Ameloblastic carcinoma is a rare locally aggressive odontogenic neoplasm. These tumors are most commonly found to arise from mandible. Because of rarity, there is limited information about the clinical behaviour of such patients. We intended to perform this review of published literature to assess the demographic profile, pattern of care and assess survival outcomes. Two authors independently searched PubMed, Google search, and Cochrane library for eligible studies from 1950 until July 1 2016 published in English language. Data of 199 patients were retrieved from 94 publications for statistical analysis. Median age of the entire cohort was 49 years (range 7–91 years). The analysis revealed that a clear twofold higher incidence in male with male-to-female ratio was 2.4:1 (140:57). Mandible was found to be the commonest tumor location in 66.7% (n = 132) cases followed by maxilla (31.8%) (n = 64). The present analysis revealed that median PFS of 57 months (95% CI 39–120 months) with 5- and 10-year PFS was found to be 47.88 and 29.48%, respectively. Median OS for the entire cohort which was 122 months (95% CI 96–153 months) with 2- and 5-year OS for the entire cohort was 87.16 and 69.08%, respectively. In univariate analysis, patients with an R0 resection were found to have a favourable survival. In addition, patients with localized disease and younger age were found to have a better survival. Adjuvant radiation did not confer any survival advantage. The present analysis revealed excellent outcome for patients treated with an R0 resection. Older patients with high-risk factor may benefit from adjuvant radiation. Role of chemotherapy needs to be evaluated.
Ameloblastic carcinoma Surgery Pattern of care Radiotherapy Adjuvant
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Avon SL, McComb J, Clokie C (2003) Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc 69(9):573–576PubMedGoogle Scholar
Reichart PA, Philipsen HP, Sonner S (1995) Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 31(2):86–99CrossRefGoogle Scholar
Kramer IR, Pindborg JJ, Shear M (1992) The WHO histological typing of odontogenic tumours: a commentary on the second edition. Cancer 70(12):2988–2994CrossRefPubMedGoogle Scholar
Corio RL, Goldblatt LI, Edwards PA, Hartman KS (1987) Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases. Oral Surg Oral Med Oral Pathol 64(5):570–576CrossRefPubMedGoogle Scholar
Atkinson CH, Harwood AR, Cummings BJ (1984) Ameloblastoma of the jaw: a reappraisal of the role of megavoltage irradiation. Cancer 53(4):869–873CrossRefPubMedGoogle Scholar
Datta R, Winston JS, Diaz-Reyes G, Loree TR, Myers L, Kuriakose MA et al (2003) Ameloblastic carcinoma: report of an aggressive case with multiple bony metastases. Am J Otolaryngol 24(1):64–69CrossRefPubMedGoogle Scholar
Ingram EA, Evans ML, Zitsch RP III (1996) Fine-needle aspiration cytology of ameloblastic carcinoma of the maxilla: a rare tumor. Diagn Cytopathol 14(3):249–252CrossRefPubMedGoogle Scholar
Kruse AL, Zwahlen RA, Grätz KW (2009) New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol 1(1):31–32CrossRefPubMedPubMedCentralGoogle Scholar
Ramadas K, Jose CC, Subhashini J, Chandi SM, Viswanathan FR (1990) Pulmonary metastasis from ameloblastoma of the mandible treated with cisplatin, adriamycin and cyclophosphamide. Cancer 66(7):1475–1479CrossRefPubMedGoogle Scholar