European Archives of Oto-Rhino-Laryngology

, Volume 260, Issue 6, pp 336–340 | Cite as

Paraganglioma of the nasal cavity: a case report

  • Sheyda Ketabchi
  • Daniela Massi
  • Roberto Santoro
  • Alessandro Franchi
Rhinology

Abstract

We describe the case of a 72-year-old woman presenting with a 1-year history of recurrent epistaxis and unilateral progressive nasal obstruction with associated rhinolalia resulting from the presence of a tumor mass occupying two-thirds of the right nasal cavity. Histopathologically, neoplastic cells or "chief cells" were arranged in well-defined nests, which had the classic alveolar or so-called "zellballen" pattern. Immunohistochemical studies highlighted the presence of S-100 protein-positive sustentacular cells located at the periphery of the clusters of chief cells. The chief cells showed a diffuse and intense positivity for neuron-specific enolase and synaptophysin. A diagnosis of paraganglioma was made. The lesion was excised completely and the patient did not develop recurrences or distant metastases after 8 months of follow-up. Paragangliomas arising in the nasal cavity and paranasal sinuses are extremely rare tumors. We report on the clinical, histopathological and immunohistochemical findings of our case and review the cases previously described in the literature.

Keywords

Paraganglioma Chemodectoma Nasal cavity Paranasal sinuses Immunohistochemistry. 

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  • Sheyda Ketabchi
    • 1
  • Daniela Massi
    • 1
  • Roberto Santoro
    • 2
  • Alessandro Franchi
    • 1
  1. 1.Dipartimento di Patologia Umana ed OncologiaUniversità degli Studi di FirenzeFirenzeItalia
  2. 2.Dipartimento di Scienze Chirurgiche Neuro-oto-oftalmologicheUniversità degli Studi di FirenzeFirenzeItalia

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