European Archives of Oto-Rhino-Laryngology

, Volume 264, Issue 9, pp 1113–1116 | Cite as

Negative pressure pulmonary edema: report of three cases and review of the literature

  • Yuan-Chieh Chuang
  • Chih-Hung Wang
  • Yaoh-Shiang LinEmail author
Case Report


Pulmonary edema following the relief of an upper airway obstruction is an uncommon and unpredictable clinical entity. This unusual disease is actually attributed to pulmonary and hemodynamic changes engendered by high negative intrathoracic pressures during the state of obstructed respiration, such as laryngospasm, epiglottitis, laryngotracheal neoplasm, etc. In this article, we report three cases of negative pressure pulmonary edema (NPPE) developed after the operations of tracheotomy, adenoidectomy, and microlaryngeal surgery. The etiology, pathophysiology, diagnosis, management, and outcome of NPPE are also brought into further discussion.


Upper airway obstruction Negative intrathoracic pressure Pulmonary edema 


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Yuan-Chieh Chuang
    • 1
  • Chih-Hung Wang
    • 1
  • Yaoh-Shiang Lin
    • 1
    Email author
  1. 1.Department of Otolaryngology, Head and Neck SurgeryTri-Service General Hospital, National Defense Medical CenterTaipeiTaiwan, Republic of China

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