European Archives of Oto-Rhino-Laryngology

, Volume 273, Issue 2, pp 349–354 | Cite as

Gender and modulation frequency effects on auditory steady state response (ASSR) thresholds

  • Mohd Normani Zakaria
  • Bahram Jalaei
  • Nor Alaudin Abdul Wahab
Otology

Abstract

For estimating behavioral hearing thresholds, auditory steady state response (ASSR) can be reliably evoked by stimuli at low and high modulation frequencies (MFs). In this regard, little is known regarding ASSR thresholds evoked by stimuli at different MFs in female and male participants. In fact, recent data suggest that 40-Hz ASSR is influenced by estrogen level in females. Hence, the aim of the present study was to determine the effect of gender and MF on ASSR thresholds in young adults. Twenty-eight normally hearing participants (14 males and 14 females) were enrolled in this study. For each subject, ASSR thresholds were recorded with narrow-band chirps at 500, 1,000, 2,000, and 4,000 Hz carrier frequencies (CFs) and at 40 and 90 Hz MFs. Two-way mixed ANOVA (with gender and MF as the factors) revealed no significant interaction effect between factors at all CFs (p > 0.05). The gender effect was only significant at 500 Hz CF (p < 0.05). At 500 and 1,000 Hz CFs, mean ASSR thresholds were significantly lower at 40 Hz MF than at 90 Hz MF (p < 0.05). Interestingly, at 2,000 and 4,000 Hz CFs, mean ASSR thresholds were significantly lower at 90 Hz MF than at 40 Hz MF (p < 0.05). The lower ASSR thresholds in females might be due to hormonal influence. When recording ASSR thresholds at low MF, we suggest the use of gender-specific normative data so that more valid comparisons can be made, particularly at 500 Hz CF.

