European Archives of Oto-Rhino-Laryngology

, Volume 267, Issue 9, pp 1327–1335 | Cite as

Allergic rhinitis caused by food allergies

  • Cemal Cingi
  • Duygu Demirbas
  • Murat Songu
Review Article


Food allergies occur in 1–2% of adults and in 8% of children under 6 years of age. Food-induced allergies are immunological reactions that cause a variety of symptoms affecting the skin, gastrointestinal tract, and respiratory tract. The reactions are mediated by both IgE- and non-IgE-dependent (cellular) mechanisms. Isolated food-induced allergic rhinitis is not common as it frequently occurs together with other food allergy symptoms such as asthma, eczema, oral allergic manifestations, urticaria, and gastrointestinal symptoms. The present paper provides an overview of food allergies and food-induced allergic rhinitis.


Food allergy Allergic rhinitis IgE mediated Peanut allergy Urticaria Anaphylaxis 


Conflict of interest statement

The authors declare no competing interests.


  1. 1.
    Johansson SG, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF (2004) Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 113(5):832–836CrossRefPubMedGoogle Scholar
  2. 2.
    Arshad SH, Holgate ST, Adkinson NF, Babu KS (2006) Allergy: an atlas of investigation and management. Atlas Medical Publishing Ltd., pp 125–135Google Scholar
  3. 3.
    Sicherer SH, Sampson HA (2009) Food allergy: recent advances in pathophysiology and treatment. Annu Rev Med 60:261–277CrossRefPubMedGoogle Scholar
  4. 4.
    Nowak-Wegrzyn A, Sampson HA (2006) Adverse reactions to foods. Med Clin North Am 90:97–127CrossRefPubMedGoogle Scholar
  5. 5.
    Cianferoni A, Spergel J (2009) Food allergy: review, classification and diagnosis. Allergology International 58Google Scholar
  6. 6.
    Mahmoudi M (2008) Allergy and asthma. Practical diagnosis and management. Lange. Mc Graw-Hill Companies, Inc., pp 215–222Google Scholar
  7. 7.
    Sampson HA (2004) Update on food allergy. J Allergy Clin Immunol 113:805–819CrossRefPubMedGoogle Scholar
  8. 8.
    Saarinen KM, Pelkonen AS, Makela MJ, Savilahti E (2005) Clinical course and prognosis of cow’s milk allergy are dependent on milk-specific IgE status. J Allergy Clin Immunol 116:869–875CrossRefPubMedGoogle Scholar
  9. 9.
    Eriksson NE, Moller C, Werner S, Magnusson J, Bengtsson U, Zolubas M (2004) Self-reported food hypersensitivity in Sweden, Denmark, Estonia, Lithuania, and Russia. J Investig Allergol Clin Immunol 14:70–79PubMedGoogle Scholar
  10. 10.
    Sicherer SH, Munoz-Furlong A, Sampson HA (2004) Prevalence of seafood allergy in the United States determined by a random telephone survey. J Allergy Clin Immunol 114:159–165CrossRefPubMedGoogle Scholar
  11. 11.
    Sicherer SH, Sampson HA (2006) Food allergy. J Allergy Clin Immunol 117:S470–S475CrossRefPubMedGoogle Scholar
  12. 12.
    Sicherer SH, Munoz-Furlong A, Sampson HA (2003) Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol 112:1203–1207CrossRefPubMedGoogle Scholar
  13. 13.
    Bock SA, Munoz-Furlong A, Sampson HA (2001) Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 107:191–193CrossRefPubMedGoogle Scholar
  14. 14.
    Lee LA, Burks AW (2006) Food allergies: prevalence, molecular characterization, and treatment/prevention strategies. Annu Rev Nutr 26:539–565CrossRefPubMedGoogle Scholar
  15. 15.
    Sampson HA, Broadbent KR, Bernhisel-Broadbent J (1989) Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity. N Engl J Med 321:228–232PubMedCrossRefGoogle Scholar
  16. 16.
    Dahan S, Roth-Walter F, Arnaboldi P, Agarwal S, Mayer L (2007) Epithelia: lymphocyte interactions in the gut. Immunol Rev 215:243–253CrossRefPubMedGoogle Scholar
  17. 17.
    Sampson HA (1999) Food allergy. Part 1: Immunopathogenesis and clinical disorders. J Allergy Clin Immunol 103:717–728CrossRefPubMedGoogle Scholar
  18. 18.
    Mayer L (2003) Mucosal immunity. Pediatrics 11:1595–1600Google Scholar
  19. 19.
    Mayer L (2000) Mucosal immunity and gastrointestinal antigen processing. J Pediatr Gastroenterol Nutr 30(Suppl):S4–S12CrossRefPubMedGoogle Scholar
  20. 20.
    Breiteneder H, Mills EN (2005) Molecular properties of food allergens. J Allergy Clin Immunol 115:14–23CrossRefPubMedGoogle Scholar
  21. 21.
    Lack G, Fox D, Northstone K, Golding J (2003) Factors associated with the development of peanut allergy in childhood. N Engl J Med 348:977–985CrossRefPubMedGoogle Scholar
  22. 22.
