Cholesterol granuloma in thyroglossal cysts: a clinicopathological study
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Thyroglossal duct cyst (TDC) is a congenital anomaly caused by retention of epithelial remnants from the descent of the thyroid gland during embryological development. Cholesterol granuloma represents a granulomatous reaction to precipitates of cholesterol crystals in tissue, usually related to middle-ear disease. The association of TDC with cholesterol granuloma has hardly been reported. This study describes five patients with TDC and cholesterol granuloma over a 16-year-period. The treatment consisted of excision of the TDC and the mid-portion of the hyoid bone and excision of a core of tissue between the hyoid bone and the foramen cecum (Sistrunk procedure). We speculate that the pathogenesis of cholesterol granuloma in TDC resembles that in the paranasal sinuses, as both sites provide a closed, poorly ventilated hollow structure with slow drainage. Our five patients accounted for 13% of all patients with TDC treated in our center during the same period, indicating that cholesterol granuloma in TDC may not be as rare as previously thought.
KeywordsThyroglossal duct cyst Cholesterol granuloma Hemorrhage
Conflict of interest statement
The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.
- 5.Hellquist HB (1990) Pathology of the nose and paranasal sinuses. Butterworth Ltd, Oxford, pp 74–76Google Scholar
- 17.Sistrunk WE (1928) Technique of removal of cysts and sinuses of the thyroglossal duct. Surg Gynecol Obstet 46:109–112Google Scholar
- 24.Barnes L (1997) The ear. In: Silverberg SG, DeLellis RA, Frable WJ (eds) Priciples and practice of surgical pathology and cytopatholegy, 3rd edn. Churchill Livingstone, New York, pp 2839–2841Google Scholar