Abstract
Considering the correlation between olfactory function and size of the human olfactory bulb (OB), it may be that OB volume is representative of the average number of functional olfactory receptor neurons in the nose. We observed a woman (64-year-old) with a 3-week history of hyposmia following an upper respiratory tract infection. Interestingly, both OB volumes were below the tenth percentile of the general population which seems to be difficult to explain by rapid, adaptive changes in the OB volume. It is hypothesized that small OBs may be a risk factor for acquiring olfactory loss.
References
Buschhuter D, Smitka M et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42(2):498–502
Cummings DM, Knab BR et al (1997) Effects of unilateral olfactory deprivation in the developing opossum, Monodelphis domestica. J Neurobiol 33:429–438
Gudziol V, Buschhuter D et al (2009) Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study. Brain 132(Pt 11):3096–3101
Haehner A, Rodewald A et al (2008) Changes of the volume of the human olfactory bulb with olfactory function. Arch ORL 134:621–624
Hummel T, Kobal G et al (2007) Normative data for the “Sniffin’ Sticks” including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects. Eur Arch Otorhinolaryngol 264:237–243
Korol DL, Brunjes PC (1992) Unilateral naris closure and vascular development in the rat olfactory bulb. Neuroscience 46:631–641
Leopold DA, Hornung DE et al (1991) Olfactory loss after upper respiratory infection. In: Getchell TV, Doty RL, Bartoshuk LM, Snow JB (eds) Smell and taste in health and disease. Raven Press, New York, pp 731–734
Paskin TR, Iqbal TR et al (2011) Olfactory bulb recovery following reversible deafferentation with repeated detergent application in the adult zebrafish. Neuroscience 196:276–284
Rombaux P, Duprez T et al (2009) Olfactory bulb volume in the clinical assessment of olfactory dysfunction. Rhinology 47:3–9
Seiden AM (2004) Postviral olfactory loss. Otolaryngol Clin North Am 37:1159–1166
von Gudden B (1870) Experimentaluntersuchungen ueber das periphere und zentrale Nervensystem. Archiv f Psychiatrie u Nervenkrankheiten 2:693–723
Yousem DM, Geckle RJ et al (1999) Posttraumatic smell loss: relationship of psychophysical tests and volumes of the olfactory bulbs and tracts and the temporal lobes. Acad Radiol 6:264–272
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All authors declare that they have no financial interest or benefit arising from the direct applications of their research.
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Patterson, A., Hähner, A., Kitzler, H.H. et al. Are small olfactory bulbs a risk for olfactory loss following an upper respiratory tract infection?. Eur Arch Otorhinolaryngol 272, 3593–3594 (2015). https://doi.org/10.1007/s00405-015-3524-x
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DOI: https://doi.org/10.1007/s00405-015-3524-x