European Archives of Oto-Rhino-Laryngology

, Volume 271, Issue 5, pp 899–904 | Cite as

The controversy in the management of the N0 neck for squamous cell carcinoma of the maxillary sinus

  • Robert P. Takes
  • Alfio Ferlito
  • Carl E. Silver
  • Alessandra Rinaldo
  • Jesus E. Medina
  • K. Thomas Robbins
  • Juan P. Rodrigo
  • Marc Hamoir
  • Carlos Suárez
  • Peter Zbären
  • Vanni Mondin
  • Ashok R. Shaha
  • William M. Mendenhall
  • Primož Strojan
Review Article


Squamous cell carcinoma (SCC) of the maxillary sinus is a relatively rare disease. As the reported incidence of regional metastasis varies widely, controversy exists as to whether or not the N0 classified neck should be treated electively. In this review, the data from published series are analyzed to decide on a recommendation of elective treatment of the neck in maxillary SCC. The published series consist of heterogeneous populations of different subsites of the paranasal sinuses, different histological types, different staging and treatment modalities used and different ways of reporting the results. These factors do not allow for recommendations based on high levels of evidence. Given this fact, the relatively high incidence rate of regional metastasis at presentation or in follow-up in the untreated N0 neck, and the relatively low toxicity of elective neck irradiation, such irradiation in SCC of the maxillary sinus should be considered.


Maxillary sinus Squamous cell carcinoma Head and neck cancer Elective neck treatment 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Robert P. Takes
    • 1
  • Alfio Ferlito
    • 2
  • Carl E. Silver
    • 3
  • Alessandra Rinaldo
    • 2
  • Jesus E. Medina
    • 4
  • K. Thomas Robbins
    • 5
  • Juan P. Rodrigo
    • 6
    • 7
  • Marc Hamoir
    • 8
  • Carlos Suárez
    • 6
    • 7
  • Peter Zbären
    • 9
  • Vanni Mondin
    • 2
  • Ashok R. Shaha
    • 10
  • William M. Mendenhall
    • 11
  • Primož Strojan
    • 12
  1. 1.Department of Otolaryngology-Head and Neck SurgeryRadboud University Nijmegen Medical CenterNijmegenThe Netherlands
  2. 2.ENT ClinicUniversity of UdineUdineItaly
  3. 3.Departments of Surgery and Otolaryngology-Head and Neck Surgery, Albert Einstein College of MedicineMontefiore Medical CenterBronxUSA
  4. 4.Department of OtorhinolaryngologyThe University of Oklahoma Health Sciences CenterOklahomaUSA
  5. 5.Division of Otolaryngology-Head and Neck SurgerySouthern Illinois University School of MedicineSpringfieldUSA
  6. 6.Department of OtolaryngologyHospital Universitario Central de AsturiasOviedoSpain
  7. 7.Instituto Universitario de Oncología Del Principado de AsturiasOviedoSpain
  8. 8.Department of Head and Neck Surgery, Head and Neck Oncology ProgramSt. Luc University Hospital and Cancer CenterBrusselsBelgium
  9. 9.Department of Otorhinolaryngology-Head and Neck SurgeryUniversity HospitalBerneSwitzerland
  10. 10.Head and Neck ServiceMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  11. 11.Department of Radiation OncologyUniversity of FloridaGainesvilleUSA
  12. 12.Department of Radiation OncologyInstitute of OncologyLjubljanaSlovenia

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