Keywords

Auditory steady state response Modulation frequency Gender Chirps Estrogen 

References

  1. 1.
    Osterhammel PA, Shallop JK, Terkildsen K (1985) The effect of sleep on the auditory brainstem response (ABR) and the middle latency response (MLR). Scand Audiol 14(1):47–50PubMedCrossRefGoogle Scholar
  2. 2.
    Zirn S, Louza J, Reiman V, Wittlinger N, Hempel JM, Schuster M (2014) Comparison between ABR with click and narrow band chirp stimuli in children. Int J Pediatr Otorhinolaryngol 78(8):1352–1355PubMedCrossRefGoogle Scholar
  3. 3.
    François M, Teissier N, Barthod G, Nasra Y (2012) Sedation for children 2 to 5 years of age undergoing auditory brainstem response and auditory steady state responses recordings. Int J Audiol 51(4):282–286PubMedCrossRefGoogle Scholar
  4. 4.
    Luts H, Wouters J (2005) Comparison of MASTER and AUDERA for measurement of auditory steady-state responses. Int J Audiol 44(4):244–253PubMedCrossRefGoogle Scholar
  5. 5.
    Cebulla M, Stürzebecher E, Elberling C (2006) Objective detection of auditory steady-state responses: comparison of one-sample and q-sample tests. J Am Acad Audiol 17(2):93–103PubMedCrossRefGoogle Scholar
  6. 6.
    Naves KF, Pereira AA, Nasuto SJ, Russo IP, Andrade AO (2012) Assessment of inter-examiner agreement and variability in the manual classification of auditory brainstem response. Biomed Eng Online 11:86PubMedPubMedCentralCrossRefGoogle Scholar
  7. 7.
    D’haenens W, Dhooge I, De Vel E, Maes L, Bockstael A, Vinck BM (2007) Auditory steady-state responses to MM and exponential envelope AM(2)/FM stimuli in normal-hearing adults. Int J Audiol 46(8):399–406PubMedCrossRefGoogle Scholar
  8. 8.
    Rodrigues GR, Lewis DR (2014) Establishing auditory steady-state response thresholds to narrow band CE-chirps(®) in full-term neonates. Int J Pediatr Otorhinolaryngol 78(2):238–243PubMedCrossRefGoogle Scholar
  9. 9.
    Mühler R, Rahne T, Mentzel K, Verhey JL (2014) 40-Hz multiple auditory steady-state responses to narrow-band chirps in sedated and anaesthetized infants. Int J Pediatr Otorhinolaryngol 78(5):762–768PubMedCrossRefGoogle Scholar
  10. 10.
    Batra R, Kuwada S, Stanford TR (1989) Temporal coding of envelopes and their interaural delays in the inferior colliculus of the unanaesthetized rabbit. J Neurophysiol 61(2):257–268PubMedGoogle Scholar
  11. 11.
    Kuwada S, Anderson J, Batra R, Fitzpatrick DC, Teissier N, D’Angelo WR (2002) Sources of the scalp-recorded amplitude-modulation following response. J Am Acad Audiol 13(4):188–204PubMedGoogle Scholar
  12. 12.
    Van Maanen A, Stapells DR (2005) Comparison of multiple auditory steady-state responses (80 vs. 40 Hz) and slow cortical potentials for threshold estimation in hearing-impaired adults. Int J Audiol 44(11):613–624PubMedCrossRefGoogle Scholar
  13. 13.
    Tomlin D, Rance G, Graydon K, Tsialios I (2006) Comparison of 40 Hz auditory steady-state response (ASSR) and cortical auditory evoked potential (CAEP) thresholds in awake adult subjects. Int J Audiol 45(10):580–588PubMedCrossRefGoogle Scholar
  14. 14.
    Luts H, Desloovere C, Kumar A, Vandermeersch E, Wouters J (2004) Objective assessment of frequency-specific hearing thresholds in babies. Int J Pediatr Otorhinolaryngol 68(7):915–926PubMedCrossRefGoogle Scholar
  15. 15.
    Lee HS, Ahn JH, Chung JW, Yoon TH, Lee KS (2008) Clinical comparison of the auditory steady-state response with the click auditory brainstem response in infants. Clin Exp Otorhinolaryngol 1(4):184–188PubMedPubMedCentralCrossRefGoogle Scholar
  16. 16.
    Scherf F, Brokx J, Wuyts FL, Van de Heyning PH (2006) The ASSR: clinical application in normal-hearing and hearing-impaired infants and adults, comparison with the click-evoked ABR and pure-tone audiometry. Int J Audiol 45(5):281–286PubMedCrossRefGoogle Scholar
  17. 17.
    Lin YH, Ho CH, Wu HP (2009) Comparison of auditory steady state responses and auditory brainstem responses in audiometric assessment of adults with sensorineural hearing loss. Auris Nasus Larynx 36(2):140–145PubMedCrossRefGoogle Scholar
  18. 18.
    Dehan CP, Jerger J (1990) Analysis of gender differences in the auditory brainstem response. Laryngoscope 100(1):18–24PubMedCrossRefGoogle Scholar
  19. 19.
    McFadden D, Hsieh MD, Garcia-Sierra A, Champlin CA (2010) Differences by sex, ear, and sexual orientation in the time intervals between successive peaks in auditory evoked potentials. Hear Res 270(1–2):56–64PubMedPubMedCentralCrossRefGoogle Scholar
  20. 20.
    Vohs JL, Chambers RA, Krishnan GP, O’Donnell BF, Berg S, Morzorati SL (2010) GABAergic modulation of the 40 Hz auditory steady-state response in a rat model of schizophrenia. Int J Neuropsychopharmacol 13(4):487–497PubMedPubMedCentralCrossRefGoogle Scholar
  21. 21.
    Vohs JL, Chambers RA, O’Donnell BF, Krishnan GP, Morzorati SL (2012) Auditory steady state responses in a schizophrenia rat model probed by excitatory/inhibitory receptor manipulation. Int J Psychophysiol 86(2):136–142PubMedPubMedCentralCrossRefGoogle Scholar
  22. 22.
    Griskova-Bulanova I, Griksiene R, Korostenskaja M, Ruksenas O (2014) 40 Hz auditory steady-state response in females: when is it better to entrain? Acta Neurobiol Exp (Wars) 74(1):91–97Google Scholar
  23. 23.
    Huang GZ, Woolley CS (2012) Estradiol acutely suppresses inhibition in the hippocampus through a sex-specific endocannabinoid and mGluR dependent mechanism. Neuron 74(5):801–808PubMedPubMedCentralCrossRefGoogle Scholar
  24. 24.
    Beck RM, Ramos BF, Grasel SS, Ramos HF, Moraes MF, Almeida ER, Bento RF (2014) Comparative study between pure tone audiometry and auditory steady-state responses in normal hearing subjects. Br J Otorhinolaryngol 80(1):35–40CrossRefGoogle Scholar
  25. 25.
    Aoyagi M, Kim Y, Yokoyama J, Kiren T, Suzuki Y, Koike Y (1990) Head size as a basis of gender difference in the latency of the brainstem auditory-evoked response. Audiology 29(2):107–112PubMedCrossRefGoogle Scholar
  26. 26.
    Bowman DM, Brown DK, Kimberley BP (2000) An examination of gender differences in DPOAE phase delay measurements in normal-hearing human adults. Hear Res 142(1–2):1–11PubMedCrossRefGoogle Scholar
  27. 27.
    van der Reijden CS, Mens LM, Snik FM (2006) Frequency-specific objective audiometry: tone-evoked brainstem responses and steady-state responses to 40 Hz and 90 Hz amplitude modulated stimuli. Int J Audiol 45(1):40–45PubMedCrossRefGoogle Scholar
  28. 28.
    Herdman AT, Lins O, Van Room P, Stapells DR, Scherg M, Picton TW (2002) Intracerebral sources of human auditory steady-state responses. Brain Topogr 15(2):69–86PubMedCrossRefGoogle Scholar
  29. 29.
    Mühler R, Mentzel K, Verhey J (2012) Fast hearing-threshold estimation using multiple auditory steady-state responses with narrow-band chirps and adaptive stimulus patterns. Sci World J 2012:192178CrossRefGoogle Scholar
  30. 30.
    Cone B, Dimitrijevic A (2009) The auditory steady state response. In: Katz J, Medwetsky L, Burkhard R, Hood L (eds) Handbook of clinical audiology, 6th edn. Lippincott Williams & Wilkins, Baltimore, pp 322–350Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Mohd Normani Zakaria
    • 1
  • Bahram Jalaei
    • 1
  • Nor Alaudin Abdul Wahab
    • 2
  1. 1.Audiology Program, School of Health SciencesUniversiti Sains MalaysiaKubang KerianMalaysia
  2. 2.Audiology Program, School of Rehabilitation Sciences, Faculty of Health SciencesNational University of MalaysiaKuala LumpurMalaysia

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