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Ovarian reserve in patients with ankylosing spondylitis

  • General Gynecology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to determine the autoimmune effects of ankylosing spondylitis (AS) on the fertility potential of women by evaluating ovarian reserves of AS patients.

Methods

A total of 104 patients, 52 in the AS group (study group) and 52 in the control group were included in the study. Ovarian reserve was evaluated by serum anti-Müllerian hormone (AMH) levels, antral follicle count (AFC) and baseline serum follicle-stimulating hormone (FSH) levels.

Results

The mean serum AMH levels were significantly lower in the study group when compared to the controls (2.203 ± 1.110 vs. 1.188 ± 0.891, p < 0.001). In addition, the mean AFC was also significantly lower in the study group. (10.67 ± 1.81 vs. 9.54 ± 2.50, p = 0.009). Mean FSH levels were calculated to be 6.72 ± 1.14 in the study group and 7.21 ± 1.22 in the control group. The difference was not statistically significant (p = 0.781).

Conclusion

This study shows that AS like several other autoimmune conditions has an adverse effect on the female fertility potential. Therefore, an early start and long-term management of AS patients who have fertility desire is recommended. Serum AMH levels can be used in monitoring ovarian reserve and in early detection of reproductive decline of AS patients.

ClinicalTrial Number

NCT04209881.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Health Sciences University, 34000, Istanbul, Turkey

    Pınar Yalçın Bahat & Burak Yücel

  2. Department of Obstetrics and Gynecology, Acibadem University Atakent Hospital, Istanbul, Turkey

    Pınar Kadiroğulları

  3. Department of Obstetrics and Gynecology, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Health Sciences University, Istanbul, Turkey

    Nura Fitnat Topbas Selcuki

  4. Obstetrics and Gynecology, Esenler Maternity and Children’s Hospital, Istanbul, Turkey

    Kübra Çakmak

  5. Department of Obstetrics and Gynecology Ankara, Çubuk Halil Şıvgın Hospital, Çubuk, Turkey

    Eda Üreyen Özdemir

Authors
  1. Pınar Yalçın Bahat
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  2. Pınar Kadiroğulları
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  3. Nura Fitnat Topbas Selcuki
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  4. Burak Yücel
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  5. Kübra Çakmak
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  6. Eda Üreyen Özdemir
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Contributions

PYB: study designation and manuscript writing; PK: manuscript writing and statistical analysis; BY: data interpretation; EÜÖ: laboratory analysis; KÇ: statistical analysis; NFTS: critically revised the article and supervised the study.

Corresponding author

Correspondence to Pınar Yalçın Bahat.

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The authors have no conflict of interest to declare.

Ethics approval

The Institutional Review Board of Health Science University Istanbul Sadi Konuk Training and Research Hospital, Istanbul, Turkey approved this study (IRB Approval Number: 2019/456,).

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Informed consent was obtained from all individual participants included in the study.

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Yalçın Bahat, P., Kadiroğulları, P., Topbas Selcuki, N.F. et al. Ovarian reserve in patients with ankylosing spondylitis. Arch Gynecol Obstet 303, 189–193 (2021). https://doi.org/10.1007/s00404-020-05824-8

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  • DOI: https://doi.org/10.1007/s00404-020-05824-8

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