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European Archives of Oto-Rhino-Laryngology

, Volume 272, Issue 8, pp 1867–1871 | Cite as

Is type 1 diabetes mellitus a cause for subtle hearing loss in pediatric patients?

  • Nader ALDajaniEmail author
  • Ahmad ALkurdi
  • Angham ALMutair
  • Abdullah ALdraiwesh
  • Khalid A. ALMazrou
Otology

Abstract

The objective of this study is to investigate the effects of IDDM on the function of the auditory pathway from the cochlea to the auditory cortex in child patients. Totally, 140 ears of 70 children with IDDM and 60 ears of 30 age and gender-matched healthy controls were included in the study. The ages of patients and controls ranged from 4 to 14 years. Audiological assessment including pure-tone audiometry, otoacoustic emission testing (OAE) and auditory brainstem response testing (ABR) has been performed to all participants. There was no significant difference between the patients and controls regarding pure-tone thresholds on audiometry (p > 0.05). The latencies of waves I, III and V on ABR were not significantly different between the patients and controls (p > 0.05). The amplitudes on DPOAE testing obtained from both groups were not significantly different at the frequencies of 2,000 and 4,000 Hz (p > 0.05). However, the DPOAE amplitudes of the patients at 1,000 Hz were significantly lower than those of controls at the same frequency (p = 0.03). There was no difference between the patients who had chronic disease (>5 years) and healthy controls regarding pure-tone audiometry, ABR and DPOAE testing results (p > 0.05). In the light of the findings obtained with pure-tone audiometry, and OAE and ABR testing, it seems that auditory system is spared in children with IDDM at clinical level. Diabetes control and chronicity of the disease do not impact on the auditory system except for a subclinical involvement in the apical portion of the cochlea.

