. 1.
    Shafer WG, Hine MK, Levy BM (eds) (1983) A textbook of oral pathology, 4th edn. WB Saunders Co., Philadelphia, pp 280–281Google Scholar
  2. 2.
    Small IA, Waldron CA (1955) Ameloblastoma of the jaws. Oral Surg Oral Med Oral Pathol 8(3):281–297CrossRefPubMedGoogle Scholar
  3. 3.
    Avon SL, McComb J, Clokie C (2003) Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc 69(9):573–576PubMedGoogle Scholar
  4. 4.
    Reichart PA, Philipsen HP, Sonner S (1995) Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 31(2):86–99CrossRefGoogle Scholar
  5. 5.
    Kramer IR, Pindborg JJ, Shear M (1992) The WHO histological typing of odontogenic tumours: a commentary on the second edition. Cancer 70(12):2988–2994CrossRefPubMedGoogle Scholar
  6. 6.
    Corio RL, Goldblatt LI, Edwards PA, Hartman KS (1987) Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases. Oral Surg Oral Med Oral Pathol 64(5):570–576CrossRefPubMedGoogle Scholar
  7. 7.
    Atkinson CH, Harwood AR, Cummings BJ (1984) Ameloblastoma of the jaw: a reappraisal of the role of megavoltage irradiation. Cancer 53(4):869–873CrossRefPubMedGoogle Scholar
  8. 8.
    Datta R, Winston JS, Diaz-Reyes G, Loree TR, Myers L, Kuriakose MA et al (2003) Ameloblastic carcinoma: report of an aggressive case with multiple bony metastases. Am J Otolaryngol 24(1):64–69CrossRefPubMedGoogle Scholar
  9. 9.
    Ingram EA, Evans ML, Zitsch RP III (1996) Fine-needle aspiration cytology of ameloblastic carcinoma of the maxilla: a rare tumor. Diagn Cytopathol 14(3):249–252CrossRefPubMedGoogle Scholar
  10. 10.
    Gardner DG (1988) Radiotherapy in the treatment of ameloblastoma. Int J Oral Maxillofac Surg 17(3):201–205CrossRefPubMedGoogle Scholar
  11. 11.
    Kruse AL, Zwahlen RA, Grätz KW (2009) New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol 1(1):31–32CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Jensen AD, Ecker S, Ellerbrock M, Nikoghosyan A, Debus J, Münter MW (2011) Carbon ion therapy for ameloblastic carcinoma. Radiat Oncol 6:13CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Ramadas K, Jose CC, Subhashini J, Chandi SM, Viswanathan FR (1990) Pulmonary metastasis from ameloblastoma of the mandible treated with cisplatin, adriamycin and cyclophosphamide. Cancer 66(7):1475–1479CrossRefPubMedGoogle Scholar
  14. 14.
    Laughlin EH (1989) Metastasizing ameloblastoma. Cancer 64(3):776–780CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Radiation OncologyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of BiostatisticsAll India Institute of Medical SciencesNew DelhiIndia

Personalised recommendations