European Archives of Oto-Rhino-Laryngology

, Volume 270, Issue 6, pp 1861–1865 | Cite as

Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp

  • Wenwei Hao
  • Yongping Zhu
  • Li Meng
  • Changbao Ni
  • Jing Yang
  • Huifang Zhou


The aim of this study was to investigate serum paraoxonase (PON) and arylesterase (ARE) activities, the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in the patient with nasal polyp (NP) and control group to confirm the link between oxidative stress and NP. In this prospective study, 32 patients with NP (22 males and 10 females) and 29 healthy controls (19 males and 10 females) were enrolled. Preoperative serum levels of PON, ARE, TAS, and TOS were determined, and OSI was calculated. Serum PON activity, ARE activity, and TAS tend to be decreased in patients with NP compared to healthy controls (P < 0.0001). TOS and OSI levels were significantly higher in the NP patients than in the healthy controls (P < 0.01). Furthermore, there was established positive correlation between serum PON activity and serum ARE activity in patients with NP (r = 0.454; P = 0.009). Our results support the belief that altered PON and ARE activity may be involved in the pathogenesis of NP. Increased TOS and OSI, and decreased TAS indicated that NP is the pathologic consequence of oxidative stress.


Nasal polyp Paraoxonase Arylesterase Oxidative stress 


Conflict of interest

None declared.


