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European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 7, pp 1649–1661 | Cite as

Ameloblastoma: a clinical review and trends in management

  • Andrew C. McClary
  • Robert B. West
  • Ashley C. McClary
  • Jonathan R. Pollack
  • Nancy J. Fischbein
  • Christopher F. Holsinger
  • John Sunwoo
  • A. Dimitrios Colevas
  • Davud Sirjani
Review Article

Abstract

Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

Keywords

Ameloblastoma Head and neck surgery Clinical review Genomics Personalized medicine SHH BRAF 

Notes

Acknowledgments

We would like to thank Norm Cyr for his assistance in preparing the figures presented in the review.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Cusack JW (1827) Report of the amputations of the lower jaw. Dubliln Hop Rec 4:1–38Google Scholar
  2. 2.
    Ivery RH, Churchill HR (1930) The need of a standardized surgical and pathological classification of tumors and anomalies of dental origin. Am Assoc Dent Sch Trans 7:240–245Google Scholar
  3. 3.
    Brazis PW, Miller NR, Lee AG, Holliday MJ (1995) Neuro-ophthalmologic aspects of ameloblastoma. Skull Base Surg 5(4):233–244PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, Mock D, Nikai H (1998) Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 86(6):707–714PubMedCrossRefGoogle Scholar
  5. 5.
    Mosadomi A (1975) Odontogenic tumors in an African population. Analysis of twenty-nine cases seen over a 5-year period. Oral Surg Oral Med Oral Pathol 40(4):502–521PubMedCrossRefGoogle Scholar
  6. 6.
    Barnes L, Everson JW, Reichart P, Sidransky D (eds) (2005) Pathology and genetics of head and neck tumours. IARC Press, LyonGoogle Scholar
  7. 7.
    Daley TD, Wysocki GP, Pringle GA (1994) Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population. Oral Surg Oral Med Oral Pathol 77(3):276–280PubMedCrossRefGoogle Scholar
  8. 8.
    Regezi JA, Kerr DA, Courtney RM (1978) Odontogenic tumors: analysis of 706 cases. J Oral Surg 36(10):771–778PubMedGoogle Scholar
  9. 9.
    Larsson A, Almeren H (1978) Ameloblastoma of the jaws. An analysis of a consecutive series of all cases reported to the Swedish Cancer Registry during 1958–1971. Acta Pathol Microbiol Scand A 86A(5):337–349PubMedGoogle Scholar
  10. 10.
    Wenig BM (2007) Atlas of head and neck pathology, 2nd edn. Elsevier SaundersGoogle Scholar
  11. 11.
    Becelli R, Carboni A, Cerulli G, Perugini M, Iannetti G (2002) Mandibular ameloblastoma: analysis of surgical treatment carried out in 60 patients between 1977 and 1998. J Craniofac Surg 13(3):395–400 PubMedCrossRefGoogle Scholar
  12. 12.
    Olaitan AA, Adeola DS, Adekeye EO (1993) Ameloblastoma: clinical features and management of 315 cases from Kaduna, Nigeria. J Craniomaxillofac Surg 21(8):351–355PubMedCrossRefGoogle Scholar
  13. 13.
    Schafer DR, Thompson LD, Smith BC, Wenig BM (1998) Primary ameloblastoma of the sinonasal tract: a clinicopathologic study of 24 cases. Cancer 82(4):667–674PubMedCrossRefGoogle Scholar
  14. 14.
    Reichart PA, Philipsen HP, Sonner S (1995) Ameloblastoma: biological profile of 3677 cases. Eur J Cancer B Oral Oncol 31B(2):86–99PubMedCrossRefGoogle Scholar
  15. 15.
    Stanley HR, Diehl DL (1965) Ameloblastoma potential of follicular cysts. Oral Surg Oral Med Oral Pathol 20:260–268PubMedCrossRefGoogle Scholar
  16. 16.
    Slootweg PJ, Muller H (1984) Malignant ameloblastoma or ameloblastic carcinoma. Oral Surg Oral Med Oral Pathol 57(2):168–176PubMedCrossRefGoogle Scholar
  17. 17.
    Singer SR, Mupparapu M, Philipone E (2009) Cone beam computed tomography findings in a case of plexiform ameloblastoma. Quintessence Int 40(8):627–630PubMedGoogle Scholar
  18. 18.
    Underhill TE, Katz JO, Pope TL Jr, Dunlap CL (1992) Radiologic findings of diseases involving the maxilla and mandible. AJR Am J Roentgenol 159(2):345–350. doi: 10.2214/ajr.159.2.1632353 PubMedCrossRefGoogle Scholar
  19. 19.
    Carlson ER (1996) Pathologic facial asymmetries. Atlas Oral Maxillofac Surg Clin N Am 4(1):19–35Google Scholar
  20. 20.
    Cohen MA, Hertzanu Y, Mendelsohn DB (1985) Computed tomography in the diagnosis and treatment of mandibular ameloblastoma: report of cases. J Oral Maxillofac Surg 43(10):796–800PubMedCrossRefGoogle Scholar
  21. 21.
    Fujita M, Matsuzaki H, Yanagi Y, Hara M, Katase N, Hisatomi M, Unetsubo T, Konouchi H, Nagatsuka H, Asaumi JI (2013) Diagnostic value of MRI for odontogenic tumours. Dentomaxillofac Radiol 42(5):20120265. doi: 10.1259/dmfr.20120265 PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Kawai T, Kishino M, Hiranuma H, Sasai T, Ishida T (1999) A unique case of desmoplastic ameloblastoma of the mandible: report of a case and brief review of the English language literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87(2):258–263PubMedCrossRefGoogle Scholar
  23. 23.
