European Archives of Oto-Rhino-Laryngology

, Volume 267, Issue 6, pp 845–849

Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature

  • Aldona W. Woźniak
  • Marian Tomasz Nowaczyk
  • Krzysztof Osmola
  • Wojciech Golusinski
Review Article

Abstract

Benign osteoblastoma is a rarely seen tumor of the facial bones. The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus. The histopathological diagnosis was one of osteoblastoma. Postoperative recurrence with soft tissue infiltration suggested an osteosarcoma radiologically, but the histological examination again revealed the presence of an osteoblastoma. A second recurrence occured in the pharyngo-glossal region and this time the tumor was histologically diagnosed as an osteoblastoma, but with foci of well-differentiated osteosarcoma. The patient was given a course of radiotherapy, but clinical and radiological examination 8 months later revealed lung metastases and chemotherapy was started. Unfortunately, the patient died months later. While osteoblastomas are rare, and their sarcomatous change even rarer, our experience with this case lead us to suggest that a therapeutic preventative approach, involving both chemotherapy and total excision of the tumor, is the regime to adopt with osteoblastomas which involve soft tissues and have radiological features suggesting malignancy.

Keywords

Osteoblastoma Osteosarcoma Malignant transformation Mandibular bone 

References

  1. 1.
    Lucas DR, Unni KK, Mc Leod RA, O’Connor MI, Sim FH (1994) Osteoblastoma clinicopathologic study of 306 cases. Hum Pathol 25:117–134CrossRefPubMedGoogle Scholar
  2. 2.
    Ueno H, Ariji E, Tanaka T, Kanada S, Mori S, Goto M et al (1994) Imaging features of maxillary osteoblastoma and its malignant transformation. Skeletal Radiol 23:509–512CrossRefPubMedGoogle Scholar
  3. 3.
    Agrawala R, Graham RJ, Panella JS (1996) CT and MRI of aggressive osteoblastoma of thyroid cartilage. J Comput Assist Tomogr 20:116–118CrossRefGoogle Scholar
  4. 4.
    Kunze E, Enderle A, Radig K, Schneider-Stock R (1996) Aggressive osteoblastoma with focal malignant transformation and development of pulmonary metastases: a case report with a review of literature. Gen Diagn Pathol 141:377–392PubMedGoogle Scholar
  5. 5.
    Figueiredo EG, Vellutini E, Velasco O, Siqueira M, Bougar P (1998) Giant osteoblastoma of temporal bone: case report. Arq Neuropsiquiatr 56:292–295PubMedGoogle Scholar
  6. 6.
    Cervoni L, Innocenzi G, Raguso M, Salvati M, Caruso R (1997) Osteoblastoma of the calvaria: report of two cases diagnosed with MRI and clinical review. Neurosurg Rev 20:51–54CrossRefPubMedGoogle Scholar
  7. 7.
    Ohkawa M, Fujiwara N, Tanabe M, Takashima H, Satoh K, Mori Y et al (1997) Benign osteoblastoma of the temporal bone. Am J Neuroradiol 18:324–326PubMedGoogle Scholar
  8. 8.
    Velegrakis G, Prokopakis E, Papadakis C, Karampekios S, Koutsoubi K, Helidonis E (1997) Osteoblastoma of the nasal cavity arising from the perpendicular plate of the ethmoid bone. J Laryngol Otol 111:865–868CrossRefPubMedGoogle Scholar
  9. 9.
    Snow RD, Christianson MD, Dowling EA, Brogdon BG (1994) Case report: left supraorbital osteoblastoma. Skeletal Radiol 23:656–659CrossRefPubMedGoogle Scholar
  10. 10.
    Cerase A, Priolo F (1998) Skeletal benign bone-forming lesions. Eur J Radiol 27(Suppl 1):891–897Google Scholar
  11. 11.
    Mehdian H, Faraj AA, Weatherley C (1998) Painful scoliosis secondary to osteoblastoma of the vertebral body. Eur Spine J 7:246–248CrossRefPubMedGoogle Scholar
  12. 12.
    Mori Y, Takayasu M, Saito K, Seki Y, Shibuya M, Yoshida J (1998) Benign osteoblastoma of the odontoid process of the axis: a case report. Surg Neurol 49:274–277CrossRefPubMedGoogle Scholar
  13. 13.
    Weber C, Maas R (1996) Osteoblastoma simulating osteosarcoma of the petrous bone. Aktuelle Radiol 6:338–340PubMedGoogle Scholar
  14. 14.
    Figarella-Branger D, Perez-Castillo M, Garbe L (1991) Malignant transformation of an osteoblastoma of the skull, an exceptional occurrence: case report. J Neurosurg 75:138–142CrossRefPubMedGoogle Scholar
  15. 15.
    Grace J, McCarthy S, Stankovic R, Marsden W (1993) Malignant transformation of osteoblastoma study using image analysis microdensitometry. J Clin Pathol 46:1024–1029CrossRefPubMedGoogle Scholar
  16. 16.
    Ataoglu O, Oygur T, Yamalik K, Yucel E (1994) Recurrent osteoblastoma of the mandible: a case report. J Oral Maxillofac Surg 52:86–90CrossRefPubMedGoogle Scholar
  17. 17.
    Berberoglu S, Oguz A, Aribal E, Ataoglu O (1997) Osteoblastoma response to radiotherapy and chemotherapy. Med Pediatr Oncol 28:305–309PubMedGoogle Scholar
  18. 18.
    Schaser KI, Bail HJ, Haas NP, Melcher I (2002) Treatment concepts of benign bone tumors and tumor-like bone lesions. Chirurg 73:1181–1190CrossRefPubMedGoogle Scholar
  19. 19.
    Bertoni F, Unni KK, Dahlin DC (1985) Osteosarcoma resembling osteoblastoma. Cancer 55:416–426CrossRefPubMedGoogle Scholar
  20. 20.
    Cheung FM, Wu WC, Lam CK, Fu YK (1997) Diagnostic criteria for pseudomalignant osteoblastoma. Histopathology 31:196–200CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Aldona W. Woźniak
    • 1
  • Marian Tomasz Nowaczyk
    • 2
  • Krzysztof Osmola
    • 2
  • Wojciech Golusinski
    • 3
  1. 1.Department of Clinical PathomorphologyPoznań University of Medical SciencesPoznanPoland
  2. 2.Department of Maxillo-Facial SurgeryPoznań University of Medical SciencesPoznanPoland
  3. 3.Department of Head and Neck Surgery and Laryngological Oncology, Great Poland Cancer CenterPoznan University of Medical SciencesPoznanPoland

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