European Archives of Oto-Rhino-Laryngology

, Volume 267, Issue 11, pp 1735–1742 | Cite as

Transoral CO2 laser microsurgery for Tis-T3 supraglottic squamous cell carcinomas

  • Giorgio PerettiEmail author
  • Cesare Piazza
  • Mohssen Ansarin
  • Luigi De Benedetto
  • Daniela Cocco
  • Augusto Cattaneo
  • Piero Nicolai
  • Fausto Chiesa


Eighty patients affected by supraglottic cancer were treated by transoral carbon dioxide laser surgery between 1989 and 2006 in two Italian institutions. Patient staging was as follows: 2 pTis, 20 pT1, 38 pT2, and 20 pT3. Simultaneous or 1-month delayed neck dissection (ND) was performed on 27 (34%) patients, unilaterally in 10 and bilaterally in 17. The pN category was as follows: 9 pN0, 6 pN1, 8 pN2b, and 4 pN2c. A total of 16 (20%) patients received complementary radiotherapy (RT) and 5 (6%) were subjected to chemo-RT for persistent tumor after re-excision due to positive margins, multiple lymph nodes, and/or extracapsular spread after ND. The last follow-up was in December 2008. The 5-year overall, disease-specific and disease-free survivals, local control with laser alone, and organ preservation rates calculated by Kaplan–Meier analysis were 84.4, 97.4, 88.3, 96, and 97.2%, respectively. Univariate analysis showed a statistically significant impact on disease-free survival, local control with laser alone, and organ preservation of pT category (p = 0.009, p = 0.01, and p = 0.03, respectively), while pN category and tumor stage negatively influenced disease-free survival (p = 0.007 and p = 0.01, respectively). This series confirms the good overall oncologic outcomes obtained by transoral laser surgery for Tis, T1, T2, and selected T3 supraglottic cancer with minimal pre-epiglottic space involvement.


Transoral laser surgery Carbon dioxide laser Laryngeal cancer Supraglottic cancer Conservative laryngeal surgery 


Conflict of interest statement

The authors have no conflict of interest.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Giorgio Peretti
    • 1
    Email author
  • Cesare Piazza
    • 1
  • Mohssen Ansarin
    • 2
  • Luigi De Benedetto
    • 1
  • Daniela Cocco
    • 1
  • Augusto Cattaneo
    • 2
  • Piero Nicolai
    • 1
  • Fausto Chiesa
    • 2
  1. 1.Department of Otorhinolaryngology, Head and Neck SurgeryUniversity of BresciaBresciaItaly
  2. 2.Department of Head and Neck SurgeryEuropean Institute of OncologyMilanItaly

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