European Archives of Oto-Rhino-Laryngology

, Volume 264, Issue 4, pp 395–399

Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis

Rhinology

DOI: 10.1007/s00405-006-0204-x

Cite this article as:
Kim, J.J., Min, J.Y. & Lee, J.H. Eur Arch Otorhinolaryngol (2007) 264: 395. doi:10.1007/s00405-006-0204-x

Abstract

The IL-4 receptor (IL-4R) and IL-13 genes are candidate genes in atopic diseases. The IL-4Rα chain and IL-13 promoter polymorphisms are gain-of-function mutations associated with atopy. We tested whether polymorphisms in the IL-4Rα chain and the coding region of the IL-13 gene are associated with allergic rhinitis in a Korean population. Polymerase chain reaction-based assays for IL-4Rα Gln551Arg and IL-13 exon 4 G2044A were used for genotyping. There were no differences in the frequencies of the genotypes and alleles of IL-4Rα between the controls and patients. The frequency of the IL-13 exon 4 2044A allele was statistically different between the controls and patients. Our results suggest that the IL-13 exon 4 G2044A polymorphism confers susceptibility to the development of allergic rhinitis in Koreans, whereas the IL-4Rα Gln551Arg polymorphism is not related to allergic rhinitis.

Keywords

IL-4 receptor alpha IL-13 Allergic rhinitis Polymorphism 

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Jeong Joong Kim
    • 1
  • Jung Youl Min
    • 1
  • Jae Hoon Lee
    • 2
  1. 1.Department of Anatomy, Wonkwang Institute of Medical ScienceWonkwang University School of MedicineIksanSouth Korea
  2. 2.Department of Otolaryngology, Wonkwang Institute of Medical ScienceWonkwang University School of MedicineIksanSouth Korea

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