European Archives of Oto-Rhino-Laryngology

, Volume 267, Issue 11, pp 1793–1799 | Cite as

Heterotopic gastric mucosal patch of the esophagus is associated with higher prevalence of laryngopharyngeal reflux symptoms

  • Vui Heng ChongEmail author
  • Anand Jalihal


Laryngopharyngeal reflux (LPR) is common in clinical practice. Heterotopic gastric mucosal patch of the proximal esophagus (HGMP) is reported to cause LPR symptoms. This study assessed the prevalence of LPR symptoms and correlation with the size of HGMP. Four hundred and sixty-two patients undergoing endoscopy were carefully questioned regarding LPR symptoms experienced in the previous 12 weeks. The size of the HGMP was assessed and documented during endoscopy. Clinicopathological classifications were assigned (types I–V) accordingly. HGMP [median one patch (range 1–3), median size 15 mm [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35] was detected in 26 (19 HGM type I and 7 HGM type II] patients giving a prevalence of 5.6%. Among the indications, there were significantly more LPR symptoms as referral indications among patients with HGMP. There were no significant differences in the endoscopic findings. On specific enquiries, significantly more HGMP patients had experienced any LPR symptoms (73.1 vs. 25.9%, p < 0.001) specifically chronic cough (p = 0.002), throat discomfort/hoarseness (p < 0.001), globus sensation (p = 0.004), regurgitation (p < 0.001). HGMP patients also had more heartburn (p = 0.001). Larger HGMP (≥15 mm) was only associated with more chronic cough (p = 0.022). In conclusion, patients with HGMP have significantly more LPR symptoms. However, most were mild and detected through specific enquiries. Interestingly, the size of HGMP did not significantly affect the prevalence of LPR symptoms.


Cervical inlet patch Heartburn Heterotopic gastric mucosal patch Globus Inlet patch Regurgitation 



We would like to acknowledge the assistants provided by the endoscopy staff during duration of the study. We would also like to acknowledge the assistant of Ms Lim Ai Giok for grammar check.

Conflict of interest statement



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Gastroenterology Unit, Department of MedicineRaja Isteri Pengiran Anak Saleha (RIPAS) HospitalBandar Seri BegawanBrunei Darussalam

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