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The potential risk factors of placenta increta and the role of octamethylcyclotetrasiloxane

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Background

The study aimed to investigate the potential risk factors for the placenta accreta spectrum (PAS), determine the predictive value of a diagnostic model, and evaluate the effects of octamethylcyclotetrasiloxane (OMCTS) on trophoblast proliferation and migration.

Methods

This case–control study included 244 pregnant women with PAS and 327 normal pregnant women who visited Guangzhou Women and Children’s Medical Centre, China, from January 2014 to December 2017. Blood was collected from 42 women with PAS and 77 controls, and plasma specimens were analyzed by gas chromatography–time-of-flight mass spectrometry. In addition, the proliferation and migration of trophoblast cells were examined after treatment with OMCTS.

Results

We found an association between the risk of PAS and clinical factors related to fasting blood glucose levels (BS0, OR = 5.78), as well as factors related to endometrial injury [history of cesarean section (OR = 179.59), uterine scarring (OR = 68.37), and history of abortion (OR = 5.66)]. Equally important, pregnant women with PAS had significantly higher plasma OMCTS concentrations than controls. In vitro, we found that OMCTS could promote the proliferation and migration of HTR8/SVneo cells. The model of combining clinical factors and OMCTS had a good performance in PAS prediction (AUC = 0.97, 95% CI 0.78–0.93).

Conclusions

The early diagnosis of PAS in pregnant women requires assessing risk factors, metabolic status, and BS0 levels before 20 weeks of gestation. OMCTS may be related to the development of PAS by promoting trophoblast cell proliferation and migration.

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Data availability

All data generated or analyzed during this study are included in this published article.

Code availability

Not applicable.

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Acknowledgements

We thank the International Science Editing (http://www.internationalscienceediting.com) for editing this manuscript.

Funding

This work was supported by the National Natural Science Foundation of China (grant number: 81871716), the Natural Science Foundation of Guangdong Province (grant number: 2018A0303130314), and the Science and Technology Foundation of Guangzhou (grant numbers: 201704020109, 201707010019, and 201707010497). National Natural Science Foundation of China, 81871716, Hongling Yang, Natural Science Foundation of Guangdong Province, 2018A0303130314, Yan Long, Guizhou Science and Technology Department, 201704020109, Yan Long, 201707010019, Hongling Yang, 201707010497, Chunyan Zhu

Author information

Author notes

  1. Yan Long and Min Jiang contributed equally and should be considered as the co-first authors.

Authors and Affiliations

  1. Department of Laboratory, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, No. 9 Jinsui Road, Guangzhou, 510623, China

    Yan Long, Min Jiang, Fei Gao, Mengru Han, Shanshui Zeng, Yanwei Hu, Xianhui Dong & Hongling Yang

  2. School of Public Health, Guangzhou Medical University, Panyu District, Guangzhou, 511436, China

    Qiangsheng Gan, Weitao Ye & Chunyan Zhu

  3. Department of Gynecology and Obstetrics, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, Guangzhou, 510623, China

    Fangling Zeng

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  1. Yan Long
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Contributions

YL and HY conceived and directed the study; MJ, FG XD, and YL performed the analysis and visualization; MJ, MH, QG, FZ, SZ, and WY collected the samples; YL drafted the manuscript; and YH, HY, and CZ revised the manuscript.

Corresponding authors

Correspondence to Chunyan Zhu or Hongling Yang.

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Long, Y., Jiang, M., Gao, F. et al. The potential risk factors of placenta increta and the role of octamethylcyclotetrasiloxane. Arch Gynecol Obstet 306, 723–734 (2022). https://doi.org/10.1007/s00404-021-06335-w

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