European Archives of Oto-Rhino-Laryngology

, Volume 269, Issue 9, pp 2065–2067 | Cite as

The effects of CPAP treatment on nasal mucosa in patients with obstructive sleep apnea

  • Cem Saka
  • Erkan VuralkanEmail author
  • İbrahim Hikmet Fırat
  • Sibel Alicura
  • Sema Hücümenoğlu
  • İstemihan Akın
  • Sadık Ardıç
  • Ayhan Gökler


The aim of the study was to demonstrate the effects of nasal CPAP treatment on the morphology and function of nasal mucosa in patients with obstructive sleep apnea (OSA). Patients with complaints relevant to OSA underwent respiratory function tests, arterial blood gas analyses and polysomnography. Saccharine test and nasal biopsies were performed to assess the mucociliary transport time and to observe the histopathological changes in patients with apnea–hypopnea index ≥15 in whole night polysomnography. Tissue samples were obtained from middle and inferior turbinates and septal mucosa to observe the degree of inflammation and fibrosis by semiquantitative means. Biopsies and mucociliary transport test were performed before and 3 months after the initiation of CPAP treatment. A total of 25 patients with a mean age of 52 were enrolled in the study. While the pretreatment mucociliary transport time before and 3 months after the treatment were 10.50 and 11.50 min respectively. The difference between these values was statistically insignificant. Mean apnea–hypopnea index was 63.19, while mean partial oxygen pressure was 75.46 mmHg. Nasal CPAP treatment was introduced with a mean pressure of 9.54 cmH2O. The degree of inflammation and fibrosis was found to be significantly increased after CPAP treatment. Nasal CPAP leads to alterations in mucosa. Efforts should be directed to make CPAP treatment a safer method via protecting the morphologic and functional properties of the nasal mucosa.


Obstructive sleep apnea nCPAP Nasal Mucosa Mucociliary transport Fibrosis Inflammation 


Conflict of interest

There are no conflicts of interest related to this manuscript.


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Cem Saka
    • 1
  • Erkan Vuralkan
    • 2
    • 5
    Email author
  • İbrahim Hikmet Fırat
    • 3
  • Sibel Alicura
    • 1
  • Sema Hücümenoğlu
    • 4
  • İstemihan Akın
    • 1
  • Sadık Ardıç
    • 3
  • Ayhan Gökler
    • 1
  1. 1.1st Department of ENTMinistry of Health Dışkapı Yıldırım Beyazıt Training and Research HospitalAnkaraTurkey
  2. 2.Department of ENTMinistry of Health Trabzon Numune Training and Research HospitalTrabzonTurkey
  3. 3.Department of Chest DiseasesMinistry of Health Dışkapı Yıldırım Beyazıt Training and Research HospitalAnkaraTurkey
  4. 4.2nd Department of PathologyMinistry of Health Dışkapı Yıldırım Beyazıt Training and Research HospitalAnkaraTurkey
  5. 5.Department of Otorhinolaryngology ClinicTrabzon Numune Training and Research HospitalTrabzonTurkey

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