European Archives of Oto-Rhino-Laryngology

, Volume 268, Issue 8, pp 1201–1204 | Cite as

Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract

  • Markus GugatschkaEmail author
  • Karl Kiesler
  • Barbara Obermayer-Pietsch
  • Andrea Groselj-Strele
  • Antonia Griesbacher
  • Gerhard Friedrich
Head and Neck


Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.


Vitamin D status 25-Hydroxyvitamin D (25(OH)D) Head and neck squamous cell carcinoma (HNSCC) 


Conflict of interest



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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Markus Gugatschka
    • 1
    Email author
  • Karl Kiesler
    • 1
  • Barbara Obermayer-Pietsch
    • 2
  • Andrea Groselj-Strele
    • 3
  • Antonia Griesbacher
    • 3
  • Gerhard Friedrich
    • 1
  1. 1.Department of PhoniatricsENT University Hospital Graz, Medical University GrazGrazAustria
  2. 2.Division of Endocrinology and Nuclear Medicine, Department of Internal MedicineMedical University GrazGrazAustria
  3. 3.Unit of Biostatistics, Center for Medical ResearchMedical UniversityGrazAustria

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