Influence of anatomy and head position on intranasal drug deposition
- 261 Downloads
The objective of this study was to determine the influence of individual anatomical differences on intranasal drug deposition. The data of a comparison of seven different administration techniques in ten healthy volunteers was used in this single-blind crossover pilot study. After intranasal administration of a dyed test formulation, endoscopic video imaging was done on seven non-sequential days. The deposition pattern per individual around the head of the middle turbinate was analyzed for each technique and correlated with the individual anatomy. Decreased deposition of dyed test formulation in the target area around the head of the middle turbinate was observed in the presence of minor septal deviations, narrow nasal valve areas, or inferior turbinate hypertrophy; a lateral head position helps to bypass a minor septal deviation. Although results are preliminary, we conclude that anatomy and head position are important factors in the deposition of topical nasal drugs and may be the key to improving individual local nasal (steroid) treatment.
KeywordsNasal drug delivery Nasal polyposis Rhinosinusitis Anatomy Distribution Head position
We wish to thank Valois (France) for their support with the single-unit dose device.
- 6.Fokkens WJ, Lund V, Bachert C, Clement P, Helllings P, Holmstrom M, Jones N, Kalogjera L, Kennedy D, Kowalski M, Malmberg H, Mullol J, Passali D, Stammberger H, Stierna P (2005) EAACI position paper on rhinosinusitis and nasal polyps executive summary. Allergy 60(5):583–601PubMedCrossRefGoogle Scholar
- 13.Mackay I (1997) Infective rhinitis and sinusitis. In: Scott Browne, Otolaryngology 6th edn. Butterworth Heinemann, Oxford, p 4/8/24Google Scholar
- 14.Merkus P, Ebbens FA, Muller B, Fokkens WJ (2006) The “best method” of topical nasal drug delivery: a comparison of seven techniques. Rhinology 44:102–110Google Scholar
- 16.Mygind N (1979) Conventional medical treatment. In: Nasal allergy, 2nd edn. Blackwell Scientific Publications, Oxford, pp257–270Google Scholar
- 17.Parkinson SN (1933) A lateral head-low position for nasal and sinus treatment. Arch Otolaryngol 17:787–788Google Scholar
- 19.Proetz AW (1926) Displacement irrigation of nasal sinuses. Arch Otolaryngol 4:1–13Google Scholar
- 20.Proetz AW (1927) Further data on the displacement method in sinuses. Ann Otol Rhinol Laryngol 36:297–323Google Scholar