    Dunfee BL, Sakai O, Pistey R, Gohel A (2006) Radiologic and pathologic characteristics of benign and malignant lesions of the mandible. Radiographics 26(6):1751–1768. doi: 10.1148/rg.266055189 PubMedCrossRefGoogle Scholar
  24. 24.
    Chai Y, Jiang X, Ito Y, Bringas P Jr, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM (2000) Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127(8):1671–1679PubMedGoogle Scholar
  25. 25.
    Ritchie A (1990) Boyd’s text book of pathology, 9th edn. Lea and Febiger, UKGoogle Scholar
  26. 26.
    Bhasker S (1981) Synopsis of oral pathlogy, 6th edn. The CV Mosby, USAGoogle Scholar
  27. 27.
    Gardner DG, Corio RL (1984) Plexiform unicystic ameloblastoma. A variant of ameloblastoma with a low-recurrence rate after enucleation. Cancer 53(8):1730–1735PubMedCrossRefGoogle Scholar
  28. 28.
    Muller H, Slootweg PJ (1985) The ameloblastoma, the controversial approach to therapy. J Maxillofac Surg 13(2):79–84PubMedCrossRefGoogle Scholar
  29. 29.
    Rosenstein T, Pogrel MA, Smith RA, Regezi JA (2001) Cystic ameloblastoma—behavior and treatment of 21 cases. J Oral Maxillofac Surg 59(11):1311–1316. doi: 10.1053/joms.2001.27522 PubMedCrossRefGoogle Scholar
  30. 30.
    Robinson L, Martinez MG (1977) Unicystic ameloblastoma: a prognostically distinct entity. Cancer 40(5):2278–2285PubMedCrossRefGoogle Scholar
  31. 31.
    Ackermann GL, Altini M, Shear M (1988) The unicystic ameloblastoma: a clinicopathological study of 57 cases. J Oral Pathol 17(9–10):541–546PubMedCrossRefGoogle Scholar
  32. 32.
    Carlson ER, Marx RE (2006) The ameloblastoma: primary, curative surgical management. J Oral Maxillofac Surg 64(3):484–494. doi: 10.1016/j.joms.2005.11.032 PubMedCrossRefGoogle Scholar
  33. 33.
    Waldron CA, el-Mofty SK (1987) A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant. Oral Surg Oral Med Oral Pathol 63(4):441–451PubMedCrossRefGoogle Scholar
  34. 34.
    Philipsen HP, Reichart PA, Takata T (2001) Desmoplastic ameloblastoma (including “hybrid” lesion of ameloblastoma). Biological profile based on 100 cases from the literature and own files. Oral Oncol 37(5):455–460PubMedCrossRefGoogle Scholar
  35. 35.
    Keszler A, Paparella ML, Dominguez FV (1996) Desmoplastic and non-desmoplastic ameloblastoma: a comparative clinicopathological analysis. Oral Dis 2(3):228–231PubMedCrossRefGoogle Scholar
  36. 36.
    Takata T, Miyauchi M, Ito H, Ogawa I, Kudo Y, Zhao M, Sato S, Takekoshi T, Nikai H, Tanimoto K (1999) Clinical and histopathological analyses of desmoplastic ameloblastoma. Pathol Res Pract 195(10):669–675. doi: 10.1016/S0344-0338(99)80057-0 PubMedCrossRefGoogle Scholar
  37. 37.
    Buchner A, Merrell PW, Carpenter WM (2006) Relative frequency of peripheral odontogenic tumors: a study of 45 new cases and comparison with studies from the literature. J Oral Pathol Med 35(7):385–391. doi: 10.1111/j.1600-0714.2006.00437.x PubMedCrossRefGoogle Scholar
  38. 38.
    Fernandes AM, Duarte EC, Pimenta FJ, Souza LN, Santos VR, Mesquita RA, de Aguiar MC (2005) Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Medicine 34(10):583–587. doi: 10.1111/j.1600-0714.2005.00357.x CrossRefGoogle Scholar
  39. 39.
    LeCorn DW, Bhattacharyya I, Vertucci FJ (2006) Peripheral ameloblastoma: a case report and review of the literature. J Endod 32(2):152–154. doi: 10.1016/j.joen.2005.10.028 PubMedCrossRefGoogle Scholar
  40. 40.
    Eliasson AH, Moser RJ 3rd, Tenholder MF (1989) Diagnosis and treatment of metastatic ameloblastoma. South Med J 82(9):1165–1168PubMedCrossRefGoogle Scholar
  41. 41.
    Elzay RP (1982) Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol 54(3):299–303PubMedCrossRefGoogle Scholar
  42. 42.
    Kruse AL, Zwahlen RA, Gratz KW (2009) New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years. Head Neck Oncol 1:31. doi: 10.1186/1758-3284-1-31 PubMedPubMedCentralCrossRefGoogle Scholar
  43. 43.
    Ward BB, Edlund S, Sciubba J, Helman JI (2007) Ameloblastic carcinoma (primary type) isolated to the anterior maxilla: case report with review of the literature. J Oral Maxillofac Surg 65(9):1800–1803. doi: 10.1016/j.joms.2006.06.265 PubMedCrossRefGoogle Scholar
  44. 44.
