European Archives of Oto-Rhino-Laryngology

, Volume 267, Issue 8, pp 1285–1290 | Cite as

Surgical anatomy of the floor of the oral cavity and the cervical spaces as a rationale for trans-oral, minimal-invasive endoscopic surgical procedures: results of anatomical studies

  • Thomas Wilhelm
  • Joris J. Harlaar
  • Anton Kerver
  • Gert-Jan Kleinrensink
  • Tahar Benhidjeb
Head and Neck

Abstract

Over the past 10 years, several minimally invasive procedures for thyroid surgery have been developed. Because of extensive dissection in the thoracic and neck region, the name “minimal-invasive” is misleading. The aim of this study was to define a new trans-oral access to the cervical spaces especially to the thyroid on the basis of natural orifice surgery. Three embalmed human specimens were dissected for complete review of the anatomical situation in the cervical region. In additional five fresh frozen human specimens after an experimental trans-oral endoscopic minimally invasive thyroidectomy the anatomical structures of the floor of the oral cavity as well as the anterior neck region were evaluated. It was possible to create a working space under the platysma muscle with respect to the surgical planes of the neck and fascial layers. Within this area, the pretracheal region can be reached and the thyroid gland can be visualized and resected. To access the working space, a trocar for endoscopic view is placed medially in the floor of the oral cavity sublingually. The trocar passes the muscles of the floor of the oral cavity easily without relation to relevant anatomical structures. A first exclusively sublingual approach had to be abandoned because triangulation of the instruments could not be reached. Therefore, the approach was modified by positioning the working trocars in the oral vestibule bilaterally. By this way, a road map for accessing all anterior cervical regions directly under the platysma muscle could be established and anatomical landmarks and areas of possible collateral damage could have been defined. This combined sublingual and bi-vestibular trans-oral endoscopic approach enables an easy access to all structures and spaces of the anterior neck region with respect to anatomical preformed layers neck, even to the thyroid as one of the more distant structures.

Keywords

Endoscopic Minimal invasive Thyroidectomy Cadaver study Anatomy Floor of the oral cavity 

Introduction

One of the first attempts to reduce surgical access trauma in thyroidectomy was the unilateral, endoscopic thyroidectomy performed by Hüscher et al. [1] on the 8 July 1996. As minimally invasive procedures in thyroid surgery evolved over the past 10 years the so-called minimally invasive video-assisted thyroidectomy [2] has so far become most widespread. This was mainly established by the working groups of Micolli and Ruggieri from Italy [3, 4, 5]. Endoscopic minimally invasive approaches were also established experimentally and clinically for parathyroidectomies by different groups [6, 7, 8]. With respect to thyroid pathologies, techniques were developed to avoid scars in the neck region: such approaches are the chest [9], the axillary [10] and the combined axillary bilateral breast approach [11]. However, these techniques do not comply with the term “minimally invasive” and they are associated with an extensive dissection of the skin and subcutaneous layers of the chest and neck region and therefore being rather maximally invasive.

Latest attempts in minimizing surgical trauma lead to an experimental trans-oral access to the thyroid gland using a single-port access via an axilloscope [12]; this approach have so far not overcome the first experimental state and is in fact a hybrid approach, because additional 3.5-mm skin incisions 15 mm below the level of the larynx were necessary.

Trans-oral resections of the submandibular gland date back to the early sixties of the last century. Downton and Qvist described the trans-oral resection of the submandibular gland by open surgery via the floor of the oral cavity [13]. Other endoscopic surgical procedures were also performed to treat fractures of the mandible, but they were still limited to the narrow spaces surrounding the oral cavity.

The border of the per-oral region to gain access to the cervical spaces by a trans-oral, natural orifice approach was never used successfully before. Therefore, our vision was to develop an endoscopic, minimal-invasive approach for thyroidectomy.

The aim of our study was to define anatomical spaces, surgical planes and related neural and vascular structures to create a safe and reproducible trans-oral access and pathway to the cervical spaces especially to the more distant thyroid gland. This access should guide an easy and safe way to preformed anatomical spaces between different fascial layers of the neck. In these “sliding” layers, a preparation without any bleeding should be possible and neural structures can be spared. The space to be reached is the sub-platysmal layer above the pretracheal strap muscles. Here, the linea alba colli can easily be identified, transsected and the thyroid gland visualized, mobilized and resected. For minimally invasive thyroid resection the principal access to this working space was executed with standard instruments with a diameter of 2.7 and 3.5 mm used in general abdominal surgery for minimally invasive procedures.

