European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 11, pp 3699–3711 | Cite as

Combined intratympanic and systemic use of steroids for idiopathic sudden sensorineural hearing loss: a meta-analysis

  • Yang Gao
  • Dong Liu


The main objective of the meta-analysis was to investigate whether intratympanic steroid injections in combination with systemic steroids would provide an additional advantage over systemic steroid therapy (SST) alone in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). The results will provide a meaningful suggestion in clinical therapy of ISSNHL. The electronic database search was based on the database in OVID Medline, Embase and PubMed up to December 15, 2015 with the goal of identifying all available observational studies examining the effects of combination therapy and SST in ISSNHL patients. Observational studies that compared the pure tone average (PTA) improvement and recovery rate between combination therapy and SST group in ISSNHL patients were selected. Finally we have identified eight eligible studies that focused on comparing the combination therapy and SST in ISSNHL from designated researches. In the PTA improvement group, seven studies have been analyzed to compare the pooled mean differences between two therapy modalities and subgroups based on initial hearing loss and treatment delay. In the recovery rate group, six studies were calculated for pooled risk ratios and subgroup analysis was also conducted. Through our meta-analysis, we have reached the conclusion that combination therapy exhibited better outcomes in PTA improvement than SST alone, especially in severe-profound initial hearing loss cases. Combination therapy also showed advantages in recovery rate. Whether time of treatment delay would influence the PTA improvement and recovery rate requires further researches.


Intratympanic steroid Combination therapy Systemic steroid Idiopathic sudden sensorineural hearing loss 


Compliance with ethical standards

Conflict of interest

The authors have no conflict of interest to declare.

Ethical standards

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Department of BiochemistryMemorial University of NewfoundlandSt. John’sCanada
  2. 2.Princess Margaret Cancer Center, Techna InstituteUniversity Health NetworkTorontoCanada
  3. 3.Department of Otorhinolaryngology, Qilu HospitalShandong UniversityJinanChina
  4. 4.Key Laboratory of OtolaryngologyMinistry of HealthJinanChina

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