    Dhir K, Sciubba J, Tufano RP (2003) Ameloblastic carcinoma of the maxilla. Oral Oncol 39(7):736–741PubMedCrossRefGoogle Scholar
  45. 45.
    Henderson JM, Sonnet JR, Schlesinger C, Ord RA (1999) Pulmonary metastasis of ameloblastoma: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88(2):170–176PubMedCrossRefGoogle Scholar
  46. 46.
    Bruce RA, Jackson IT (1991) Ameloblastic carcinoma. Report of an aggressive case and review of the literature. J Craniomaxillofac Surg 19(6):267–271PubMedCrossRefGoogle Scholar
  47. 47.
    Clay RP, Weiland LH, Jackson IT (1989) Ameloblastoma metastatic to the lung. Ann Plast Surg 22(2):160–162PubMedCrossRefGoogle Scholar
  48. 48.
    Kunze E, Donath K, Luhr HG, Engelhardt W, De Vivie R (1985) Biology of metastasizing ameloblastoma. Pathol Res Pract 180(5):526–535. doi: 10.1016/S0344-0338(85)80017-0 PubMedCrossRefGoogle Scholar
  49. 49.
    Laughlin EH (1989) Metastasizing ameloblastoma. Cancer 64(3):776–780PubMedCrossRefGoogle Scholar
  50. 50.
    Kahn MA (1989) Ameloblastoma in young persons: a clinicopathologic analysis and etiologic investigation. Oral Surg Oral Med Oral Pathol 67(6):706–715PubMedCrossRefGoogle Scholar
  51. 51.
    Correnti M, Rossi M, Avila M, Perrone M, Rivera H (2010) Human papillomavirus in ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(3):e20–e24. doi: 10.1016/j.tripleo.2010.04.030 PubMedCrossRefGoogle Scholar
  52. 52.
    Kahn MA (1992) Demonstration of human papillomavirus DNA in a peripheral ameloblastoma by in situ hybridization. Hum Pathol 23(2):188–191PubMedCrossRefGoogle Scholar
  53. 53.
    Namin AK, Azad TM, Eslami B, Sarkarat F, Shahrokhi M, Kashanian F (2003) A study of the relationship between ameloblastoma and human papilloma virus. J Oral Maxillofac Surg 61(4):467–470. doi: 10.1053/joms.2003.50011 PubMedCrossRefGoogle Scholar
  54. 54.
    Sand L, Jalouli J, Larsson PA, Magnusson B, Hirsch JM (2000) Presence of human papilloma viruses in intraosseous ameloblastoma. J Oral Maxillofac Surg 58(10):1129–1134. doi: 10.1053/joms.2000.9573 PubMedCrossRefGoogle Scholar
  55. 55.
    Migaldi M, Pecorari M, Rossi G, Maiorana A, Bettelli S, Tamassia MG, De Gaetani C, Leocata P, Portolani M (2005) Does HPV play a role in the etiopathogenesis of ameloblastoma? An immunohistochemical, in situ hybridization and polymerase chain reaction study of 18 cases using laser capture microdissection. Mod Pathol 18(2):283–289. doi: 10.1038/modpathol.3800241 PubMedCrossRefGoogle Scholar
  56. 56.
    Kurppa KJ, Caton J, Morgan PR, Ristimaki A, Ruhin B, Kellokoski J, Elenius K, Heikinheimo K (2014) High frequency of BRAF V600E mutations in ameloblastoma. J Pathol 232(5):492–498. doi: 10.1002/path.4317 PubMedPubMedCentralCrossRefGoogle Scholar
  57. 57.
    Sweeney RT, McClary AC, Myers BR, Biscocho J, Neahring L, Kwei KA, Qu K, Gong X, Ng T, Jones CD, Varma S, Odegaard JI, Sugiyama T, Koyota S, Rubin BP, Troxell ML, Pelham RJ, Zehnder JL, Beachy PA, Pollack JR, West RB (2014) Identification of recurrent SMO and BRAF mutations in ameloblastomas. Nat Genet 46(7):722–725. doi: 10.1038/ng.2986 PubMedPubMedCentralCrossRefGoogle Scholar
  58. 58.
    Brown NA, Rolland DC, McHugh JB, Weigelin HC, Zhao LL, Lim MS, Elenitoba-Johnson KS, Betz BL (2014) Activating FGFR2-RAS-BRAF mutations in ameloblastoma. Clin Cancer Res. doi: 10.1158/1078-0432.CCR-14-1069 Google Scholar
  59. 59.
    Cobourne MT, Hardcastle Z, Sharpe PT (2001) Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J Dent Res 80(11):1974–1979PubMedCrossRefGoogle Scholar
  60. 60.
    Heikinheimo K, Jee KJ, Niini T, Aalto Y, Happonen RP, Leivo I, Knuutila S (2002) Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray. J Dent Res 81(8):525–530PubMedCrossRefGoogle Scholar
  61. 61.
    Daya-Grosjean L, Couve-Privat S (2005) Sonic hedgehog signaling in basal cell carcinomas. Cancer Lett 225(2):181–192. doi: 10.1016/j.canlet.2004.10.003 PubMedCrossRefGoogle Scholar
  62. 62.
    Dassule HR, Lewis P, Bei M, Maas R, McMahon AP (2000) Sonic hedgehog regulates growth and morphogenesis of the tooth. Development 127(22):4775–4785PubMedGoogle Scholar
  63. 63.
    Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson EK, Cooper MK, Gaffield W, Westphal H, Beachy PA, Dlugosz AA (1999) Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol 205(1):1–9. doi: 10.1006/dbio.1998.9103 PubMedCrossRefGoogle Scholar
  64. 64.
