Histological features and malignant transformation of inverted papilloma
Inverted papilloma (IP) is a primarily benign epithelial neoplasm with a propensity to transform to squamous cell carcinoma (SCC). Neither the etiology of IP nor the factors responsible for malignant transformation are fully known to date. A considerable number of histopathological grading systems have been suggested. It was the aim of this study to find histological parameters in IP that allow a prognosis concerning the occurrence of malignant transformation. In a group of 93 cases of IP, the patients’ records, histological specimens and a questionnaire were evaluated. Thirteen patients had suffered a recurrence of a previously treated IP. SCC in the IP had been diagnosed in 12 of the cases. The histological specimen showed increased counts of mitosis and dyscariosis in the IP. All other histological parameters did not show a significant difference between the groups. History and symptoms proved to be nonspecific as well. Patients in the group with SCC were significantly older at the first diagnosis of IP than patients without carcinoma. This group also included a higher portion of male patients. Patients fulfilling the named histological criteria combined with male gender and higher age are a high-risk group in the necessary long-term follow-up.
KeywordsInverterted papilloma Histology Neoplasm recurrence
- 3.Beck A, Kaiserling E, Rudert H, Beigel A (1984) Das Papilloma inversum der Nase und deren Nebenhöhlen. Laryngol Rhinol Otol 63:347–352Google Scholar
- 16.Jahnke V (1971) The fine structure of intranasal papillomas. Ann Otol 80:78–92Google Scholar
- 19.Kelly JH, Joseph M, Caroll E, Goodman ML, Pilch Z, Levinson RM, Strome M (1980) Inverted papilloma of the nasal septum. Otolaryngol 106:767–771Google Scholar
- 20.Kramer R, Som LM (1935) True papilloma of the nasal cavity. Arch Otolaryngol 22:22–43Google Scholar
- 28.Siivonen JA, Virolainen E (1989) Transitional papilloma of the nasal cavity and paranasal sinuses. Otol Rhinol Laryngol 51:262–267Google Scholar