Keywords

Type 1 diabetes mellitus IDDM Hearing loss Pediatric 

References

  1. 1.
    American Diabetes Association (2009) Diagnosis and classification of diabetes mellitus. Diabetes Care 32(Suppl 1):S62–S67PubMedCentralCrossRefGoogle Scholar
  2. 2.
    Dabelea D, Bell RA, D’Agostino RB Jr et al (2007) Incidence of diabetes in youth in the United States. JAMA 297:2716–2724PubMedCrossRefGoogle Scholar
  3. 3.
    DIAMOND Project Group (2006) Incidence and trends of childhood type 1 diabetes Worldwide 1990–1999. Diabet Med 23:857–866CrossRefGoogle Scholar
  4. 4.
    Eurodiab ACE study group (2000) Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group. Lancet 355:873–876Google Scholar
  5. 5.
    Patterson CC, Dahlquist GG, Gyurus E et al (2009) Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 373:2027–2033PubMedCrossRefGoogle Scholar
  6. 6.
    Cullen JR, Cinnamond MJ (1993) Hearing loss in diabetics. J Laryngol Otol 107(3):179–182PubMedCrossRefGoogle Scholar
  7. 7.
    Elamin A, Fadlallah M, Tuevmo T (2005) Hearing loss in children with type 1 diabetes. Indian Pediatr 42(1):15–21PubMedGoogle Scholar
  8. 8.
    Pessin AB, Martins RH, Pimenta Wde P, Simões AC, Marsiglia A, Amaral AV (2008) Auditory evaluation in patients with type 1 diabetes. Ann Otolo Rhinol Laryngol 117(5):366–370Google Scholar
  9. 9.
    Wackym PA, Linthicum FH Jr (1986) Diabetes mellitus and hearing loss: clinical and histopathologic relationship. Am J Otol 7(3):176–182PubMedGoogle Scholar
  10. 10.
    Okhovat SA, Moaddabb MH, Okhovatc SH et al (2011) Evaluation of hearing loss in juvenile insulin dependent patients with diabetes mellitus. JRMS 16(2):179–183Google Scholar
  11. 11.
    Axelsson A, Fagerberg S (1968) Auditory function in diabetics. Acta Otolaryngol 66:49–64PubMedCrossRefGoogle Scholar
  12. 12.
    Axelsson A, Sigroth K, Vertes D (1978) Hearing in diabetics. Acta Otolaryngol Suppl 356:2–21Google Scholar
  13. 13.
    Jorgensen MB (1961) The inner ear in diabetes mellitus. Arch Otolaryngol 74:373–381PubMedCrossRefGoogle Scholar
  14. 14.
    Parving A, Elberling C, Balle V et al (1990) Hearing disorders in patients with insulin-dependent diabetes mellitus. Audiology 29:113–121PubMedCrossRefGoogle Scholar
  15. 15.
    Buller N, Shvili Y, Laurian N et al (1988) Delayed brainstem auditory evoked responses in diabetic patients. J Laryngol Otol 102:857–860PubMedCrossRefGoogle Scholar
  16. 16.
    Donald MW, Bird CE, Lawson JS et al (1981) Delayed auditory brain-stem responses in diabetes mellitus. J Neurol Neurosurg Psychiatry 7:641–644CrossRefGoogle Scholar
  17. 17.
    Miller J, Beck L, Davis A et al (1983) Hearing loss in patients with diabetic retinopathy. Am J Otolaryngol 4:342–346PubMedCrossRefGoogle Scholar
  18. 18.
    Lisowska G, Namysłowski G, Morawski K, Strojek K (2001) Early identification of hearing impairment in patients with type 1 diabetes mellitus. Otol Neurotol 22:316–320PubMedCrossRefGoogle Scholar
  19. 19.
    Kakarlapudi V, Sawyer R, Staecker H (2003) The effect of diabetes on sensorineural hearing loss. Otol Neurotol 24(3):382–386PubMedCrossRefGoogle Scholar
  20. 20.
    Friedman SA, Schulman RH, Weiss S (1975) Hearing and diabetic neuropathy. Arch Intern Med 135(4):573–576PubMedCrossRefGoogle Scholar
  21. 21.
    Ferrer JP, Biurrun O, Lorente J, Conjet JI, de España R, Esmatjes E et al (1991) Auditory function in young patients with type 1 diabetes mellitus. Diabetes Res Clin Pract 11(1):17–22PubMedCrossRefGoogle Scholar
  22. 22.
    Al-Harbawi Fakhri (2011) Hearing loss in children with type 1 diabetes. Int J Pediat Otorhinolaryngol 75(Suppl 1):7CrossRefGoogle Scholar
  23. 23.
    Sieger A, White NH, Skinner MW, Spector GJ (1983) Auditory function in children with diabetes mellitus. Ann Otol Rhinol Laryngol 92(3 Pt 1):237–241PubMedCrossRefGoogle Scholar
  24. 24.
    Osterhammel D, Christau B (1980) High frequency audiometry and stapedius muscle reflex thresholds in juvenile diabetics. Scand Audiol 9(1):13–18PubMedCrossRefGoogle Scholar
  25. 25.
    Niedzielska G, Katska E (1998) ABR disturbances in children with insulin dependent diabetes mellitus. Int J Pediatr Otorhinolaryngol 44:1–4PubMedCrossRefGoogle Scholar
  26. 26.
    Fedele D, Martini A, Cardone C, Comacchio F, Bellavere F, Moli-nari G, Negrin P, Crepaldi G (1984) Impaired auditory brain-stem-evoked response in insulin-dependent diabetic subjects. Diabetes 33:1085–1089PubMedCrossRefGoogle Scholar
  27. 27.
    Khardori R, Soler NG, Good DC, Deviesc-Howard AB, Brought-on D, Walbert J (1986) Brainstem auditory and visual evoked potentials in type I (insulin-dependent) diabetic patients. Diabetologia 29:362–365PubMedCrossRefGoogle Scholar
  28. 28.
    Virtaniemi J, Laakso M, Karja J, Nuutinen J, Karjalainen S (1993) Auditory brainstem latencies in type I (insulin dependent) diabetic patients. Am J Otolaryngol 16:413–418CrossRefGoogle Scholar
  29. 29.
    Seidl R, Birnbacher R, Hauser E, Bernert G, Freilinger M, Shober E (1996) Brainstem auditory evoked potentials in young patients with IDDM. Diabetes Care 19:1220–1224PubMedCrossRefGoogle Scholar
  30. 30.
    Martini A, Comacchio F, Magnavita V (1991) Auditory brainstem and middle latency evoked responses in the clinical evaluation of diabetes. (Symposium). Diabet Med 8:874–877CrossRefGoogle Scholar
  31. 31.
    Di Leo, Di Nardo W, Cercone S, Ciervo S, Monaco ML, Greco AV, Pauldetti G, Ghirlanda G (1997) Cochlear dysfunction in IDDM patients with subclinical peripheral neuropathy. Diabetes Care 20(5):824–828PubMedCrossRefGoogle Scholar
  32. 32.
    Ottaviani F, Dozio N, Neglia CB, Ricco S, Scavini M (2002) Absence of otoacoustic emissions in insulin-dependent diabetic patients. Is there evidence for cochleopathy? J Diabet Complicat 16:338–343Google Scholar
  33. 33.
    Hilali AS, Das VK, Boulton AJM (2003) A study of otoacoustic emissions in type 1 diabetes mellitus. Audiol Med 1(4):255–260CrossRefGoogle Scholar
  34. 34.
    Lisowska G, Namyslowski G, Morawski K, Strojek K (2001) Cochlear dysfunction and diabetic microangiopathy. Scand Audiol 30(Suppl52):199–203CrossRefGoogle Scholar
  35. 35.
    Lisowska G, Namyslowski G, Morawski K, Strojek K (2001) Early identification of hearing impairment in patients with type 1 diabetes mellitus. Otol Neurol 22(3):316–320CrossRefGoogle Scholar
  36. 36.
    Di Nardo W, Ghirlanda G, Pauldetti G, Cercone S, Saponara C, Del Ninno M, Di Girolamo S, Magnani P, Di Leo M (1998) Distortion-product otoacoustic emissions and selective sensorineural loss in IDDM. Diabetes Care 21(8):1317–1321PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Nader ALDajani
    • 1
    Email author
  • Ahmad ALkurdi
    • 1
  • Angham ALMutair
    • 2
  • Abdullah ALdraiwesh
    • 1
  • Khalid A. ALMazrou
    • 1
  1. 1.Department of OtorhinolaryngologyKing Abdulaziz Medical CityRiyadhSaudi Arabia
  2. 2.Department of PediatricKing Abdulaziz Medical CityRiyadhSaudi Arabia

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