Materials and methods

This anatomical study was carried out between 28 January 2008 and 14 May 2008 at the Department of Neuroscience and Anatomy of the Erasmus MC, University Medical Centre Rotterdam (The Netherlands). In total, eight human specimens (5 males, 3 females) with a mean age of 81 years were used for this dissection study.

Three embalmed human specimens were dissected for complete anatomical information of the cervical region. In additional five fresh frozen human specimens after an experimental trans-oral endoscopic minimally invasive thyroidectomy, the anatomical structures and pathways were evaluated.

Anatomical dissections were performed, based on surgical planes: first the skin, subcutaneous tissue and platysma muscle were removed. Beyond the superficial fascia, the vessel architecture and the nerves of the anterior triangle of the neck were separated from the connective tissues and lymph nodes. Then, the different surgical spaces in the submandibular grove were demonstrated and the way through the floor of the oral cavity to the sublingual space was shown.

In the three embalmed human specimen, the vascular system and neural structures of the frontal and lateral neck region were dissected to define landmarks for a pathway through the floor of the oral cavity. After this, we developed the trans-oral access to the pretracheal space in five fresh frozen human cadavers. To qualitatively determine damage to anatomically relevant structures, all five specimens were dissected after performing the surgical procedure.

All relevant steps of the dissections were documented by a digital SLR camera (Canon EOS 400D), image processing was performed with Adobe Photoshop CS4 Extended Version©.

Results

Our hypothesis was that a working space under the platysma muscle in the anterior neck region (level VI) can be created with respect to the surgical planes and fascial layers of the neck and without significant damage to anatomical structures, such as vessels and nerves. Within this area, it should be possible to reach the vessels and lymph nodes under the sternocleidomastoid muscle as well as the pretracheal region. In this compartment, the thyroid can be visualized and resected.

To access the working space by a trans-oral manner in a first attempt, a trocar for optical information with a 3-mm Hopkins endoscope (Karl Storz GmbH, Tuttlingen, Germany) was placed in the midline between and before the papillae of Wharton’s duct. The endoscope passed the muscles of the floor of the oral cavity easily without damage to relevant anatomical structures. The muscles of the floor of the oral cavity are separated bilaterally in the midline. No vessels or nerves are present in this area, and hence, there are no structures at risk (Fig. 1).
Fig. 1

Muscles of the floor of the oral cavity and relevant neural and vascular structures. Blue circle indicating entry point for the median sublingual trocar, ECA external carotid artery

The submandibular triangle

To get access for our 3-mm working trocars, we passed the floor of the oral cavity sublingually on both sides through the submandibular triangle. The submandibular triangle can be divided into two compartments: the sublingual and the submandibular space. In the sublingual spatium, it was possible to localize the duct of the submandibular gland, the sublingual glands and the lingual nerve as well as the sublingual artery and vein (Fig. 2). The submandibular space includes the gland, the hypoglossal nerve, the facial artery and parts of the lingual nerve. The two spaces are partially divided by the mylohyoid muscle. The complete submandibular triangle is covered with a shield of the superficial cervical fascia, originating from the premandibular subplatysmal plane, enveloping the gland totally and running to its attachment at the posterior belly of the digastric muscle. This results in a “bag”, carrying the sublingual and the submandibular gland (Fig. 3).
Fig. 2

Muscles of the floor of the oral cavity: blue circle indicating pass through of the optical trocar, optical trocar in the midline and working trocar on the left side in place (MHM mylohyoid muscle, SHM sternohyoid muscle, DM-AB anterior belly of the digastric muscle, GHM geniohyoid muscle, ICA internal carotid artery, ECA external carotid artery, RMV retromandibular vein, HGN hypoglossal nerve, SMG submandibular gland—lift up)

Fig. 3

“Submandibular bag”: part of the superficial fascia covering the submandibular spatium, the submandibular gland and relevant vascular and neural structures (left side submandibular gland removed)

Superficial to the submandibular gland, the facial vein crosses the superficial fascia to reach the anterior border of the mandible. The facial artery enters the triangle under the posterior belly of the digastric and stylohyoid muscle; it ascends to emerge above or through the upper border of the gland (Fig. 2). The marginal mandibular branch of the facial nerve courses through the triangle under the platysma muscle and under the superficial fascia but outside the submandibular “bag”. It courses over the facial vessels as it travels upward to supply the peri-oral muscles.

The hypoglossal nerve enters the triangle deep to the posterior belly of the digastric muscle. It lies on the surface of the hypoglossus muscle and courses deep to the mylohyoid muscle to supply motor function to the tongue. The lingual nerve, a branch of the mandibular nerve, is found under the border of the mandible on the hypoglossus muscle superficial to the hypoglossal nerve. It is attached to the submandibular gland by the submandibular ganglion and courses deep to the mylohyoid muscle to provide sensation to the anterior tongue and floor of the oral cavity (Fig. 2).