    Gorlin RJ, Goltz RW (1960) Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib. A syndrome. N Engl J Med 262:908–912. doi: 10.1056/NEJM196005052621803 PubMedCrossRefGoogle Scholar
  65. 65.
    Ally MS, Tang JY, Joseph T, Thompson B, Lindgren J, Raphael MA, Ulerio G, Chanana AM, Mackay-Wiggan JM, Bickers DR, Epstein EH Jr (2014) The use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome. JAMA Dermatol 150(5):542–545. doi: 10.1001/jamadermatol.2013.7444 PubMedPubMedCentralCrossRefGoogle Scholar
  66. 66.
    Farias LC, Gomes CC, Brito JA, Galvao CF, Diniz MG, de Castro WH, Bernardes Vde F, De Marco LA, Gomez RS (2012) Loss of heterozygosity of the PTCH gene in ameloblastoma. Hum Pathol 43(8):1229–1233. doi: 10.1016/j.humpath.2011.08.026 PubMedCrossRefGoogle Scholar
  67. 67.
    Carvalhais J, Aguiar M, Araujo V, Araujo N, Gomez R (1999) p53 and MDM2 expression in odontogenic cysts and tumours. Oral Dis 5(3):218–222PubMedCrossRefGoogle Scholar
  68. 68.
    Appel T, Gath R, Wernert N, Martini M, Berge S (2004) Molecular biological and immunohistochemical analysis of tp53 in human ameloblastomas. Mund Kiefer Gesichtschir 8(3):167–172. doi: 10.1007/s10006-004-0539-7 PubMedCrossRefGoogle Scholar
  69. 69.
    Shibata T, Nakata D, Chiba I, Yamashita T, Abiko Y, Tada M, Moriuchi T (2002) Detection of TP53 mutation in ameloblastoma by the use of a yeast functional assay. J Oral Pathol Med 31(9):534–538PubMedCrossRefGoogle Scholar
  70. 70.
    Sehdev MK, Huvos AG, Strong EW, Gerold FP, Willis GW (1974) Proceedings: Ameloblastoma of maxilla and mandible. Cancer 33(2):324–333PubMedCrossRefGoogle Scholar
  71. 71.
    Shatkin S, Hoffmeister FS (1965) Ameloblastoma: a rational approach to therapy. Oral Surg Oral Med Oral Pathol 20(4):421–435PubMedCrossRefGoogle Scholar
  72. 72.
    Mehlisch DR, Dahlin DC, Masson JK (1972) Ameloblastoma: a clinicopathologic report. J Oral Surg 30(1):9–22PubMedGoogle Scholar
  73. 73.
    Ueno S, Mushimoto K, Shirasu R (1989) Prognostic evaluation of ameloblastoma based on histologic and radiographic typing. J Oral Maxillofac Surg 47(1):11–15PubMedCrossRefGoogle Scholar
  74. 74.
    Eckardt AM, Kokemuller H, Flemming P, Schultze A (2009) Recurrent ameloblastoma following osseous reconstruction—a review of twenty years. J Craniomaxillofac Surg 37(1):36–41. doi: 10.1016/j.jcms.2008.07.009 PubMedCrossRefGoogle Scholar
  75. 75.
    Nakamura N, Higuchi Y, Mitsuyasu T, Sandra F, Ohishi M (2002) Comparison of long-term results between different approaches to ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93(1):13–20PubMedCrossRefGoogle Scholar
  76. 76.
    Curi MM, Dib LL, Pinto DS (1997) Management of solid ameloblastoma of the jaws with liquid nitrogen spray cryosurgery. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84(4):339–344PubMedCrossRefGoogle Scholar
  77. 77.
    Pogrel MA (1993) The use of liquid nitrogen cryotherapy in the management of locally aggressive bone lesions. J Oral Maxillofac Surg 51(3):269–273 PubMedCrossRefGoogle Scholar
  78. 78.
    Lau SL, Samman N (2006) Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review. Int J Oral Maxillofac Surg 35(8):681–690. doi: 10.1016/j.ijom.2006.02.016 PubMedCrossRefGoogle Scholar
  79. 79.
    Chapelle KA, Stoelinga PJ, de Wilde PC, Brouns JJ, Voorsmit RA (2004) Rational approach to diagnosis and treatment of ameloblastomas and odontogenic keratocysts. Br J Oral Maxillofac Surg 42(5):381–390. doi: 10.1016/j.bjoms.2004.04.005 PubMedCrossRefGoogle Scholar
  80. 80.
    Huffman GG, Thatcher JW (1974) Ameloblastoma—the conservative surgical approach to treatment: report of four cases. J Oral Surg 32(11):850–854PubMedGoogle Scholar
  81. 81.
    Sham E, Leong J, Maher R, Schenberg M, Leung M, Mansour AK (2009) Mandibular ameloblastoma: clinical experience and literature review. ANZ J Surg 79(10):739–744. doi: 10.1111/j.1445-2197.2009.05061.x PubMedCrossRefGoogle Scholar
  82. 82.
    Gardner DG, Pecak AM (1980) The treatment of ameloblastoma based on pathologic and anatomic principles. Cancer 46(11):2514–2519PubMedCrossRefGoogle Scholar
  83. 83.
    Williams TP (1993) Management of ameloblastoma: a changing perspective. J Oral Maxillofac Surg 51(10):1064–1070PubMedCrossRefGoogle Scholar
  84. 84.
