Cytokine profile in paranasal effusions in patients with chronic sinusitis using the YAMIK sinus catheter with and without betamethasone

  • Kyosuke Furukido
  • Sachio Takeno
  • Tsutomu Ueda
  • Koji Yajin


Recently, the YAMIK sinus catheter (YAMIK) has been reported to be a useful therapeutic device in the treatment of sinusitis. The present study was conducted to compare its delivery of either a normal saline (NS) or a betamethasone solution (0.4 mg/ml) into the paranasal sinuses of 25 patients (39 sides) with chronic sinusitis. The following parameters were evaluated: (1) subjective nasal clinical symptoms (nasal discharge, nasal obstruction, postnasal drip and headache), (2) X-ray photographs (ethmoid and maxillary sinuses) and (3) cytokine levels (IL-1β, IL-8 and TNF-α) by enzyme-linked immunosorbent assay. The total nasal symptom scores significantly decreased after the first therapy, and the total X-ray photograph scores significantly decreased after therapy with either NS or the betamethasone solution. In both NS and betamethasone patients, the levels of IL-1β and IL-8 had significantly decreased by the 3rd and 2nd weeks after therapy, respectively. In contrast, the TNF-α level decreased after the first therapy with betamethasone solution and remained unchanged after therapy with NS. These findings suggest that evacuation of the pathological effusions in sinuses may exert a beneficial effect by reducing the levels of IL-1β and IL-8, and we speculate that removal of pathological effusions from the sinuses may provide treatment through different mechanisms than those that occur in treatment with betamethasone.


YAMIK sinus catheter Sinusitis Cytokine Betamethasone 



We thank Miss Keiko Nakagumi for the technical assistance. This study was supported by Grants-in-Aid for Scientific Research, administered by the Ministry of Education, Science, Sports and Culture, Japan (no. 13671781).


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Kyosuke Furukido
    • 1
  • Sachio Takeno
    • 1
  • Tsutomu Ueda
    • 1
  • Koji Yajin
    • 1
  1. 1.Department of OtorhinolaryngologyHiroshima University School of MedicineHiroshimaJapan

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