Finally, when passing the sublingual gland and the Wharton’s duct medially and proceeding forward to the submandibular gland (Fig. 4), it is possible to reach the submandibular triangle safely. In this region, we have to carefully avoid damage to the lingual and hypoglossal nerve and leave the submandibular “bag” to reach the working space through the mylohyoid muscle. Relevant vascular and nervous structures are passed rectangular to get a maximum safety.
Fig. 4

Cranial view of a dissection of the sublingual lateral area (1 sublingual spatium, 2 submandibular spatium)

Exclusively sublingual versus sublingual bi-vestibular access

A major disadvantage of this access was the minimal triangulation of the working instruments witch only reaches 5.8°. Therefore, either special instruments with bendable tips have to be developed or a modified approach has to be established (Fig. 5a).
Fig. 5

Possible triangulation of instruments in different endoscopic approaches: a exclusively sublingual approach, b sublingual bi-vestibular approach

Consequently, we changed our trans-oral exclusively sublingual approach to a combined bi-vestibular and sublingual access. The optical access port is also placed in the midline sublingually, but the working trocars are moved to the vestibule of oral cavity bilaterally beneath the incisive teeth of the mandible (Fig. 6). Through a 5-mm incision in the mucosa of the vestibule we can reach the periosteum of the mandible directly and pass under the platysma muscle and the superficial fascia to get access to the infrahyoidal working space. By entering the plane under the superficial fascia it was possible to avoid damage to the marginal branch of the facial nerve as well as damage to the facial vein (Fig. 7). The only structure at risk is the mental nerve. Blunt submucosal dissection helps in securing intact function of the nerve after surgery (Fig. 8). In all, anatomical dissections after the trans-oral combined bi-vestibular and sublingual access procedure, all relevant structures where intact: all muscles of the floor of the oral cavity as well as all vessels and nerves are intact. The triangulation of the instruments reached acceptable 20°–30° (Fig. 5b).
Fig. 6

Sublingual bi-vestibular endoscopic approach: the two working and the midline optic trocars are in place under the platysma muscle without carbon dioxide insufflation

Fig. 7

Position of the lateral working trocar (*) placed in the oral vestibule—no relevant structures are under risk

Fig. 8

Vestibular access on the left side: under the mucosa the mental nerve can be easily identified and spared

With this method, we performed the first successful endoscopic thyroidectomy utilizing a tree-point exclusively trans-oral access on the 14 May 2008.

Discussion

The concept of natural orifice surgery (NOS) is based on the principle of reaching the pathology to be treated by passing through natural entries of the human body (oral cavity, vagina, anus or urethra). This should minimize access trauma, spare working time and therefore be gentler than standard surgical procedures. NOS principles in patient’s procedures were followed in resections of tumors of the rectum and in endoscopic transvaginal appendectomies as well as cholecystectomies [14, 15, 16, 17, 18]. Natural orifice translumenal endoscopic surgery utilizes also a natural orifice as the access point but is limited to truly endoscopic procedures: these techniques were established by Kalloo and his team in 2000 [19, 20] and meanwhile different surgical procedures have been performed by this technique [14, 15].

Regarding neck surgery endoscopic approaches have been tested experimentally especially in the harvesting of sentinel nodes in the recent years [21, 22, 23] as well as for endoscopic submandibular gland resection [24, 25, 26]. All those techniques as well as the minimally invasive approaches for thyroidectomy are no real NOS procedures because they always depend on skin incisions to reach the working area by endoscopic view and instruments.

The trans-oral endoscopic approach developed in this anatomical study is a feasible access to the anterior neck region (level VI): the thyroid gland as well as the central lymph node stations surrounding the trachea could be reached, a working space can be created by the insufflation of carbon dioxide and a dissection of the relevant structures is possible by endoscopic instruments. The major vessels of the neck (common carotid artery, internal jugular vein) and neural structures (recurrent laryngeal nerve and vagus nerve) can be visualized. The technique itself is limited to the anterior neck as an approach to the lateral lymph node stations (levels II–IV) requires a passing of these major vascular structures. This issue must be addressed in further anatomical proof-of-concept studies.

In the anatomical dissection studies, we could show that a direct subplatysmal access through the oral cavity passes no regions of risk, especially vessels and nerves. The only structure under risk is the mental nerve (third branch of the trigeminal nerve) when the vestibular working trocars are brought in place: this nerve usually is located directly under the submucosa of the oral vestibule and can be identified easily. Therefore, dissection and preservation should be practicable.

