European Archives of Oto-Rhino-Laryngology

, Volume 274, Issue 2, pp 977–987 | Cite as

Intensive nutritional care for patients treated with radiotherapy in head and neck cancer: a randomized study and meta-analysis

  • Lise-Marie RousselEmail author
  • Emmanuel Micault
  • Damien Peyronnet
  • David Blanchard
  • Séverine Guarnieri
  • Olivier Choussy
  • Bernard Géry
  • Arnaud Béquignon
  • Corinne Joubert
  • Jean-Jacques Parienti
  • Emmanuel Babin
Head and Neck


Nutritional care improves quality of life (QOL) in head and neck cancer patients treated with radiotherapy. The aim of our study was to determine whether intensive nutritional care (INC) would further improve QOL. In addition to a control group based on European and American guidelines, patients included in the INC group received six meetings with a dietitian. QOL was measured after radiotherapy using the EORTC QLQ-C30. We performed a meta-analysis to determine the best nutritional care. In the 87 patients, the QOL scores, weight, energy, and protein intakes were similar between the INC group (n = 43) and the control group (n = 44). The meta-analysis revealed no heterogeneity and significant differences in QOL (three studies) (p = 0.46) or weight changes after radiotherapy (four studies) (p = 0.06). The nutritional care specified in the European and American guidelines is composed of well-defined recommendations, and appears sufficient to maintain QOL without further intervention.


Malnutrition Quality of life Head and neck neoplasms Radiotherapy 



We thank the “Fondation de France,” “Ligue contre le cancer,” and Caen University Hospital for their financial support. We are grateful to all the dietetics department and Ghislaine Mevielle for data collection.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

405_2016_4278_MOESM1_ESM.pdf (1.4 mb)
Supplementary material 1 (PDF 1398 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Lise-Marie Roussel
    • 1
    • 10
    Email author
  • Emmanuel Micault
    • 1
  • Damien Peyronnet
    • 2
  • David Blanchard
    • 3
  • Séverine Guarnieri
    • 4
  • Olivier Choussy
    • 5
  • Bernard Géry
    • 6
  • Arnaud Béquignon
    • 7
  • Corinne Joubert
    • 8
  • Jean-Jacques Parienti
    • 9
  • Emmanuel Babin
    • 1
    • 10
  1. 1.Department of Otolaryngology-Head and Neck SurgeryCHU de CaenCaenFrance
  2. 2.Department of PharmacyCHU de CaenCaenFrance
  3. 3.Department of Head and Neck SurgeryCenter François BaclesseCaenFrance
  4. 4.Department of RadiotherapyCenter TubianaCaenFrance
  5. 5.Department of Otolaryngology-Head and Neck SurgeryCHU de RouenRouenFrance
  6. 6.Department of RadiotherapyCenter François BaclesseCaenFrance
  7. 7.Department of Otolaryngology-Head and Neck SurgeryCenter TubianaCaenFrance
  8. 8.Department of NutritionCHU de CaenCaenFrance
  9. 9.Department of Biotatistics and Clinical ResearchCHU de CaenCaenFrance
  10. 10.INSERM, U 1086 “Cancer et Prévention”CaenFrance

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