Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands
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This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Higher GLUT-1 immunoexpression was observed in the MECs compared to PAs and ACCs (p = 0.022). Mean number of microvessels was 66.5 in MECs, 40.4 in PAs, and 21.2 in ACCs (p < 0.001). GLUT-1 expression and angiogenic index showed no significant correlation in the tumors studied. Results suggest that differences in biological behavior of the studied tumors are related to GLUT-1. Benign and malignant salivary gland tumors differ in the angiogenic index; however, angiogenesis may be independent of the tumor cell’s metabolic demand.
KeywordsPleomorphic adenoma Adenoid cystic carcinoma Mucoepidermoid carcinoma Glucose transporter Angiogenic index
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This study was performed in accordance with the ethical standards of the Ethics Committee of the Federal University of Rio Grande do Norte (Permit No. 375/2011) and with the 1964 Helsinki declaration and its later amendments.
Informed consent was obtained from all individual participants included in the study.
- 15.EL-Naggar H, Huvos AG (2005) Adenoid cystic carcinoma. In: World Health Organization classification of tumors: pathology and genetics of head and neck tumors, 3rd edn. IARC Press, Lyon, pp 221–222Google Scholar
- 16.Goode RK, El-Naggar AK (2005) Mucoepidermoid carcinoma. In: World Health Organization classification of tumors: pathology and genetics of head and neck tumors. IARC Press, Lyon, pp 219–220Google Scholar
- 26.Zhang J, Peng B, Chen X (2005) Expressions of nuclear factor kappaB, inducible nitric oxide synthase, and vascular endothelial growth factor in adenoid cystic carcinoma of salivary glands: correlations with the angiogenesis and clinical outcome. Clin Cancer Res 11(20):7334–7343CrossRefPubMedGoogle Scholar
- 28.Dales JP, Garcia S, Bonnier P, Duffaud F, Andrac-Meyer L, Ramuz O, Lavaut MN, Allasia C, Charpin C (2003) CD105 expression is a marker of high metastatic risk and poor outcome in breast carcinomas. Correlations between immunohistochemical analysis and long-term follow-up in a series of 929 patients. Am J Clin Pathol 119(3):374–380CrossRefPubMedGoogle Scholar
- 39.Costa AF, Tasso MG, Mariano FV, Soares AB, Chone CT, Crespo AN, Fresno MF, Llorente JL, Suárez C, de Araújo VC, Hermsen M, Altemani A (2016) Levels and patterns of expression of hypoxia inducible factor 1α, vascular endothelial growth factor, glucose transporter 1 and CD105 in adenoid cystic carcinomas with high grade transformation. Histopathology 60(5):816–825CrossRefGoogle Scholar