    Becelli R, Morello R, Renzi G, Matarazzo G, Dominici C (2011) Treatment of recurrent mandibular ameloblastoma with segmental resection and revascularized fibula free flap. J Craniofac Surg 22(3):1163–1165. doi: 10.1097/SCS.0b013e318210bc34 PubMedCrossRefGoogle Scholar
  85. 85.
    Vayvada H, Mola F, Menderes A, Yilmaz M (2006) Surgical management of ameloblastoma in the mandible: segmental mandibulectomy and immediate reconstruction with free fibula or deep circumflex iliac artery flap (evaluation of the long-term esthetic and functional results). J Oral Maxillofac Surg 64(10):1532–1539. doi: 10.1016/j.joms.2005.11.065 PubMedCrossRefGoogle Scholar
  86. 86.
    Urken ML, Buchbinder D, Weinberg H, Vickery C, Sheiner A, Parker R, Schaefer J, Som P, Shapiro A, Lawson W et al (1991) Functional evaluation following microvascular oromandibular reconstruction of the oral cancer patient: a comparative study of reconstructed and nonreconstructed patients. Laryngoscope 101(9):935–950. doi: 10.1288/00005537-199109000-00004 PubMedCrossRefGoogle Scholar
  87. 87.
    Urken ML, Buchbinder D, Costantino PD, Sinha U, Okay D, Lawson W, Biller HF (1998) Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Arch Otolaryngol Head Neck Surg 124(1):46–55PubMedCrossRefGoogle Scholar
  88. 88.
    Carlson ER (2000) Ameloblastoma. In: Symposium on odontogenic tumors, AAOMS 82nd annual meeting and scientific sessions, San Francisco, CA, September 23, 2000Google Scholar
  89. 89.
    Zwahlen RA, Gratz KW (2002) Maxillary ameloblastomas: a review of the literature and of a 15-year database. J Craniomaxillofac Surg 30(5):273–279PubMedCrossRefGoogle Scholar
  90. 90.
    Ndukwe KC, Adebiyi EK, Ugboko VI, Adeyemo WL, Ajayi FO, Ladeinde AL, Okojie VN, Ajike SO, Olasoji HO (2010) Ameloblastic carcinoma: a multicenter Nigerian study. J Oral Maxillofac Surg 68(9):2111–2114. doi: 10.1016/j.joms.2009.09.028 PubMedCrossRefGoogle Scholar
  91. 91.
    Gardner DG (1984) A pathologist’s approach to the treatment of ameloblastoma. J Oral Maxillofac Surg 42(3):161–166PubMedCrossRefGoogle Scholar
  92. 92.
    Black CC, Addante RR, Mohila CA (2010) Intraosseous ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(5):585–592. doi: 10.1016/j.tripleo.2010.02.040 PubMedCrossRefGoogle Scholar
  93. 93.
    Marx RE, Smith BH, Smith BR, Fridrich KL (1993) Swelling of the retromolar region and cheek associated with limited opening. J Oral Maxillofac Surg 51(3):304–309PubMedCrossRefGoogle Scholar
  94. 94.
    Forrest LA, Schuller DE, Karanfilov B, Lucas JG (1997) Update on intraoperative analysis of mandibular margins. Am J Otolaryngol 18(6):396–399PubMedCrossRefGoogle Scholar
  95. 95.
    Gephardt GN, Zarbo RJ (1996) Interinstitutional comparison of frozen section consultations. A college of American Pathologists Q-Probes study of 90,538 cases in 461 institutions. Arch Pathol Lab Med 120(9):804–809PubMedGoogle Scholar
  96. 96.
    Ueno S, Nakamura S, Mushimoto K, Shirasu R (1986) A clinicopathologic study of ameloblastoma. J Oral Maxillofac Surg 44(5):361–365PubMedCrossRefGoogle Scholar
  97. 97.
    Gold L, Upton GW, Marx RE (1991) Standardized surgical terminology for the excision of lesions in bone: an argument for accuracy in reporting. J Oral Maxillofac Surg 49(11):1214–1217PubMedCrossRefGoogle Scholar
  98. 98.
    Winther C, Graem N (2011) Accuracy of frozen section diagnosis: a retrospective analysis of 4785 cases. APMIS 119(4–5):259–262. doi: 10.1111/j.1600-0463.2011.02725.x PubMedCrossRefGoogle Scholar
  99. 99.
    Guthrie D, Peacock ZS, Sadow P, Dodson TB, August M (2012) Preoperative incisional and intraoperative frozen section biopsy techniques have comparable accuracy in the diagnosis of benign intraosseous jaw pathology. J Oral Maxillofac Surg 70(11):2566–2572. doi: 10.1016/j.joms.2011.11.023 PubMedCrossRefGoogle Scholar
  100. 100.
    Zemann W, Feichtinger M, Kowatsch E, Karcher H (2007) Extensive ameloblastoma of the jaws: surgical management and immediate reconstruction using microvascular flaps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(2):190–196. doi: 10.1016/j.tripleo.2006.05.004 PubMedCrossRefGoogle Scholar
  101. 101.
    Pogrel MA, Podlesh S, Anthony JP, Alexander J (1997) A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. J Oral Maxillofac Surg 55(11):1200–1206PubMedCrossRefGoogle Scholar
  102. 102.
