European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 10, pp 3293–3297 | Cite as

Treatment of ameloblastoma and ameloblastic carcinoma with radiotherapy

  • William R. Kennedy
  • John W. Werning
  • Frederic J. Kaye
  • William M. MendenhallEmail author
Head and Neck


The purpose of this study is to report our institutional experience using radiotherapy in the treatment of ameloblastoma and ameloblastic carcinoma. Three patients with ameloblastoma and 3 patients with ameloblastic carcinoma were treated with radiotherapy alone (2 patients) or surgery and postoperative radiotherapy (4 patients) at the University of Florida between 1973 and 2007. Follow-up ranged from 4.0 to 13.1 years with a median of 7.8 years. Radiotherapy complications were scored using the Common Terminology Criteria for Adverse Events, version 4.0. Local control was achieved in 4 of the 6 patients. One patient treated with RT alone for an unresectable ameloblastoma developed a local recurrence and metastases in both the cervical lymph nodes and lungs, but had excellent response to dual BRAF/MEK inhibition with dabrafenib and trametinib. Another patient treated with surgery and postoperative radiotherapy for an ameloblastic carcinoma recurred locally without metastasis, but was not salvaged. No significant treatment-related complications were observed. For patients with local recurrence or inadequate margins after surgery, adjuvant radiotherapy provides the potential for disease control. In the setting of metastatic disease, targeted therapies may provide an additional opportunity for salvage.


Head and neck Outcomes Radiation therapy 


Compliance with ethical standards

Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • William R. Kennedy
    • 1
  • John W. Werning
    • 2
  • Frederic J. Kaye
    • 3
  • William M. Mendenhall
    • 1
    Email author
  1. 1.Department of Radiation OncologyUniversity of Florida College of MedicineGainesvilleUSA
  2. 2.Department of OtolaryngologyUniversity of Florida College of MedicineGainesvilleUSA
  3. 3.Department of MedicineUniversity of Florida College of MedicineGainesvilleUSA

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