European Archives of Oto-Rhino-Laryngology

, Volume 270, Issue 5, pp 1581–1592 | Cite as

Prognostic biological features in neck dissection specimens

  • Julia A. Woolgar
  • Asterios Triantafyllou
  • James S. LewisJr.
  • Jennifer Hunt
  • Michelle D. Williams
  • Robert P. Takes
  • Lester D. R. Thompson
  • Pieter J. Slootweg
  • Kenneth O. Devaney
  • Alfio Ferlito
Review Article


The superior prognostic value offered by routine histopathological staging of neck dissections, as compared to clinical staging using palpation and modern imaging techniques, is well established in the literature concerning the management of squamous cell carcinoma of the head and neck. In this review, we discuss the definitions and criteria used in standardised routine histopathological reporting and explore additional potential nodal prognostic features. In addition, we critically appraise the value of immunohistochemistry, histochemistry, molecular and other non-morphological techniques and suggest tumour and host features that merit further investigations.


Head and neck cancer Histopathology Metastasis Molecular analysis Prognosis 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Julia A. Woolgar
    • 1
  • Asterios Triantafyllou
    • 1
  • James S. LewisJr.
    • 2
  • Jennifer Hunt
    • 3
  • Michelle D. Williams
    • 4
  • Robert P. Takes
    • 5
  • Lester D. R. Thompson
    • 6
  • Pieter J. Slootweg
    • 7
  • Kenneth O. Devaney
    • 8
  • Alfio Ferlito
    • 9
  1. 1.Oral Pathology, School of Dentistry and Dental HospitalUniversity of LiverpoolLiverpoolUK
  2. 2.Department of Pathology and ImmunologyWashington University School of MedicineMissouriUSA
  3. 3.Department of Pathology and Laboratory Services, College of MedicineUniversity of Arkansas for Medical SciencesArkansasUSA
  4. 4.Department of PathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA
  5. 5.Department of Otolaryngology-Head and Neck SurgeryRadboud University Nijmegen Medical CentreNijmegenThe Netherlands
  6. 6.Department of PathologyWoodland Hills Medical CenterWoodland HillsUSA
  7. 7.Department of PathologyRadboud University Nijmegen Medical CentreNijmegenThe Netherlands
  8. 8.Department of PathologyAllegiance HealthJacksonUSA
  9. 9.ENT ClinicUniversity of Udine School of MedicineUdineItaly

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