  1. 1.
    Pawankar R (2003) Nasal polyposis: an update: editorial review. Curr Opin Allergy Clin Immunol 3(1):1–6PubMedCrossRefGoogle Scholar
  2. 2.
    Deal RT, Kountakis SE (2004) Significance of nasal polyps in chronic rhinosinusitis: symptoms and surgical outcomes. Laryngoscope 114(11):1932–1935PubMedCrossRefGoogle Scholar
  3. 3.
    Dagli M, Eryilmaz A, Besler T, Akmansu H, Acar A, Korkmaz H (2004) Role of free radicals and antioxidants in nasal polyps. Laryngoscope 114(7):1200–1203PubMedCrossRefGoogle Scholar
  4. 4.
    Sagit M, Erdamar H, Saka C, Yalcin S, Akin I (2011) Effect of antioxidants on the clinical outcome of patients with nasal polyposis. J Laryngol Otol 125(8):811–815PubMedCrossRefGoogle Scholar
  5. 5.
    Jeanson L, Kelly M, Coste A, Guerrera IC, Fritsch J, Nguyen-Khoa T, Baudouin-Legros M, Papon JF, Zadigue P, Pruliere-Escabasse V, Amselem S, Escudier E, Edelman A (2012) Oxidative stress induces unfolding protein response and inflammation in nasal polyposis. Allergy 67(3):403–412PubMedCrossRefGoogle Scholar
  6. 6.
    Tavori H, Aviram M, Khatib S, Musa R, Nitecki S, Hoffman A, Vaya J (2009) Human carotid atherosclerotic plaque increases oxidative state of macrophages and low-density lipoproteins, whereas paraoxonase 1 (PON1) decreases such atherogenic effects. Free Radic Biol Med 46(5):607–615PubMedCrossRefGoogle Scholar
  7. 7.
    Li C, Gu Q (2009) Protective effect of paraoxonase 1 of high-density lipoprotein in type 2 diabetic patients with nephropathy. Nephrology (Carlton) 14(5):514–520CrossRefGoogle Scholar
  8. 8.
    Soran N, Altindag O, Cakir H, Celik H, Demirkol A, Aksoy N (2008) Assessment of paraoxonase activities in patients with knee osteoarthritis. Redox Rep Commun Free Radic Res 13(5):194–198CrossRefGoogle Scholar
  9. 9.
    Yildiz A, Gur M, Demirbag R, Yilmaz R, Akyol S, Aslan M, Erel O (2008) Paraoxonase and arylesterase activities in untreated dipper and non-dipper hypertensive patients. Clin Biochem 41(10–11):779–784PubMedCrossRefGoogle Scholar
  10. 10.
    Soran H, Younis NN, Charlton-Menys V, Durrington P (2009) Variation in paraoxonase-1 activity and atherosclerosis. Curr Opin Lipidol 20(4):265–274PubMedCrossRefGoogle Scholar
  11. 11.
    Rosenblat M, Aviram M (2009) Paraoxonases role in the prevention of cardiovascular diseases. BioFactors 35(1):98–104PubMedCrossRefGoogle Scholar
  12. 12.
    Rizzo M, Kotur-Stevuljevic J, Berneis K, Spinas G, Rini GB, Jelic-Ivanovic Z, Spasojevic-Kalimanovska V, Vekic J (2009) Atherogenic dyslipidemia and oxidative stress: a new look. Transl Res J Lab Clin Med 153(5):217–223CrossRefGoogle Scholar
  13. 13.
    Roberts CK, Sindhu KK (2009) Oxidative stress and metabolic syndrome. Life Sci 84(21–22):705–712PubMedCrossRefGoogle Scholar
  14. 14.
    Eckerson HW, Wyte CM, La Du BN (1983) The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet 35(6):1126–1138PubMedGoogle Scholar
  15. 15.
    Haagen L, Brock A (1992) A new automated method for phenotyping arylesterase (EC based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J Clin Chem Clin Biochem J Forum Eur Clin Chem Soc 30(7):391–395Google Scholar
  16. 16.
    Erel O (2005) A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38(12):1103–1111PubMedCrossRefGoogle Scholar
  17. 17.
    Karlidag T, Ilhan N, Kaygusuz I, Keles E, Yalcin S, Yildiz M (2005) Roles of free radicals, nitric oxide, and scavenging enzymes in nasal polyp development. Ann Otol Rhinol Laryngol 114(2):122–126PubMedGoogle Scholar
  18. 18.
    Uneri C, Ozturk O, Polat S, Yuksel M, Haklar G (2005) Determination of reactive oxygen species in nasal polyps. Rhinology 43(3):185–189PubMedGoogle Scholar
  19. 19.
    Cheng YK, Hwang GY, Lin CD, Tsai MH, Tsai SW, Chang WC (2006) Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Laryngoscope 116(3):417–422PubMedCrossRefGoogle Scholar
  20. 20.
    Cekin E, Ipcioglu OM, Erkul BE, Kapucu B, Ozcan O, Cincik H, Gungor A (2009) The association of oxidative stress and nasal polyposis. J Int Med Res 37(2):325–330PubMedGoogle Scholar
  21. 21.
    Bugdayci G, Kaymakci M, Mackness MI (2008) Nitrite/nitrate and malondialdehyde levels in nasal polyp. Cell Mol Biol (Noisy-le-grand) 54(Suppl:OL):1043–1045Google Scholar
  22. 22.
    Durrington PN, Mackness B, Mackness MI (2001) Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol 21(4):473–480PubMedCrossRefGoogle Scholar
  23. 23.
    Watson AD, Berliner JA, Hama SY, La Du BN, Faull KF, Fogelman AM, Navab M (1995) Protective effect of high density lipoprotein associated paraoxonase. Inhibition of the biological activity of minimally oxidized low density lipoprotein. J Clin Investig 96(6):2882–2891PubMedCrossRefGoogle Scholar
  24. 24.
    Camps J, Garcia-Heredia A, Rull A, Alonso-Villaverde C, Aragones G, Beltran-Debon R, Rodriguez-Gallego E, Joven J (2012) PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways. PPAR Res 2012:616371PubMedCrossRefGoogle Scholar
  25. 25.
    Ramadan R, Tawdy A, Abdel Hay R, Rashed L, Tawfik D (2012) The Antioxidant Role of Paraoxonase 1 and Vitamin E in Three Autoimmune Diseases. Skin Pharmacol Physiol 26(1):2–7PubMedCrossRefGoogle Scholar
  26. 26.
    Karaman E, Uzun H, Papila I, Balci H, Ozdilek A, Genc H, Yanardag H, Papila C (2010) Serum paraoxonase activity and oxidative DNA damage in patients with laryngeal squamous cell carcinoma. J Craniofac Surg 21(6):1745–1749PubMedCrossRefGoogle Scholar
  27. 27.
    Karakucuk S, Baskol G, Oner AO, Baskol M, Mirza E, Ustdal M (2004) Serum paraoxonase activity is decreased in the active stage of Behcet’s disease. Br J Ophthalmol 88(10):1256–1258PubMedCrossRefGoogle Scholar
  28. 28.
    Cakmak A, Zeyrek D, Atas A, Celik H, Aksoy N, Erel O (2009) Serum prolidase activity and oxidative status in patients with bronchial asthma. J Clin Lab Anal 23(2):132–138PubMedCrossRefGoogle Scholar
  29. 29.
    Ercan S, Cakmak A, Kosecik M, Erel O (2009) The oxidative state of children with cyanotic and acyanotic congenital heart disease. Anatol J Cardiol 9(6):486–490Google Scholar
  30. 30.
    Bowler RP, Crapo JD (2002) Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol 110(3):349–356PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Wenwei Hao
    • 1
  • Yongping Zhu
    • 2
  • Li Meng
    • 1
  • Changbao Ni
    • 1
  • Jing Yang
    • 1
  • Huifang Zhou
    • 1
  1. 1.Department of OtolaryngologyTianjin Medical University General HospitalTianjinPeople’s Republic of China
  2. 2.Department of AnesthesiologyTianjin Medical University Eye CenterTianjinPeople’s Republic of China

Personalised recommendations