    Chana JS, Chang YM, Wei FC, Shen YF, Chan CP, Lin HN, Tsai CY, Jeng SF (2004) Segmental mandibulectomy and immediate free fibula osteoseptocutaneous flap reconstruction with endosteal implants: an ideal treatment method for mandibular ameloblastoma. Plast Reconstr Surg 113(1):80–87. doi: 10.1097/01.PRS.0000097719.69616.29 PubMedCrossRefGoogle Scholar
  103. 103.
    Foster RD, Anthony JP, Sharma A, Pogrel MA (1999) Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction: an outcome analysis of primary bony union and endosseous implant success. Head Neck 21(1):66–71PubMedCrossRefGoogle Scholar
  104. 104.
    Hidalgo DA, Pusic AL (2002) Free-flap mandibular reconstruction: a 10-year follow-up study. Plastic and reconstructive surgery 110(2):438–449PubMedCrossRefGoogle Scholar
  105. 105.
    Nastri AL, Wiesenfeld D, Radden BG, Eveson J, Scully C (1995) Maxillary ameloblastoma: a retrospective study of 13 cases. Br J Oral Maxillofac Surg 33(1):28–32PubMedCrossRefGoogle Scholar
  106. 106.
    Miyamoto CT, Brady LW, Markoe A, Salinger D (1991) Ameloblastoma of the jaw. Treatment with radiation therapy and a case report. Am J Clin Oncol 14(3):225–230PubMedCrossRefGoogle Scholar
  107. 107.
    Pinsolle J, Michelet V, Coustal B, Siberchicot F, Michelet FX (1995) Treatment of ameloblastoma of the jaws. Arch Otolaryngol Head Neck Surg 121(9):994–996PubMedCrossRefGoogle Scholar
  108. 108.
    Ueda M, Kaneda T (1991) Combined chemotherapy and radiotherapy for advanced maxillary ameloblastoma. A case report. J Craniomaxillofac surg 19(6):272–274PubMedCrossRefGoogle Scholar
  109. 109.
    Atkinson CH, Harwood AR, Cummings BJ (1984) Ameloblastoma of the jaw. A reappraisal of the role of megavoltage irradiation. Cancer 53(4):869–873PubMedCrossRefGoogle Scholar
  110. 110.
    Gardner DG (1988) Radiotherapy in the treatment of ameloblastoma. Int J Oral Maxillofac Surg 17(3):201–205PubMedCrossRefGoogle Scholar
  111. 111.
    Huvos AG, Woodard HQ, Cahan WG, Higinbotham NL, Stewart FW, Butler A, Bretsky SS (1985) Postradiation osteogenic sarcoma of bone and soft tissues. A clinicopathologic study of 66 patients. Cancer 55(6):1244–1255PubMedCrossRefGoogle Scholar
  112. 112.
    Philip M, Morris C, Werning J, Mendenhall W (2005) Radiotherapy in the treatment of ameloblastoma and ameloblastic carcinoma. Hong Kong J Radiol 8(3):157Google Scholar
  113. 113.
    Cizmecy O, Aslan A, Onel D, Demiryont M (2004) Ameloblastic carcinoma ex ameloblastoma of the mandible: case report. Otolaryngol Head Neck Surg 130(5):633–634. doi: 10.1016/j.otohns.2003.11.012 PubMedCrossRefGoogle Scholar
  114. 114.
    Cox DP, Muller S, Carlson GW, Murray D (2000) Ameloblastic carcinoma ex ameloblastoma of the mandible with malignancy-associated hypercalcemia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90(6):716–722. doi: 10.1067/moe.2000.109076 PubMedCrossRefGoogle Scholar
  115. 115.
    Akrish S, Buchner A, Shoshani Y, Vered M, Dayan D (2007) Ameloblastic carcinoma: report of a new case, literature review, and comparison to ameloblastoma. J Oral Maxillofac Surg 65(4):777–783. doi: 10.1016/j.joms.2005.11.116 PubMedCrossRefGoogle Scholar
  116. 116.
    Corio RL, Goldblatt LI, Edwards PA, Hartman KS (1987) Ameloblastic carcinoma: a clinicopathologic study and assessment of eight cases. Oral Surg Oral Med Oral Pathol 64(5):570–576PubMedCrossRefGoogle Scholar
  117. 117.
    Naik V, Kale AD (2007) Ameloblastic carcinoma: a case report. Quintessence Int 38(10):873–879PubMedGoogle Scholar
  118. 118.
    Datta R, Winston JS, Diaz-Reyes G, Loree TR, Myers L, Kuriakose MA, Rigual NR, Hicks WL Jr (2003) Ameloblastic carcinoma: report of an aggressive case with multiple bony metastases. Am J Otolaryngol 24(1):64–69. doi: 10.1053/ajot.2003.15 PubMedCrossRefGoogle Scholar
  119. 119.
    Goldenberg D, Sciubba J, Koch W, Tufano RP (2004) Malignant odontogenic tumors: a 22-year experience. Laryngoscope 114(10):1770–1774. doi: 10.1097/00005537-200410000-00018 PubMedCrossRefGoogle Scholar
  120. 120.
    Dorner L, Sear AJ, Smith GT (1988) A case of ameloblastic carcinoma with pulmonary metastases. Br J Oral Maxillofac Surg 26(6):503–510PubMedCrossRefGoogle Scholar
  121. 121.
    McClatchey KD, Sullivan MJ, Paugh DR (1989) Peripheral ameloblastic carcinoma: a case report of a rare neoplasm. J Otolaryngol 18(3):109–111PubMedGoogle Scholar
  122. 122.
