European Archives of Oto-Rhino-Laryngology

, Volume 268, Issue 7, pp 1035–1040 | Cite as

Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature

  • Yen-Ling Kuo
  • Tzong-Yang Tu
  • Chia-Fan Chang
  • Wing-Yin Li
  • Shyue-Yih Chang
  • An-Suey Shiao
  • Pen-Yuan Chu
  • Kee-Tak Chan
  • Shyh-Kuan Tai
  • Yi-Fen Wang
  • Shu-Ching Kao
  • Shou-Yen Kao
  • Wen-Liang Lo
  • Cheng-Hsien Wu
  • Wen-Hu Shu
  • Shu Ma
  • Tien-Hsiang Wang
Head and Neck

Abstract

Pleomorphic adenomas, or benign mixed tumors, make up 65% of all salivary gland tumors. They also can be found as solid tumors in other parts of the head and neck region, such as the auditory canal, the eyelids, and the orbital area. In this study, we investigated extra-major salivary gland pleomorphic adenomas of the head and neck region retrospectively at a tertiary care center. Between March 1998 and June 2009, 37 patients underwent primary surgery for extra-major salivary gland pleomorphic adenoma of the head and neck. The duration of symptoms, radiographic findings, operative procedures, and pathologic findings were documented. Of the 37 patients enrolled, 22 were male and 15 were female, with a median age of 57 years. Tumors were found in the soft palate, hard palate, nasopharynx, orbital area, trachea, buccal mucosa, cheek, nasal septum, upper lip, lower eyelid, and external auditory canal. Cellular variant of the pleomorphic adenoma was found in four patients, while the remaining patients presented with the classic variant. No myxoid subgroup was noted in our study. Carcinoma ex pleomorphic adenoma was observed only in one patient for whom radical surgery was performed. Twenty-eight patients (76%) had long-term follow-ups, with the average follow-up period being 4.5 years. Local recurrence was observed in three patients, and they underwent revision surgery during the follow-up period. Our results indicate that extra-major salivary gland pleomorphic adenomas are most commonly found in the soft palate. Wide excision was the treatment of choice, although its efficacy might be compromised with cosmetics and functional structures of the head and neck. Therefore, long-term follow-up of patients is necessary.

Keywords

Pleomorphic adenoma Extra-major salivary gland tumor Salivary neoplasm Minor salivary glands 

Notes

Acknowledgment

The project was supported by Taipei Veterans General Hospital research grants. No. V98C1-176 and V99C1-196 to T.-Y. Tu.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Yen-Ling Kuo
    • 1
  • Tzong-Yang Tu
    • 1
  • Chia-Fan Chang
    • 1
  • Wing-Yin Li
    • 2
  • Shyue-Yih Chang
    • 1
  • An-Suey Shiao
    • 1
  • Pen-Yuan Chu
    • 1
  • Kee-Tak Chan
    • 1
  • Shyh-Kuan Tai
    • 1
  • Yi-Fen Wang
    • 1
  • Shu-Ching Kao
    • 3
  • Shou-Yen Kao
    • 4
  • Wen-Liang Lo
    • 4
  • Cheng-Hsien Wu
    • 4
  • Wen-Hu Shu
    • 5
  • Shu Ma
    • 6
  • Tien-Hsiang Wang
    • 6
  1. 1.Department of OtolaryngologyTaipei Veterans General Hospital and National Yang Ming University School of MedicineTaipeiTaiwan
  2. 2.Department of PathologyTaipei Veterans General Hospital and National Yang Ming University School of MedicineTaipeiTaiwan
  3. 3.Department of OphthalmologyTaipei Veterans General Hospital and National Yang Ming University School of MedicineTaipeiTaiwan
  4. 4.Department of StomatologyTaipei Veterans General Hospital and National Yang Ming University School of MedicineTaipeiTaiwan
  5. 5.Department of Chest SurgeryTaipei Veterans General Hospital and National Yang Ming University School of MedicineTaipeiTaiwan
  6. 6.Department of Plastic SurgeryTaipei Veterans General Hospital and National Yang Ming University School of MedicineTaipeiTaiwan

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