Regarding a possible clinical application in a first step, there should be some limitations:
  • no history of previous neck surgery in the field of action;

  • the targeted specimen volume should not extend 30 ml and

  • singular nodules should not exceed 20 mm in diameter to allow a harvesting of the resected specimen.

Principle limitations are associated with the use of an endoscopic technique itself: bleeding and suboptimal view are typical problems of endoscopic surgeries and might perhaps complicate a clinical application for thyroid surgery.

A study on feasibility and safety in an animal experiment with short time survival will address and clarify these questions.

Nevertheless, the presented endoscopic minimally invasive approach uses an exclusively trans-oral approach and therefore meets the criteria of NOS. Major advantages of the technique in our view are time-saving access respecting the anatomically given surgical planes which probably avoid postoperative scar formation and swallowing disorders. Not at least it is a minimally invasive procedure without any visible scars.

Therefore, in conclusion by this way a minimally invasive approach for thyroidectomy could have been established in anatomical studies. The intimate knowledge of the anatomical structures of the floor of the oral cavity and a dissection according to surgical planes enables a trans-oral access to all structures and spaces of the anterior region of the neck. As has been proven in this study, even the thyroid gland as one of the more distant structures can be reached.

Notes

Acknowledgments

The project was supported by Karl Storz GmbH, Tuttlingen, Germany and the New European Surgical Academy (NESA), Berlin, Germany.

Conflict of interest statement

There is no financial relationship with the organizations that sponsored the research. The authors declare that there is no conflict of interest.

