European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 7, pp 1649–1661 | Cite as

Ameloblastoma: a clinical review and trends in management

  • Andrew C. McClaryEmail author
  • Robert B. West
  • Ashley C. McClary
  • Jonathan R. Pollack
  • Nancy J. Fischbein
  • Christopher F. Holsinger
  • John Sunwoo
  • A. Dimitrios Colevas
  • Davud SirjaniEmail author
Review Article


Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.


Ameloblastoma Head and neck surgery Clinical review Genomics Personalized medicine SHH BRAF 



We would like to thank Norm Cyr for his assistance in preparing the figures presented in the review.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical statement

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Andrew C. McClary
    • 2
    Email author
  • Robert B. West
    • 2
  • Ashley C. McClary
    • 4
  • Jonathan R. Pollack
    • 2
  • Nancy J. Fischbein
    • 5
  • Christopher F. Holsinger
    • 1
  • John Sunwoo
    • 1
  • A. Dimitrios Colevas
    • 3
  • Davud Sirjani
    • 1
    Email author
  1. 1.Division of Head and Neck Surgery, Department of OtolaryngologyStanford UniversityStanfordUSA
  2. 2.Department of PathologyStanford UniversityStanfordUSA
  3. 3.Division of Oncology, Department of MedicineStanford UniversityStanfordUSA
  4. 4.Department of PediatricsStanford UniversityStanfordUSA
  5. 5.Department of RadiologyStanford UniversityStanfordUSA

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