Nasopharyngeal carcinoma: our experience
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The objectives of our study were to characterize nasopharyngeal carcinoma patients in the Portuguese Institute of Oncology Hospital in Lisbon (IPOLFG) and identify the main factors that interfere with patients survival rate. We performed a retrospective study involving 157 patients (65% male and 35% female) between the years 2000 and 2005, and a histological classification according to Health World Organization. We constructed a Kaplan–Meier survival curve for the studied patients and evaluated the significance of the different studied factors with a Pearson correlation study. With an average age of 53 years, most of the carcinomas were type III (58%), followed by type II (30%) and at last type I (8%). Fifty-one of carcinomas were in stage IV at time of diagnosis. Ninety-five patients (60%) had remission. Five-year actuarial survival rate of all patients was 65.1%. There was a significant difference (P = 0.033) in the actuarial survival rate of staged IV patients treated with adjuvant chemotherapy. Undifferentiated nasopharyngeal carcinoma is the most frequent type in our geographic area. Chemotherapy improves survival rate, mainly in late stages.
KeywordsNasopharyngeal carcinoma Survival Lisbon Chemotherapy
My deepest gratitude to my friend and great mathematician Lucian Rhadu, for his precious help in the statistical study. Also to Pedro Miguel Viana Baptista and to Pedro Miguel Lourenço for their advices in revision this work.
- 1.Boussen H, Bouaoina N, Gamoudi A, Moukni N et al (2007) Cancers du nasopharynx. In: Encyclopédie Médico-Chirurgicale. 2007, 20-590-A-10Google Scholar
- 4.Nichols J, Agathanggelou A, Fung K, Xiangguo Z et al (1997) The association of squamous cell carcinomas of the nasopharynx with Epstein–Barr virus shows geographical variation reminiscent of Burkitt’s lymphoma. J Pathol 183(2):164–168. doi:10.1002/(SICI)1096-9896(199710)183:2<164::AID-PATH919>3.0.CO;2-JCrossRefGoogle Scholar
- 6.Punwaney R, Brandwein M, Zhang D, Urken M et al (1999) Human papillomavirus may be common within nasopharyngeal carcinoma of Caucasian Americans: investigation of Epstein–Barr virus and human papillomavirus in Eastern and Western nasopharyngeal carcinoma using ligation-dependent polymerase chain reaction. Head Neck 21(1):21–29. doi:10.1002/(SICI)1097-0347(199901)21:1<21::AID-HED3>3.0.CO;2-ZPubMedCrossRefGoogle Scholar
- 11.Klemenc P, Marin J, Soba E, Gale N et al (2006) Distribution of Epstein–Barr virus genotypes in throat washings, sera, peripheral blood lymphocytes and in EBV positive tumor biopsies from Slovenian patients with nasopharyngeal carcinoma. J Med Virol 78(8):1083–1090. doi:10.1002/jmv.20666 PubMedCrossRefGoogle Scholar
- 13.Pai P, Tseng C, Chuang C, Wei K et al (2007) Polymorphism of C-terminal activation region 2 of Epstein–Barr virus latent membrane protein 1 in predicting distant failure and post-metastatic survival in patients with nasopharyngeal carcinoma. Head Neck 29(2):109–119. doi:10.1002/hed.20483 PubMedCrossRefGoogle Scholar