Nasal septal perforation in a patient with subclinical celiac disease: a possible new association
Rhinology
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Abstract
A female patient presented with nasal septal perforation that did not respond to conventional therapeutic management. Later, because of a malabsorption problem in one of her children, she underwent analytic tests and distal duodenal biopsy, which revealed that she was suffering from subclinical/silent celiac disease. The treatment, a gluten-free diet, unexpectedly resulted in the cessation of the destructive nasal process. Four years later, the patient remains asymptomatic. Nasal septal perforation might constitute a new entity associated with celiac disease hitherto not described in the literature.
Keywords
Celiac disease Malabsorptive syndrome Septal nasal perforationReferences
- 1.Otley C, Hall RP (1990) Dermatitis herpetiformis. Dermatol Clin 8:759–769PubMedGoogle Scholar
- 2.Hall RP, Smith AD, Streilein RD (2000) Increased production of IL-4 by gut T-cell lines from patients with dermatitis herpetiformis compared to patients with isolated gluten-sensitive enteropathy. Dig Dis Sci 45:2036–2043CrossRefPubMedGoogle Scholar
- 3.Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GR (1999) The clinical pattern of subclinical/silent celiac disease: an analysis of 1,026 consecutive cases. Am J Gastroenterol 94:691–696PubMedGoogle Scholar
- 4.Tursi A, Giorgetti G, Brandimarte G, Rubino E, Lombardi D, Gasbarrini G (2001) Prevalence and clinical presentation of subclinical/silent celiac disease in adults: an analysis of a 12-year observation. Hepatogastroenterology 48:462–464PubMedGoogle Scholar
- 5.Kumar V, Rajadhyaksha M, Wortsman J (2001) Celiac disease-associated autoimmune endocrinopathies. Clin Diagn Lab Immunol 8:678–685CrossRefPubMedGoogle Scholar
- 6.Diamantopoulos II, Jones NS (2001) The investigation of nasal septal perforations and ulcers. J Laryngol Otol 115:541–544CrossRefPubMedGoogle Scholar
- 7.Thompson LD, Heffner DK (2001) Sinonasal tract eosinophilic angiocentric fibrosis. A report of three cases. Am J Clin Pathol 115:243–248CrossRefPubMedGoogle Scholar
- 8.Langford CA (2001) Wegener granulomatosis. Am J Med Sci 32:76–82CrossRefGoogle Scholar
- 9.Abbondanzo SL, Wenig BM (1995) Non-Hodgkin’s lymphoma of the sinonasal tract. A clinicopathologic and immunophenotypic study of 120 cases. Cancer 75:1281–1291PubMedGoogle Scholar
- 10.Davison SP, Habermann TM, Strickler JG, DeRemee RA, Earle JD, McDonald TJ (1996) Nasal and nasopharyngeal angiocentric T-cell lymphomas. Laryngoscope 106:139–143CrossRefPubMedGoogle Scholar
- 11.Smith I, Smith M, Mathias D, Wallis J (1996) Cryoglobulinaemia and septal perforation: a rare but logical cause. J Laryngol Otol 110:668–669PubMedGoogle Scholar
- 12.Baum ED, Boudousquie AC, Li S, Mirza N (1998) Sarcoidosis with nasal obstruction and septal perforation. Ear Nose Throat J 77:896–988, 900–902PubMedGoogle Scholar
- 13.Pardo-Mindan FJ, Lozano MD, Contreras-Mejuto F, de Alava E (1992) Pathology of heart transplant through endomyocardial biopsy. Semin Diagn Pathol 9:238–248PubMedGoogle Scholar
- 14.Lu CY, Sicher SC, Vázquez MA (1993) Prevention and treatment of renal allograft rejection: new therapeutic approaches and new insights into established therapies. J Am Soc Nephrol 4:1239–1256PubMedGoogle Scholar
- 15.Murray JA (1999) The widening spectrum of celiac disease. Am J Clin Nutr 69:354–365PubMedGoogle Scholar
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