European Archives of Oto-Rhino-Laryngology

, Volume 268, Issue 2, pp 273–279 | Cite as

Delayed wound infection after supracricoid partial laryngectomy following failure of high dose radiation

  • Meijin Nakayama
  • Makito Okamoto
  • Yutomo Seino
  • Shunsuke Miyamoto
  • Takashi Matsuki
  • Akiko Ogawa
Head and Neck
First Online:
Received:
Accepted:

Abstract

Past radiation therapy is known as a major risk factor promoting post-supracricoid partial laryngectomy (SCPL) complications. Risk of post-SCPL complications may further increase following failure of high dose radiation; in these patients, wound infection may become evident more than 1 month after an uneventful post-surgical course. By defining this complication as “Delayed Wound Infection” and reviewing the clinical features, we intended to elucidate the mechanism, risk factors, and management of this post-SCPL complication. Between 1997 and 2009, 60 patients received SCPL. The incidence of post-SCPL wound infection was analyzed in reflect to radiation status, radiation dose, and medical histories. Of 60 patients, delayed wound infection was identified in 4 (7%); radiation doses were 65, 68, 70, and 76.8 Gy (avg. 70 Gy). Blood data including white blood cell and C-reactive protein showed slight elevation before the delayed infection became evident. Patients with high dose radiation (≥65 Gy) accompanied by histories of diabetes and renal insufficiency are considered a high risk group. Delayed re-epithelialization of the inner surface of the cricohyoido gap was presumed to be the main pathogenesis. Early initiation of antibiotics and hyperbaric oxygen therapy are effective for rapid recovery. “Delayed Wound Infection” was treatable and patients undergoing surgery after failure of high dose radiation should be managed with extra precaution, but should not be excluded from the indications for SCPL.

Keywords

Laryngeal cancer Infection Complications Radiation failure 
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Notes

Acknowledgments

This study was supported by a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (#.20592028: 2008-2011).

Conflict of interest

The authors declare that there are no conflicts of interest in this study.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Meijin Nakayama
    • 1
  • Makito Okamoto
    • 1
  • Yutomo Seino
    • 1
  • Shunsuke Miyamoto
    • 1
  • Takashi Matsuki
    • 1
  • Akiko Ogawa
    • 1
  1. 1.Department of OtorhinolaryngologyKitasato University School of MedicineSagamiharaJapan

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