Etiopathogenesis of cholesteatoma

  • Ewa Olszewska
  • Mathias Wagner
  • Manuel Bernal-Sprekelsen
  • Jörg Ebmeyer
  • Stefan Dazert
  • Henning Hildmann
  • Holger Sudhoff


Cholesteatoma is a destructive lesion of the temporal bone that gradually expands and causes complications by erosion of the adjacent bony structures. Bone resorption can result in destruction of the ossicular chain and otic capsule with consecutive hearing loss, vestibular dysfunction, facial paralysis and intracranial complications. Surgery is the only treatment of choice. The etiopathogenesis of cholesteatoma, however, is still controversial. This review was designed to understand the reasons for these disparities and to reduce or eliminate them. Future studies focused on developmental, epidemiological, hormonal and genetic factors as well as on treatment are likely to contribute to further understanding of cholesteatoma pathogenesis.


Cholesteatoma Pathogenesis Growth factors Cytokines Bone destruction 


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Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Ewa Olszewska
    • 1
  • Mathias Wagner
    • 2
  • Manuel Bernal-Sprekelsen
    • 3
  • Jörg Ebmeyer
    • 4
  • Stefan Dazert
    • 5
  • Henning Hildmann
    • 5
  • Holger Sudhoff
    • 5
  1. 1.Department of Otorhinolaryngology and Head and Neck SurgeryMedical AcademyBialystokPoland
  2. 2.Department of General and Special PathologyRuhr University of BochumBochumGermany
  3. 3.Department of Otorhinolaryngology, Hospital ClinicUniversity of BarcelonaBarcelonaSpain
  4. 4.Department of Otorhinolaryngology and Head and Neck SurgeryUniversity of WürzburgWürzburgGermany
  5. 5.Department of Otorhinolaryngology and Head and Neck Surgery, St. Elisabeth HospitalUniversity of BochumBochumGermany

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