    Eigenmann PA, Sicherer SH, Borkowski TA, Cohen BA, Sampson HA (1998) Prevalence of IgE-mediated food allergy among children with atopic dermatitis. Pediatrics 101(3):E8CrossRefPubMedGoogle Scholar
  23. 23.
    Breiteneder H, Ebner C (2000) Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 106:27–36CrossRefPubMedGoogle Scholar
  24. 24.
    Liacouras CA, Markowitz JE (1999) Eosinophilic esophagitis: a subset of eosinophilic gastroenteritis. Curr Gastroenterol Rep 1:253–258CrossRefPubMedGoogle Scholar
  25. 25.
    Rothenberg ME (2004) Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol 113:11–28CrossRefPubMedGoogle Scholar
  26. 26.
    Beyer K, Castro R, Birnbaum A, Benkov K, Pittman N, Sampson HA (2002) Human milk-specific mucosal lymphocytes of the gastrointestinal tract display a TH2 cytokine profile. J Allergy Clin Immunol 109:707–713CrossRefPubMedGoogle Scholar
  27. 27.
    Nowak-Wegrzyn A, Sampson HA, Wood RA, Sicherer SH (2003) Food protein-induced enterocolitis syndrome caused by solid food proteins. Pediatrics 111:829–835CrossRefPubMedGoogle Scholar
  28. 28.
    Malik V, Ghosh S, Woolford TJ (2007) Rhinitis due to food allergies: fact or fiction? J Laryngol Otol 121:526–529CrossRefPubMedGoogle Scholar
  29. 29.
    Tariq SM, Matthews SM, Hakin EA, Arshad SH (2000) Egg allergy in infancy predicts respiratory allergic disease by 4 years of age. Paediatr Allergy Immunol 11:162–167CrossRefGoogle Scholar
  30. 30.
    James JM, Bernhisel-Broadbent J, Sampson HA (1994) Respiratory reactions provoked by double-blind food challenges in children. Am J Respir Crit Care Med 149:59–64PubMedGoogle Scholar
  31. 31.
    Palosuo K, Varjonen E, Nurkkala J, Kalkkinen N, Harvima R, Reunala T et al (2003) Transglutaminase-mediated cross-linking of a peptic fraction of omega-5 gliadin enhances IgE reactivity in wheat-dependent, exercise-induced anaphylaxis. J Allergy Clin Immunol 111:1386–1392CrossRefPubMedGoogle Scholar
  32. 32.
    Sampson HA (1999) Food allergy. Part 2: Diagnosis and management. J Allergy Clin Immunol 103:981–999CrossRefPubMedGoogle Scholar
  33. 33.
    Bock S, Buckley J, Holst A, May C (1978) Proper use of skin tests with food extracts in diagnosis of food hypersensitivity. Clin Allergy 8:559–564CrossRefPubMedGoogle Scholar
  34. 34.
    Sampson HA (2001) Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 107:891–896CrossRefPubMedGoogle Scholar
  35. 35.
    Heine RG, Verstege A, Mehl A, Staden U, Rolinck-Werninghaus C, Niggemann B (2006) Proposal for a standardized interpretation of the atopy patch test in children with atopic dermatitis and suspected food allergy. Pediatr Allergy Immunol 17:213–217PubMedGoogle Scholar
  36. 36.
    Sampson HA (2003) Anaphylaxis and emergency treatment. Pediatrics 111(Suppl):1601–1608PubMedGoogle Scholar
  37. 37.
    Vadas P, Perelman B (2003) Activated charcoal forms non-IgE binding complexes with peanut proteins. J Allergy Clin Immunol 112:175–179CrossRefPubMedGoogle Scholar
  38. 38.
    Van Dellen R, Lewis J (1994) Oral administration of cromolyn in a patient with protein losing enteropathy, food allergy, and eosinophilic gastroenteritis. Mayo Clin Proc 69:441–444PubMedGoogle Scholar
  39. 39.
    Li XM, Zhang TF, Huang CK, Srivastava K, Teper AA, Zhang L et al (2001) Food Allergy Herbal Formula-1 (FAHF-1) blocks peanut-induced anaphylaxis in a murine model. J Allergy Clin Immunol 108:639–646CrossRefPubMedGoogle Scholar
  40. 40.
    Leung DYM, Sampson HA, Yunginger JW, Burks AW, Schneider L, Wortel CH et al (2003) Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 348:986–993CrossRefPubMedGoogle Scholar
  41. 41.
    Shin D, Compadre CM, Sampson HA, Huang SK, Maleki Si Kooper RA et al (1998) Identification and analysis of the critical amino acids and structures necessary for specific IgE binding Ara h 1, a major peanut allergen. J Biol Chem 273:13759CrossRefGoogle Scholar
  42. 42.
    Li XM, Srivastava K, Grishin A, Huang SK, Schofield BH, Burks AW et al (2003) Persistent protective effect oh heat-killed Escherichia coli producing “engineered” recombinant peanut proteins in a murine model of peanut allergy. J Allergy Clin Immunol 112:159–167CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of Otorhinolaryngology, Medical FacultyOsmangazi UniversityEskisehirTurkey
  2. 2.Department of OtorhinolaryngologyAcibadem HospitalsIstanbulTurkey
  3. 3.Department of OtorhinolaryngologyDr. Behçet Uz Children’s HospitalIzmirTurkey
  4. 4.Department of OtorhinolaryngologyIzmir Ataturk Research and Training HospitalIzmirTurkey

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