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European Archives of Oto-Rhino-Laryngology

, Volume 270, Issue 9, pp 2515–2520 | Cite as

Comparison of narrow-band imaging and conventional nasopharyngoscopy for the screening of unaffected members of families with nasopharyngeal carcinoma

  • Ching-Yin HoEmail author
  • Kee-Tak Chan
  • Pen-Yuan Chu
Head and Neck

Abstract

Familial aggregation of nasopharyngeal carcinoma (NPC) has been widely reported. The excess risk is about 4–8-fold among first-degree relatives of NPC patients compared with those without a family history of the disease. We used nasopharyngoscopy and a narrow-band image system (NBI) to screen NPC high-risk patients and identify a good tool for the early detection of NPC in these high-risk groups. We recruited all available, affected blood relations of the patients. When NPC patients were more distant relatives, such as cousins, we recruited their shared second-degree relatives, such as unaffected aunts and uncles, to genetically connect the NPC cases. We performed transnasal endoscopy, first in white-light mode, then under the NBI system. There were two NBI patterns in NPC: microvascular proliferation and engorged blood vessels. The NBI pattern in normal nasopharyngeal mucosa was a regular cobblestone pattern. A prospective study included 211 asymptomatic members from 154 NPC families. We found four cases of NPC, all with a tumor stage of T1. In one patient (1/4), MRI revealed a 2-cm-diameter neck lymphadenopathy (N1). The correlation between conventional nasopharyngoscopy and NBI was very high (κ = 0.798, P = 0.000). In conclusions, NBI is not superior to conventional nasopharyngoscopy for the early detection of NPC in unaffected members of families with NPC history. The long-term follow-up is necessary in high-risk NPC patients. Further studies will be needed to determine which screening tool—conventional nasopharyngoscopy, NBI, or EB virus titer—is most effective.

Keywords

Concomitant chemoradiotherapy EB virus titer Familial aggregation Narrow-band imaging Nasopharyngeal carcinoma Nasopharyngoscope 

Notes

Acknowledgments

Funding Support by V100C-038 from Taipei Veterans General Hospital and NSC 98-2314-B-075-016-MY3.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Otolaryngology, Taipei Veterans General Hospital and School of MedicineNational Yang-Ming UniversityTaipeiTaiwan

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