Advertisement

European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 10, pp 3175–3178 | Cite as

Is neutrophil–lymphocyte ratio associated with the severity of allergic rhinitis in children?

  • Mahmut DogruEmail author
  • Muhammed Fatih Evcimik
  • Ahmet Adnan Cirik
Rhinology

Abstract

Neutrophil lymphocyte ratio (NLR) could be an important measure of systemic inflammation. There is a lack of knowledge about the neutrophil–lymphocyte ratio in rhinitis. We aimed to determine the relationship between the clinical parameters of allergic rhinitis and NLR in children. 438 children who were diagnosed with allergic rhinitis and followed up in our hospital were included in the study. The control group included 180 control children with no evidence of allergic disease. The immunoglobulin E levels, skin prick tests and complete blood count were measured. Mean NLR was 1.77 ± 1.67 in the study group and 1.70 ± 1.65 in the control group. Mean NLR was significantly higher in children with allergic rhinitis compared to controls (p < 0.05). The patients with allergic rhinitis were grouped according to the severity of AR as Group I (mild group) and Group II (moderate/severe group). No statistically significant difference was present between groups in terms of gender, age, familial atopy, exposure to smoke, the presence of asthma and/or eczema, the percentage of eosinophil, serum IgE levels, number of positive sensitivity, and sensitivity to allergens (p > 0.05). However, NLR was significantly higher in the moderate/severe AR compared to mild AR (p < 0.05). Mean NLR was statistically higher in children with allergic rhinitis compared to the control group. In addition, elevated ratio is associated with the severity of allergic rhinitis in children. Neutrophil–lymphocyte can be used as an indicator of inflammation in allergic rhinitis. But further studies are needed in this issue.

Keywords

Neutrophil–lymphocyte ratio Children Severity Inflammation Allergic rhinitis Indicator 

Notes

Acknowledgments

The authors thank the fellows of pediatrics in Zeynep Kamil Woman and Children’s Diseases Training and Research Hospital for their help in the data collection of patients.

Compliance with ethical standards

Financial disclosures

None.

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Bousquet J, Khaltaev N, Cruz AA et al (2008) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update [in collaboration with the World Health Organization, GA(2)LEN and AllerGen]. Allergy 63(Suppl 86):S8–S160CrossRefGoogle Scholar
  2. 2.
    Yıldırım YS, Apuhan T, Koçoğlu E, Simşek T, Kazaz H (2011) High sensitivity C-reactive protein levels in chronic rhinosinusitis and allergic rhinitis. Kulak Burun Bogaz Ihtis Derg. 21(5):266–269CrossRefPubMedGoogle Scholar
  3. 3.
    Büyüköztürk S, Gelincik AA, Genç S, Koçak H, Oneriyidogan Y, Erden S, Dal M, Colakoglu B (2004) Acute phase reactants in allergic airway disease. Tohoku J Exp Med 204(3):209–213CrossRefPubMedGoogle Scholar
  4. 4.
    Steiner I, Sobieska M, Pucher B, Grzegorowski M, Samborski W (2006) Examination of acute phase proteins concentrations in children with allergic rhinitis. Ann Acad Med Stetin 52(2):33–37PubMedGoogle Scholar
  5. 5.
    Yalcin AD, Gumuslu S, Parlak GE, Bisgin A, Yildiz M, Kargi A, Gorczynski RM (2012) Systemic levels of ceruloplasmin oxidase activity in allergic asthma and allergic rhinitis. Immunopharmacol Immunotoxicol 34(6):1047–1053CrossRefPubMedGoogle Scholar
  6. 6.
    Sahan E, Polat S (2014) Neutrophil to lymphocyte ratio is associated with more extensive, severe and complex coronary artery disease and impaired myocardial perfusion. Turk Kardiyol Dern Ars. 42(4):415CrossRefPubMedGoogle Scholar
  7. 7.
    Imtiaz F, Shafique K, Mirza SS, Ayoob Z, Vart P, Rao S (2012) Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. Int Arch Med. 5(1):2CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Uslu AU, Deveci K, Korkmaz S et al (2013) Is neutrophil/lymphocyte ratio associated with subclinical inflammation and amyloidosis in patients with familial Mediterranean fever? Biomed Res Int. 2013:185317CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Biyik M, Ucar R, Solak Y et al (2013) Blood neutrophil-to-lymphocyte ratio independently predicts survival in patients with liver cirrhosis. Eur J Gastroenterol Hepatol 25(4):435–441PubMedGoogle Scholar
  10. 10.
    Kayadibi H, Sertoglu E, Uyanik M, Tapan S (2014) Neutrophil-lymphocyte ratio is useful for the prognosis of patients with hepatocellular carcinoma. World J Gastroenterol 20(28):9631–9632PubMedPubMedCentralGoogle Scholar
  11. 11.
    Zhang XY, Simpson JL, Powell H et al (2014) Full blood count parameters for the detection of asthma inflammatory phenotypes. Clin Exp Allergy 44(9):1137–1145CrossRefPubMedGoogle Scholar
  12. 12.
    Lavinskiene S, Jeroch J, Malakauskas K, Bajoriuniene I, Jackute J, Sakalauskas R (2012) Peripheral blood neutrophil activity during Dermatophagoides pteronyssinus-induced late-phase airwayinflammation in patients with allergic rhinitis and asthma. Inflammation. 35(4):1600–1609CrossRefPubMedGoogle Scholar
  13. 13.
    Lanzkowsky P (2011) Hematological Reference Values. In: Lanzkowsky P (ed) Manuel of Pediatric Hematology and Oncology, 5th edn. Elsevier, San Diego, pp 969–994Google Scholar
  14. 14.
    Amulic B, Cazalet C, Hayes GL, Metzler KD, Zychlinsky A (2012) Neutrophil function: from mechanisms to disease. Annu Rev Immunol 30:459–489CrossRefPubMedGoogle Scholar
  15. 15.
    Gelardi M, Incorvaia C, Fiorella ML, Petrone P, Quaranta N, Russo C, Puccinelli P, Dell’Albani I, Riario-Sforza GG, Cattaneo E, Passalacqua G, Frati F, Italian Academy of Nasal Cytology (2011) The clinical stage of allergic rhinitis is correlated to inflammation as detected by nasal cytology. Inflamm Allergy Drug Targets 10(6):472–476CrossRefPubMedGoogle Scholar
  16. 16.
    Gelardi M, Peroni DG, Incorvaia C et al (2011) Seasonal changes in nasal cytology in mite-allergic patients. Inflamm Allergy Drug Targets 10(6):472–476CrossRefPubMedGoogle Scholar
  17. 17.
    Pelikan Z (2013) Cytological changes in nasal secretions accompanying delayed nasal response to allergen challenge. Am J Rhinol Allergy. 27(5):345–353CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Mahmut Dogru
    • 1
    Email author
  • Muhammed Fatih Evcimik
    • 2
  • Ahmet Adnan Cirik
    • 3
  1. 1.Department of PediatricsZeynep Kamil Woman and Children’s Diseases Training and Research HospitalIstanbulTurkey
  2. 2.Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of MedicineIstanbul Medipol UniversityIstanbulTurkey
  3. 3.Department of Otolaryngology-Head and Neck SurgeryUmraniye Education and Research HospitalIstanbulTurkey

Personalised recommendations