References

  1. 1.
    Hüscher CS, Chiodini S, Napolitano G, Recher A (1997) Endoscopic right thyroid lobectomy. Surg Endosc 11:877–878CrossRefPubMedGoogle Scholar
  2. 2.
    Miccoli P, Berti P, Coute M, Bendinelli C, Marcocci C (1999) Minimally invasive surgery for thyroid small nodules: preliminary report. J Endocrinol Invest 22:849–851PubMedGoogle Scholar
  3. 3.
    Miccoli P, Berti P, Frustaci GL, Ambrosiani CE, Materazzi G (2006) Video-assisted thyroidectomy: indications and results. Langenbecks Arch Surg 391(2):68–71CrossRefPubMedGoogle Scholar
  4. 4.
    Miccoli P, Berti P, Raffaelli M, Materazzi G, Baldacci S, Rossi G (2001) Comparison between minimally invasive video-assisted thyroidectomy and conventional thyroidectomy: a prospective randomized study. Surgery 130(6):1039–1043CrossRefPubMedGoogle Scholar
  5. 5.
    Ruggieri M, Straniero A, Genderini M, D’Armiento M, Fumarola A, Trimboli P, Gargiulo P (2007) The eligibility of MIVA approach in thyroid surgery. Langenbecks Arch Surg 392:413–416CrossRefPubMedGoogle Scholar
  6. 6.
    Gagner M (1996) Endoscopic subtotal parathyroidectomy in patients with primary hyperparathyroidism. Br J Surg 83:875CrossRefPubMedGoogle Scholar
  7. 7.
    Brunt LM, Jones DB, Wu JS, Quasebarth MA, Meininger T, Soper NJ (1997) Experimental development of an endoscopic approach to neck exploration and parathyroidectomy. Surgery 122:893–901CrossRefPubMedGoogle Scholar
  8. 8.
    Naitoh T, Gagner M, Garcia-Ruiz A, Heniford BT (1998) Endoscopic endocrine surgery in the neck. An initial report of endoscopic subtotal parathyroidectomy. Surg Endosc 12:202–205CrossRefPubMedGoogle Scholar
  9. 9.
    Yeung GH (1998) Endoscopic surgery of the neck: a new frontier. Surg Laparosc Endosc 8:227–232CrossRefPubMedGoogle Scholar
  10. 10.
    Ikeda Y, Takami H, Sasaki Y, Kan S, Niimi M (2000) Endoscopic neck surgery by the axillary approach. J Am Coll Surg 191:336–340CrossRefPubMedGoogle Scholar
  11. 11.
    Ohgami M, Ishii S, Arisawa Y, Ohmori T, Noga K, Furukawa T, Kitajima M (2000) Scarless endoscopic thyroidectomy: breast approach for better cosmesis. Surg Laparosc Endosc Percutan Tech 10:1–4PubMedGoogle Scholar
  12. 12.
    Witzel K, von Rahden BH, Kaminski C, Stein HJ (2008) Transoral access for endoscopic thyroid resection. Surg Endosc 22(8):1871–1875CrossRefPubMedGoogle Scholar
  13. 13.
    Downton D, Qvist G (1960) Intra-oral excision of the submandibular gland. Proc R Soc Med 53:543–544PubMedGoogle Scholar
  14. 14.
    Bernhardt J, Gerber B, Schober H-C, Kähler G, Ludwig K (2008) NOTES—case report of a unidirectional flexible appendectomy. Int J Colorectal Dis 23:547–550CrossRefPubMedGoogle Scholar
  15. 15.
    Hochberger J, Menke D, Matthes K, Lamadé W, Köhler P (2009) Transluminale Interventionen (“NOTES”)–aktueller Stand. Dtsch Med Wochenschr 134:467–472CrossRefPubMedGoogle Scholar
  16. 16.
    Hogan S, Cullen JP, Talamini MA, Mintz Y, Ferreres A, Jacobsen GR, Sandler B, Bosia J, Savides T, Easter DW, Savu MK, Ramamoorthy SL, Whitcomb E, Agarwal S, Lukacz E, Dominguez G, Ferraina P (2009) Natural orifice surgery: initial clinical experience. Surg Endosc 23:1512–1518CrossRefGoogle Scholar
  17. 17.
    Sodergren MH, Clark J, Athanasou T, Teare J, Yang G-Z, Darzi A (2009) Natural orifice translumenal endoscopic surgery: critical appraisal of applications in clinical practice. Surg Endosc 23:680–687CrossRefPubMedGoogle Scholar
  18. 18.
    Palanivelu C, Rajan PS, Rangarajan M, Parthasarathi R, Senthilnathan P, Prasad M (2008) Transvaginal endoscopic appendectomy in humans: a unique approach to NOTES-world’s first report. Surg Endosc 22:1343–1347CrossRefPubMedGoogle Scholar
  19. 19.
    Kalloo AN, Kantsevoy SV, Singh VK et al (2000) Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity. Gastroenterology 118:A1039CrossRefGoogle Scholar
  20. 20.
    Kalloo AN, Singh VK, Jagannath SB, Niiyama H, Hill SL, Vaughn CA, Magee CA, Kantsevoy SV (2004) Flexible transgastric peritoneoscopy: a novel approach to diagnostic and therapeutic interventions in the peritoneal cavity. Gastrointest Endosc 60:114–117CrossRefPubMedGoogle Scholar
  21. 21.
    Werner JA, Sapundzhiev NR, Teymoortash A, Dunne AA, Behr T, Folz BJ (2004) Endoscopic sentinel lymphadenectomy as a new diagnostic approach in the N0 neck. Eur Arch Otorhinolaryngol Head Neck 261:463–468Google Scholar
  22. 22.
    Malloy KM, Cognetti DM, Wildemore BM, Cunnane MF, Keane WM, Pribitkin EA, Rosen D (2007) Feasibility of endoscopic sentinel node biopsy in the porcine neck. Otolaryngol Head Neck Surg 136:806–810CrossRefPubMedGoogle Scholar
  23. 23.
    Sesterhenn AM, Folz BJ, Werner JA (2008) Surgical technique of endoscopic sentinel lymphadenectomy in the N0 neck. Oper Techn Otolaryngol 19:26–32CrossRefGoogle Scholar
  24. 24.
    Terris DJ, Haus BM, Gourin CG (2004) Endoscopic neck surgery: resection of the submandibular gland in a cadaver model. Laryngoscope 114:407–410CrossRefPubMedGoogle Scholar
  25. 25.
    Guyot L, Duroure F, Richard O, Lebeau J, Passagia J-G, Raphael B (2005) Submandibular gland endoscopic resection: a cadaveric study. Int J Oral Maxillofac Surg 34:407–410CrossRefPubMedGoogle Scholar
  26. 26.
    Kessler P, Bloch-Birkholz A, Birkholz T, Neukam FW (2006) Feasibility of an endoscopic approach to the submandibular neck region: experimental and clinical results. Brit J Oral Maxillofac Surg 44:103–106CrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Thomas Wilhelm
    • 1
  • Joris J. Harlaar
    • 2
  • Anton Kerver
    • 2
  • Gert-Jan Kleinrensink
    • 2
  • Tahar Benhidjeb
    • 3
  1. 1.Department Otolaryngology, Head, Neck and Facial Plastic SurgeryHELIOS Kliniken Leipziger LandBornaGermany
  2. 2.Department of Neuroscience-Anatomy, Erasmus MCUniversity Medical Centre RotterdamRotterdamThe Netherlands
  3. 3.Department of General, Visceral, Vascular and Thoracic SurgeryCharité-Universitätsmedizin BerlinBerlinGermany

Personalised recommendations