    Lee L, Maxymiw WG, Wood RE (1990) Ameloblastic carcinoma of the maxilla metastatic to the mandible. Case report. J Craniomaxillofac surg 18(6):247–250PubMedCrossRefGoogle Scholar
  123. 123.
    Nagai N, Takeshita N, Nagatsuka H, Inoue M, Nishijima K, Nojima T, Yamasaki M, Hoh C (1991) Ameloblastic carcinoma: case report and review. J Oral Pathol Med 20(9):460–463PubMedCrossRefGoogle Scholar
  124. 124.
    Gandy SR, Keller EE, Unni KK (1992) Ameloblastic carcinoma: report of two cases. J Oral Maxillofac Surg 50(10):1097–1102PubMedCrossRefGoogle Scholar
  125. 125.
    Ingram EA, Evans ML, Zitsch RP 3rd (1996) Fine-needle aspiration cytology of ameloblastic carcinoma of the maxilla: a rare tumor. Diagn Cytopathol 14(3):249–252. doi: 10.1002/(SICI)1097-0339(199604)14:3<249:AID-DC10>3.0.CO;2-L PubMedCrossRefGoogle Scholar
  126. 126.
    Lau SK, Tideman H, Wu PC (1998) Ameloblastic carcinoma of the jaws. A report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85(1):78–81PubMedCrossRefGoogle Scholar
  127. 127.
    Infante-Cossio P, Hernandez-Guisado JM, Fernandez-Machin P, Garcia-Perla A, Rollon-Mayordomo A, Gutierrez-Perez JL (1998) Ameloblastic carcinoma of the maxilla: a report of 3 cases. J Craniomaxillofac Surg 26(3):159–162PubMedCrossRefGoogle Scholar
  128. 128.
    Simko EJ, Brannon RB, Eibling DE (1998) Ameloblastic carcinoma of the mandible. Head Neck 20(7):654–659PubMedCrossRefGoogle Scholar
  129. 129.
    Sastre J, Munoz M, Naval L, Adrados M (2002) Ameloblastic carcinoma of the maxilla: report of a case. J Oral Maxillofac Surg 60(1):102–104PubMedCrossRefGoogle Scholar
  130. 130.
    Avon SL, McComb J, Clokie C (2003) Ameloblastic carcinoma: case report and literature review. J Can Dent Assoc 69(9):573–576PubMedGoogle Scholar
  131. 131.
    Oginni FO, Ugboko VI, Owotade JF, Adebiyi KE (2003) Ameloblastic carcinoma of the jaws. A report of three Nigerian cases. Odontostomatol Trop 26(104):19–22PubMedGoogle Scholar
  132. 132.
    Carinci F, Palmieri A, Delaiti G, Rubini C, Fioroni M, Martinelli M, Pezzetti F, Scapoli L, Piattelli A (2004) Expression profiling of ameloblastic carcinoma. J Craniofac Surg 15(2):264–269PubMedCrossRefGoogle Scholar
  133. 133.
    Uzum N, Akyol G, Asal K, Koybasioglu A (2005) Ameloblastic carcinoma containing melanocyte and melanin pigment in the mandible: a case report and review of the literature. J Oral Pathol Med 34(10):618–620. doi: 10.1111/j.1600-0714.2005.00306.x PubMedCrossRefGoogle Scholar
  134. 134.
    Ozlugedik S, Ozcan M, Basturk O, Deren O, Kaptanoglu E, Adanali G, Unal A (2005) Ameloblastic carcinoma arising from anterior skull base. Skull base 15(4):269–272. doi: 10.1055/s-2005-918621 PubMedPubMedCentralCrossRefGoogle Scholar
  135. 135.
    Suomalainen A, Hietanen J, Robinson S, Peltola JS (2006) Ameloblastic carcinoma of the mandible resembling odontogenic cyst in a panoramic radiograph. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101(5):638–642. doi: 10.1016/j.tripleo.2005.07.033 PubMedCrossRefGoogle Scholar
  136. 136.
    Miyake T, Tanaka Y, Kato K, Tanaka M, Sato Y, Ijiri R, Inayama Y, Ito Y, Aoki S, Kawabe R, Tohnai I (2006) Gene mutation analysis and immunohistochemical study of beta-catenin in odontogenic tumors. Pathol Int 56(12):732–737. doi: 10.1111/j.1440-1827.2006.02039.x PubMedCrossRefGoogle Scholar
  137. 137.
    Hall JM, Weathers DR, Unni KK (2007) Ameloblastic carcinoma: an analysis of 14 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(6):799–807. doi: 10.1016/j.tripleo.2006.11.048 PubMedCrossRefGoogle Scholar
  138. 138.
    Benlyazid A, Lacroix-Triki M, Aziza R, Gomez-Brouchet A, Guichard M, Sarini J (2007) Ameloblastic carcinoma of the maxilla: case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104(6):e17–e24. doi: 10.1016/j.tripleo.2007.05.026 PubMedCrossRefGoogle Scholar
  139. 139.
    Yazici N, Karagoz B, Varan A, Yilmaz T, Ozturk A, Usubutun A, Buyukpamukcu M (2008) Maxillary ameloblastic carcinoma in a child. Pediatr Blood Cancer 50(1):175–176. doi: 10.1002/pbc.20889 PubMedCrossRefGoogle Scholar
  140. 140.
    Gardner DG (1995) Canine acanthomatous epulis. The only common spontaneous ameloblastoma in animals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79(5):612–615PubMedCrossRefGoogle Scholar
  141. 141.
