European Archives of Oto-Rhino-Laryngology

, Volume 268, Issue 3, pp 393–399

Endonasal phototherapy significantly alleviates symptoms of allergic rhinitis, but has a limited impact on the nasal mucosal immune cells


DOI: 10.1007/s00405-010-1375-z

Cite this article as:
Brehmer, D. & Schön, M.P. Eur Arch Otorhinolaryngol (2011) 268: 393. doi:10.1007/s00405-010-1375-z


The literature documents the fact that UV irradiation of cutaneous Langerhans cells (LC) in vivo prevents the development of contact allergy and produces long-lasting immunosuppression. However, not much is known about the effect of UV irradiation on the LC of the nasal mucosa and their connection with clinical scores. Local antigen presentation may be necessary for both primary and recall T cell responses to birch pollen in patients with hay fever. Endonasal phototherapy combination of UVB (5%), UVA (25%) and visible light (70%) utilises the immunosuppressive effects of UV irradiation. The aim of this study was to correlate clinical symptom scores with possible changes in the LC of the nasal mucosa induced by UV radiation. The clinical effectiveness of this form of treatment is discussed. Nasal biopsies were obtained from ten birch pollen-sensitive patients with seasonal rhinitis before and after endonasal phototherapy. All patients showed a significant clinical benefit post-treatment as assessed by standardised instruments, including total nasal symptom score, nasal congestion score, nasal itching score, sneezing score, nasal secretion score and impairment-to-health score. However, we found no significant morphological changes, to, or quantitative differences in, the CD1a+, CD4, CD8 or CD31 cells before and 14 days after treatment. Despite the positive clinical effect, the study revealed no effect of UV irradiation on the LC and other analysed cells of the nasal mucosa immune system. Possible reasons for this are discussed.


UV radiation Endonasal phototherapy Nasal Langerhans cells CD1a Allergic rhinitis 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Private ENT Clinic Goettingen, Faculty of MedicineUniversity Witten/HerdeckeGöttingenGermany
  2. 2.Department of Dermatology, Venereology and AllergologyGeorg August UniversityGöttingenGermany

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