    Gall JA, Sartiano GP, Shreiner DP (1975) Ameloblastoma of the mandible with pulmonary metastasis. Oncology 32(3–4):118–126PubMedGoogle Scholar
  142. 142.
    Ramadas K, Jose C, Subhashini J, Chandi SM, Viswanathan FR (1990) Pulmonary metastases from ameloblastoma of the mandible treated with cisplatin, adriamycin, and cyclophosphamide. Cancer 66(7):1475–1479PubMedCrossRefGoogle Scholar
  143. 143.
    Grünwald V, Le Blanc S, Karstens JH, Weihkopf T, Kuske M, Ganser A, Schoffski P (2001) Metastatic malignant ameloblastoma responding to chemotherapy with paclitaxel and carboplatin. Ann Oncol 12(10):1489–1491PubMedCrossRefGoogle Scholar
  144. 144.
    Campbell D, Jeffrey RR, Wallis F, Hulks G, Kerr KM (2003) Metastatic pulmonary ameloblastoma. An unusual case. Br J Oral Maxillofac Surg 41(3):194–196PubMedCrossRefGoogle Scholar
  145. 145.
    Amzerin M, Fadoukhair Z, Belbaraka R, Iraqui M, Boutayeb S, M’Rabti H, Kebdani T, Hassouni K, Benjaafar N, El Gueddari BK, Errihani H (2011) Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature. J Med Case Rep 5:491. doi: 10.1186/1752-1947-5-491 PubMedPubMedCentralCrossRefGoogle Scholar
  146. 146.
    Van Dam SD, Unni KK, Keller EE (2010) Metastasizing (malignant) ameloblastoma: review of a unique histopathologic entity and report of Mayo Clinic experience. J Oral Maxillofac Surg 68(12):2962–2974. doi: 10.1016/j.joms.2010.05.084 PubMedCrossRefGoogle Scholar
  147. 147.
    Ciment LM, Ciment AJ (2002) Malignant ameloblastoma metastatic to the lungs 29 years after primary resection: a case report. Chest 121(4):1359–1361PubMedCrossRefGoogle Scholar
  148. 148.
    Jackson IT, Callan PP, Forte RA (1996) An anatomical classification of maxillary ameloblastoma as an aid to surgical treatment. J Craniomaxillofac Surg 24(4):230–236PubMedCrossRefGoogle Scholar
  149. 149.
    Daramola JO, Ajagbe HA, Oluwasanmi JO (1980) Recurrent ameloblastoma of the jaws—a review of 22 cases. Plast Reconstr Surg 65(5):577–579PubMedCrossRefGoogle Scholar
  150. 150.
    Frantz V, Stix L (1932) Adamantinoma: a case of fifty-one years’duration. Arch Surg 25(5):890–897CrossRefGoogle Scholar
  151. 151.
    Nakasato S, Okamura S, Kudo K, Takeda Y (1991) Gigantic ameloblastoma associated with secondary hypoproteinemia. J Oral Maxillofac Surg 49(7):764–767PubMedCrossRefGoogle Scholar
  152. 152.
    Inoue N, Shimojyo M, Iwai H, Ohtsuki H, Yasumizu R, Shintaku M, Taniguchi N, Inada M, Arika T, Morita S et al (1988) Malignant ameloblastoma with pulmonary metastasis and hypercalcemia. Report of an autopsy case and review of the literature. Am J Clin Pathol 90(4):474–481PubMedCrossRefGoogle Scholar
  153. 153.
    Harada K, Suda S, Kayano T, Nagura H, Enomoto S (1989) Ameloblastoma with metastasis to the lung and associated hypercalcemia. J Oral Maxillofac Surg 47(10):1083–1087PubMedCrossRefGoogle Scholar
  154. 154.
    Ramon Y, Mozes M, Buchner A (1964) A fatal case of Ameloblastoma (Adamantinoma). Br J Plast Surg 17:320–324PubMedCrossRefGoogle Scholar
  155. 155.
    Bredenkamp JK, Zimmerman MC, Mickel RA (1989) Maxillary ameloblastoma. A potentially lethal neoplasm. Arch Otolaryngol Head Neck Surg 115(1):99–104PubMedCrossRefGoogle Scholar
  156. 156.
    Lin Y, He JF, Li ZY, Liu JH (2013) Ameloblastoma with varied sites of metastasis: report of two cases and literature review. J Craniomaxillofac Surg. doi: 10.1016/j.jcms.2013.10.010 Google Scholar
  157. 157.
    Nielsen TO, West RB (2010) Translating gene expression into clinical care: sarcomas as a paradigm. J Clin Oncol 28(10):1796–1805. doi: 10.1200/JCO.2009.26.1917 PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Andrew C. McClary
    • 2
  • Robert B. West
    • 2
  • Ashley C. McClary
    • 4
  • Jonathan R. Pollack
    • 2
  • Nancy J. Fischbein
    • 5
  • Christopher F. Holsinger
    • 1
  • John Sunwoo
    • 1
  • A. Dimitrios Colevas
    • 3
  • Davud Sirjani
    • 1
  1. 1.Division of Head and Neck Surgery, Department of OtolaryngologyStanford UniversityStanfordUSA
  2. 2.Department of PathologyStanford UniversityStanfordUSA
  3. 3.Division of Oncology, Department of MedicineStanford UniversityStanfordUSA
  4. 4.Department of PediatricsStanford UniversityStanfordUSA
  5. 5.Department of RadiologyStanford UniversityStanfordUSA

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